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• W1990052105 abstract "Picornaviruses are important human pathogens causing severe morbidity and some mortality with the potential to cause worldwide crippling disease. Currently, there are few treatments for many of the viruses in the Picornaviridae, For rhinoviruses, there are no approved treatments, although ruprintrivir looks promising in clinical trials and pyridazinyl oxime ethers may prove useful. Poliovirus treatments are needed to supplement the World Health Organizations polio eradication plan in order to treat infections caused by reversion of the attenuated vaccine virus and to supplement vaccine coverage control in polio endemic areas. However, no promising compounds for treatment of poliovirus have been developed due to the efficacy of the vaccines in use. Broad-spectrum inhibitors developed for other picornavirus may be useful for poliovirus infections. Coxsackievirus infections in children and in infants are being treated with pleconaril with some efficacy in reducing mortality and improving recovery, albeit the treatment is often on a compassionate use basis. There are no therapies for echovirus infections. Very little drug discovery research is being done to develop inhibitors for echovirus infections, probably due to the broad-spectrum inhibition exhibited by capsid binding agents and protease inhibitors discovered for treatment of other picornaviruses. For example, pyridazinyl oxime ethers are inhibitory to most echoviruses. Treatments for enterovirus infections are also limited, although in a small clinical trial, milrinone seemed to reduce mortality and improve recovery from EV71-induced pulmonary edema. Thus, these results strongly emphasize the need for the development of potent and nontoxic compounds for the treatment of picornavirus infections. Keywords: therapy, antiviral, enterovirus, poliovirus, coxsackievirus, echovirus, rhinovirus, Picornavirus" @default.
• W1990052105 created "2016-06-24" @default.
• W1990052105 creator A5068456155 @default.
• W1990052105 date "2006-04-01" @default.
• W1990052105 modified "2023-10-15" @default.
• W1990052105 title "Current Status of Anti-Picornavirus Therapies" @default.
• W1990052105 cites W134962746 @default.
• W1990052105 cites W1499721021 @default.
• W1990052105 cites W1516024715 @default.
• W1990052105 cites W1864601388 @default.
• W1990052105 cites W1953661334 @default.
• W1990052105 cites W1968966900 @default.
• W1990052105 cites W1969332353 @default.
• W1990052105 cites W1969568408 @default.
• W1990052105 cites W1970511970 @default.
• W1990052105 cites W1970750462 @default.
• W1990052105 cites W1971454261 @default.
• W1990052105 cites W1974173496 @default.
• W1990052105 cites W1974325677 @default.
• W1990052105 cites W1977164495 @default.
• W1990052105 cites W1982980945 @default.
• W1990052105 cites W1983664771 @default.
• W1990052105 cites W1984643489 @default.
• W1990052105 cites W1991375283 @default.
• W1990052105 cites W1994780435 @default.
• W1990052105 cites W1999996222 @default.
• W1990052105 cites W2009914756 @default.
• W1990052105 cites W2017221885 @default.
• W1990052105 cites W2019032733 @default.
• W1990052105 cites W2022838977 @default.
• W1990052105 cites W2025551423 @default.
• W1990052105 cites W2025884598 @default.
• W1990052105 cites W2027806414 @default.
• W1990052105 cites W2028220671 @default.
• W1990052105 cites W2034039261 @default.
• W1990052105 cites W2034084380 @default.
• W1990052105 cites W2037140037 @default.
• W1990052105 cites W2037293944 @default.
• W1990052105 cites W2042047984 @default.
• W1990052105 cites W2046833643 @default.
• W1990052105 cites W2047435366 @default.
• W1990052105 cites W2048860817 @default.
• W1990052105 cites W2049854052 @default.
• W1990052105 cites W2053007639 @default.
• W1990052105 cites W2053250098 @default.
• W1990052105 cites W2060830729 @default.
• W1990052105 cites W2065366950 @default.
• W1990052105 cites W2068119827 @default.
• W1990052105 cites W2068520092 @default.
• W1990052105 cites W2068751000 @default.
• W1990052105 cites W2068797155 @default.
• W1990052105 cites W2070218296 @default.
• W1990052105 cites W2074490457 @default.
• W1990052105 cites W2074507404 @default.
• W1990052105 cites W2075945005 @default.
• W1990052105 cites W2080816934 @default.
• W1990052105 cites W2086250592 @default.
• W1990052105 cites W2088439570 @default.
• W1990052105 cites W2093221020 @default.
• W1990052105 cites W2093714535 @default.
• W1990052105 cites W2098388207 @default.
• W1990052105 cites W2108528458 @default.
• W1990052105 cites W2112087122 @default.
• W1990052105 cites W2114626540 @default.
• W1990052105 cites W2114756811 @default.
• W1990052105 cites W2115289014 @default.
• W1990052105 cites W2115769763 @default.
• W1990052105 cites W2124026826 @default.
• W1990052105 cites W2127062009 @default.
• W1990052105 cites W2130612498 @default.
• W1990052105 cites W2132798753 @default.
• W1990052105 cites W2136285280 @default.
• W1990052105 cites W2137037618 @default.
• W1990052105 cites W2137457701 @default.
• W1990052105 cites W2144180956 @default.
• W1990052105 cites W2144529619 @default.
• W1990052105 cites W2148814589 @default.
• W1990052105 cites W2150247325 @default.
• W1990052105 cites W2160298781 @default.
• W1990052105 cites W2161275880 @default.
• W1990052105 cites W2165413957 @default.
• W1990052105 cites W2169357494 @default.
• W1990052105 cites W2170813038 @default.
• W1990052105 cites W2171819561 @default.
• W1990052105 cites W2177215675 @default.
• W1990052105 cites W2314786623 @default.
• W1990052105 cites W2315624236 @default.
• W1990052105 cites W2327595839 @default.
• W1990052105 cites W2337133922 @default.
• W1990052105 cites W2348074755 @default.
• W1990052105 cites W2358167702 @default.
• W1990052105 cites W2365321912 @default.
• W1990052105 cites W2385129284 @default.
• W1990052105 cites W2405366220 @default.
• W1990052105 cites W2406214918 @default.
• W1990052105 cites W2414064449 @default.
• W1990052105 cites W2418545473 @default.
• W1990052105 cites W2428074373 @default.

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