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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1978014524> ?p ?o ?g. }

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• W1978014524 startingPage "1778" @default.
• W1978014524 abstract "In this study, we investigated the effects of lentivirus (LV)-mediated short hairpin RNA (shRNA) targeting IGF-1R on the growth and lymphangiogenesis of breast cancer. The LV vector effectively delivered the IGF-1R shRNA to MDA-MB‑231 cells, leading to significant reduction of IGF-1R mRNA and protein expression. Infection of MDA-MB-231 cells with LV-IGF-1R shRNA reduced cell growth and migration. Transplantation of MDA-MB-231 cells with suppressed IGF-1R expression in SCID mice reduced tumor growth and lymphangiogenesis. These data collectively suggest that LV-mediated shRNA is an effective way to suppress IGF-1R expression and to inhibit growth and lymphangiogenesis of breast cancer. Specific inhibition of IGF-1R expression with shRNA represents a promising approach for the treatment of breast cancer." @default.
• W1978014524 created "2016-06-24" @default.
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• W1978014524 date "2012-08-10" @default.
• W1978014524 modified "2023-10-03" @default.
• W1978014524 title "Lentivirus-mediated short-hairpin RNA targeting IGF-1R inhibits growth and lymphangiogenesis in breast cancer" @default.
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• W1978014524 doi "https://doi.org/10.3892/or.2012.1964" @default.
• W1978014524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22895778" @default.
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