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• W1978582402 abstract "Heme is a proinflammatory molecule able to cause a profound delay of constitutive apoptosis of human neutrophils, an effect that likely contributes to chronic inflammation associated with hemolytic diseases. Herein we show that heme-induced delay of neutrophil apoptosis correlates with the prevention of mitochondrial potential (Δψm) dissipation by a mechanism dependent on NADPH oxidase (NADPHox)-generated reactive oxygen species (ROS) and NF-κB. Δψm maintenance is accompanied by inhibition of Bax insertion into mitochondria and by a decrease in the Bad/Bcl-XL ratio. Heme induces Bad degradation in a completely ROS-dependent manner, as well as Bcl-XL synthesis, a phenomenon that also requires NF-κB activation. These data indicate that heme-induced preservation of mitochondrial integrity is a critical checkpoint controlled by NADPH oxidase generated-ROS and redox-sensitive NF-κB activation." @default.
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• W1978582402 date "2006-11-01" @default.
• W1978582402 modified "2023-10-16" @default.
• W1978582402 title "NADPH oxidase-derived ROS: Key modulators of heme-induced mitochondrial stability in human neutrophils" @default.
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• W1978582402 doi "https://doi.org/10.1016/j.yexcr.2006.08.022" @default.
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