FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1986070812> ?p ?o ?g. }

• W1986070812 endingPage "e110833" @default.
• W1986070812 startingPage "e110833" @default.
• W1986070812 abstract "Slick (Slo2.1) and Slack (Slo2.2) channels belong to the family of high-conductance K+ channels and have been found widely distributed in the CNS. Both channels are activated by Na+ and Cl− and, in addition, Slick channels are regulated by ATP. Therefore, the roles of these channels in regulation of cell excitability as well as ion transport processes, like regulation of cell volume, have been hypothesized. It is the aim of this work to evaluate the sensitivity of Slick and Slack channels to small, fast changes in cell volume and to explore mechanisms, which may explain this type of regulation. For this purpose Slick and Slack channels were co-expressed with aquaporin 1 in Xenopus laevis oocytes and cell volume changes of around 5% were induced by exposure to hypotonic or hypertonic media. Whole-cell currents were measured by two electrode voltage clamp. Our results show that Slick channels are dramatically stimulated (196% of control) by cell swelling and inhibited (57% of control) by a decrease in cell volume. In contrast, Slack channels are totally insensitive to similar cell volume changes. The mechanism underlining the strong volume sensitivity of Slick channels needs to be further explored, however we were able to show that it does not depend on an intact actin cytoskeleton, ATP release or vesicle fusion. In conclusion, Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume." @default.
• W1986070812 created "2016-06-24" @default.
• W1986070812 creator A5027791484 @default.
• W1986070812 creator A5044038822 @default.
• W1986070812 creator A5052906959 @default.
• W1986070812 creator A5067510654 @default.
• W1986070812 creator A5074300840 @default.
• W1986070812 creator A5086534242 @default.
• W1986070812 date "2014-10-27" @default.
• W1986070812 modified "2023-10-16" @default.
• W1986070812 title "Cell Volume Changes Regulate Slick (Slo2.1), but Not Slack (Slo2.2) K+ Channels" @default.
• W1986070812 cites W1556161696 @default.
• W1986070812 cites W1970103114 @default.
• W1986070812 cites W1973333921 @default.
• W1986070812 cites W1984991691 @default.
• W1986070812 cites W1985276481 @default.
• W1986070812 cites W1987778629 @default.
• W1986070812 cites W2011920501 @default.
• W1986070812 cites W2013281087 @default.
• W1986070812 cites W2036163830 @default.
• W1986070812 cites W2039606438 @default.
• W1986070812 cites W2043525076 @default.
• W1986070812 cites W2043630980 @default.
• W1986070812 cites W2046992902 @default.
• W1986070812 cites W2054605499 @default.
• W1986070812 cites W2055716703 @default.
• W1986070812 cites W2063307605 @default.
• W1986070812 cites W2077682224 @default.
• W1986070812 cites W2078403542 @default.
• W1986070812 cites W2085940790 @default.
• W1986070812 cites W2093284652 @default.
• W1986070812 cites W2099865289 @default.
• W1986070812 cites W2111469368 @default.
• W1986070812 cites W2112818865 @default.
• W1986070812 cites W2124139677 @default.
• W1986070812 cites W2125278201 @default.
• W1986070812 cites W2125588561 @default.
• W1986070812 cites W2126699241 @default.
• W1986070812 cites W2129889192 @default.
• W1986070812 cites W2131492802 @default.
• W1986070812 cites W2155460061 @default.
• W1986070812 cites W2157033897 @default.
• W1986070812 cites W2171553829 @default.
• W1986070812 cites W2172011313 @default.
• W1986070812 doi "https://doi.org/10.1371/journal.pone.0110833" @default.
• W1986070812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4210196" @default.
• W1986070812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25347289" @default.
• W1986070812 hasPublicationYear "2014" @default.
• W1986070812 type Work @default.
• W1986070812 sameAs 1986070812 @default.
• W1986070812 citedByCount "18" @default.
• W1986070812 countsByYear W19860708122015 @default.
• W1986070812 countsByYear W19860708122016 @default.
• W1986070812 countsByYear W19860708122017 @default.
• W1986070812 countsByYear W19860708122018 @default.
• W1986070812 countsByYear W19860708122020 @default.
• W1986070812 countsByYear W19860708122023 @default.
• W1986070812 crossrefType "journal-article" @default.
• W1986070812 hasAuthorship W1986070812A5027791484 @default.
• W1986070812 hasAuthorship W1986070812A5044038822 @default.
• W1986070812 hasAuthorship W1986070812A5052906959 @default.
• W1986070812 hasAuthorship W1986070812A5067510654 @default.
• W1986070812 hasAuthorship W1986070812A5074300840 @default.
• W1986070812 hasAuthorship W1986070812A5086534242 @default.
• W1986070812 hasBestOaLocation W19860708121 @default.
• W1986070812 hasConcept C104317684 @default.
• W1986070812 hasConcept C12554922 @default.
• W1986070812 hasConcept C147944092 @default.
• W1986070812 hasConcept C169760540 @default.
• W1986070812 hasConcept C185263204 @default.
• W1986070812 hasConcept C185592680 @default.
• W1986070812 hasConcept C2779535977 @default.
• W1986070812 hasConcept C55493867 @default.
• W1986070812 hasConcept C86803240 @default.
• W1986070812 hasConcept C95444343 @default.
• W1986070812 hasConceptScore W1986070812C104317684 @default.
• W1986070812 hasConceptScore W1986070812C12554922 @default.
• W1986070812 hasConceptScore W1986070812C147944092 @default.
• W1986070812 hasConceptScore W1986070812C169760540 @default.
• W1986070812 hasConceptScore W1986070812C185263204 @default.
• W1986070812 hasConceptScore W1986070812C185592680 @default.
• W1986070812 hasConceptScore W1986070812C2779535977 @default.
• W1986070812 hasConceptScore W1986070812C55493867 @default.
• W1986070812 hasConceptScore W1986070812C86803240 @default.
• W1986070812 hasConceptScore W1986070812C95444343 @default.
• W1986070812 hasIssue "10" @default.
• W1986070812 hasLocation W19860708121 @default.
• W1986070812 hasLocation W19860708122 @default.
• W1986070812 hasLocation W19860708123 @default.
• W1986070812 hasLocation W19860708124 @default.
• W1986070812 hasLocation W19860708125 @default.
• W1986070812 hasLocation W19860708126 @default.
• W1986070812 hasOpenAccess W1986070812 @default.
• W1986070812 hasPrimaryLocation W19860708121 @default.
• W1986070812 hasRelatedWork W1967827908 @default.
• W1986070812 hasRelatedWork W2018691473 @default.
• W1986070812 hasRelatedWork W2045286669 @default.
• W1986070812 hasRelatedWork W2080931623 @default.

• next