FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1985467097> ?p ?o ?g. }

• W1985467097 endingPage "570" @default.
• W1985467097 startingPage "564" @default.
• W1985467097 abstract "Objective: Deposition of the amyloid-β (Aβ) peptide in neuritic plaques is a requirement for the diagnosis of Alzheimer disease (AD). Although the continued development of in vivo imaging agents such as Pittsburgh compound B (PiB) is promising, the diagnosis of AD is still challenging. This can be partially attributed to our lack of a detailed understanding of the interrelationship between the various pools and species of Aβ and other common indices of AD pathology. We hypothesized that recent advances in our ability to accurately measure Aβ postmortem (for example, using PiB), could form the basis of a simple means to deliver an accurate AD diagnosis. Methods: We conducted a comprehensive analysis of the amount of Aβ40 and Aβ42 in increasingly insoluble fractions, oligomeric Aβ, and fibrillar Aβ (as defined by PiB binding), as well as plaques (diffuse and neuritic), and neurofibrillary tangles in autopsy specimens from age-matched, cognitively normal controls (n = 23) and AD (n = 22) cases, across multiple brain regions. Results: Both PiB binding and the amount of sodium dodecyl sulfate (SDS)-soluble Aβ were able to predict disease status; however, SDS-soluble Aβ was a better measure. Oligomeric Aβ was not a predictor of disease status. PiB binding was strongly related to plaque count, although diffuse plaques were a stronger correlate than neuritic plaques. Interpretation: Although postmortem PiB binding was somewhat useful in distinguishing AD from control cases, SDS-soluble Aβ measured by standard immunoassay was substantially better. These findings have important implications for the development of imaging-based biomarkers of AD. ANN NEUROL 2012;72:564–570" @default.
• W1985467097 created "2016-06-24" @default.
• W1985467097 creator A5007368132 @default.
• W1985467097 creator A5011049890 @default.
• W1985467097 creator A5044645853 @default.
• W1985467097 creator A5047600403 @default.
• W1985467097 creator A5049569922 @default.
• W1985467097 creator A5059075037 @default.
• W1985467097 creator A5062999763 @default.
• W1985467097 creator A5078885059 @default.
• W1985467097 creator A5081688346 @default.
• W1985467097 creator A5083504973 @default.
• W1985467097 date "2012-10-01" @default.
• W1985467097 modified "2023-09-27" @default.
• W1985467097 title "Pittsburgh compound B and the postmortem diagnosis of alzheimer disease" @default.
• W1985467097 cites W1539344686 @default.
• W1985467097 cites W1596429639 @default.
• W1985467097 cites W1605885548 @default.
• W1985467097 cites W1667268002 @default.
• W1985467097 cites W1835478781 @default.
• W1985467097 cites W1965870473 @default.
• W1985467097 cites W1967313796 @default.
• W1985467097 cites W1967823816 @default.
• W1985467097 cites W1980825524 @default.
• W1985467097 cites W1988370080 @default.
• W1985467097 cites W2005503435 @default.
• W1985467097 cites W2006219887 @default.
• W1985467097 cites W2017622907 @default.
• W1985467097 cites W2020008880 @default.
• W1985467097 cites W2020824841 @default.
• W1985467097 cites W2025563134 @default.
• W1985467097 cites W2036692413 @default.
• W1985467097 cites W2036741708 @default.
• W1985467097 cites W2038962904 @default.
• W1985467097 cites W2041668529 @default.
• W1985467097 cites W2052742260 @default.
• W1985467097 cites W2060683202 @default.
• W1985467097 cites W2068226389 @default.
• W1985467097 cites W2075481535 @default.
• W1985467097 cites W2076680453 @default.
• W1985467097 cites W2079536040 @default.
• W1985467097 cites W2086068246 @default.
• W1985467097 cites W2109727228 @default.
• W1985467097 cites W2114222094 @default.
• W1985467097 cites W2115077024 @default.
• W1985467097 cites W2125045513 @default.
• W1985467097 cites W2128228199 @default.
• W1985467097 cites W2136040838 @default.
• W1985467097 cites W2150999725 @default.
• W1985467097 cites W2156981442 @default.
• W1985467097 cites W2159122349 @default.
• W1985467097 cites W2166317402 @default.
• W1985467097 cites W2167720733 @default.
• W1985467097 cites W4247759744 @default.
• W1985467097 cites W4313105713 @default.
• W1985467097 doi "https://doi.org/10.1002/ana.23633" @default.
• W1985467097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3490445" @default.
• W1985467097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23109151" @default.
• W1985467097 hasPublicationYear "2012" @default.
• W1985467097 type Work @default.
• W1985467097 sameAs 1985467097 @default.
• W1985467097 citedByCount "31" @default.
• W1985467097 countsByYear W19854670972013 @default.
• W1985467097 countsByYear W19854670972014 @default.
• W1985467097 countsByYear W19854670972015 @default.
• W1985467097 countsByYear W19854670972016 @default.
• W1985467097 countsByYear W19854670972017 @default.
• W1985467097 countsByYear W19854670972018 @default.
• W1985467097 countsByYear W19854670972019 @default.
• W1985467097 countsByYear W19854670972020 @default.
• W1985467097 countsByYear W19854670972021 @default.
• W1985467097 crossrefType "journal-article" @default.
• W1985467097 hasAuthorship W1985467097A5007368132 @default.
• W1985467097 hasAuthorship W1985467097A5011049890 @default.
• W1985467097 hasAuthorship W1985467097A5044645853 @default.
• W1985467097 hasAuthorship W1985467097A5047600403 @default.
• W1985467097 hasAuthorship W1985467097A5049569922 @default.
• W1985467097 hasAuthorship W1985467097A5059075037 @default.
• W1985467097 hasAuthorship W1985467097A5062999763 @default.
• W1985467097 hasAuthorship W1985467097A5078885059 @default.
• W1985467097 hasAuthorship W1985467097A5081688346 @default.
• W1985467097 hasAuthorship W1985467097A5083504973 @default.
• W1985467097 hasBestOaLocation W19854670972 @default.
• W1985467097 hasConcept C142724271 @default.
• W1985467097 hasConcept C2777633098 @default.
• W1985467097 hasConcept C2779134260 @default.
• W1985467097 hasConcept C2779504383 @default.
• W1985467097 hasConcept C2781073650 @default.
• W1985467097 hasConcept C502032728 @default.
• W1985467097 hasConcept C68026918 @default.
• W1985467097 hasConcept C70097482 @default.
• W1985467097 hasConcept C71924100 @default.
• W1985467097 hasConceptScore W1985467097C142724271 @default.
• W1985467097 hasConceptScore W1985467097C2777633098 @default.
• W1985467097 hasConceptScore W1985467097C2779134260 @default.
• W1985467097 hasConceptScore W1985467097C2779504383 @default.
• W1985467097 hasConceptScore W1985467097C2781073650 @default.
• W1985467097 hasConceptScore W1985467097C502032728 @default.

• next