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• W1985643334 endingPage "2634" @default.
• W1985643334 startingPage "2627" @default.
• W1985643334 abstract "The thermodynamic stability of nine dodecamers (four DNA and five RNA) of the same base composition has been compared by UV-melting. The ΔG of stabilisation were in the order: r(GACUGAUCAGUC) 2 > r(CGCAAATTTGCG) 2 ≈ r(CGCAUAUAUGCG) 2 > d(CGCAAATTTGCG) 2 ≈ r(CGCAAAUUUGCG) 2 > d(CGCATATATGCG) 2 ≈ d(GACTGATCAGTC) 2 > r(CGCUUUAAAGCG) 2 ≈ d(CGCTTTAAAGCG) 2 . Compared with the mixed sequences, both r(AAAUUU) and r(UUUAAA) are greatly destablising in RNA, whereas in DNA, d(TTTAAA) is destabilising but d(AAATTT) is stabilising, which has been attributed to the formation of a special B′ structure involving large propeller twists of the A-T base pairs. The solution structure of the RNA dodecamer r(CGCAAAUUUGCG) 2 has been determined using NMR and restrained molecular dynamics calculations to assess the conformational reasons for its stability in comparison with d(CGCAAATTTGCG) 2 . The structures refined to a mean pairwise r.m.s.d. of 0.89 ± 0.29 Å. The nucleotide conformations are typical of the A family of structures. However, although the helix axis displacement is ∼4.6 Å into the major groove, the rise (3.0 Å) and base inclination (∼6°) are different from standard A form RNA. The extensive base-stacking found in the AAATTT tract of the DNA homologue that is largely responsible for the higher thermodynamic stability of the DNA duplex is reduced in the RNA structure, which may account for its low relative stability." @default.
• W1985643334 created "2016-06-24" @default.
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• W1985643334 date "1997-07-01" @default.
• W1985643334 modified "2023-09-25" @default.
• W1985643334 title "Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2" @default.
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• W1985643334 doi "https://doi.org/10.1093/nar/25.13.2627" @default.
• W1985643334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/146795" @default.
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• W1985643334 hasPublicationYear "1997" @default.
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