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• W1991254229 abstract "Neural retina development results from growth arrest of neuroectodermal precursors and differentiation of postmitotic cells. The QRI gene is specifically expressed in Müller retinal glial cells. Its expression coincides with the stage of withdrawal from the cell cycle and establishment of differentiation and is repressed upon induction of retinal cell proliferation by the v-src gene product. In this report, we show that the QR1 gene encodes several glycosylated proteins that are secreted and can either associate with the extracellular matrix or remain diffusible in the medium. By using pulse-chase experiments, the 100-103 kDa forms seem to appear first and are specifically incorporated into the extracellular matrix, whereas the 108 and 60 kDa polypeptides appear later and are detected as soluble forms in the culture medium. We also report that expression of the QR1 gene is developmentally regulated in the chicken. Its mRNA is first detectable at embryonic day 10, reaches a maximal level at embryonic day 15 and is no longer detected at embryonic day 18. Immunolocalization of the QR1 protein in chicken retina sections during development shows that expression of the protein parallels the differentiation pattern of post-miotic cells (in particular Müller cells and rods), corresponding to the two differentiation gradients in the retina: from the ganglion cell layer to the inner nuclear layer and outer nuclear layer, and from the optic nerve to the iris. At embryonic day 10, expression of the QR1 protein(s) is restricted to the optic nerve region and the inner nuclear layer, colocalizing with Müller cell bodies. As development proceeds, QR1 protein localization spreads towards the iris and towards the outer nuclear layer, following Müller cell elongations towards the photoreceptors. Between embryonic days 16 and 18, the QR1 protein is no longer detectable in the optic nerve region and is concentrated around the basal segment of the photoreceptors in the peripheral retina. Our results suggest a role for the QR1 gene product in the process of growth arrest and establishment of photoreceptor differentiation." @default.
• W1991254229 created "2016-06-24" @default.
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• W1991254229 date "1996-02-01" @default.
• W1991254229 modified "2023-09-30" @default.
• W1991254229 title "QR1, a retina-specific gene, encodes an extracellular matrix protein exclusively expressed during neural retina differentiation" @default.
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• W1991254229 cites W1776293250 @default.
• W1991254229 cites W1821151201 @default.
• W1991254229 cites W1824239451 @default.
• W1991254229 cites W1963979467 @default.
• W1991254229 cites W1968911057 @default.
• W1991254229 cites W1969019995 @default.
• W1991254229 cites W1969809933 @default.
• W1991254229 cites W1970928680 @default.
• W1991254229 cites W1973524445 @default.
• W1991254229 cites W1981191996 @default.
• W1991254229 cites W1984841015 @default.
• W1991254229 cites W1984976681 @default.
• W1991254229 cites W1985673701 @default.
• W1991254229 cites W1988169283 @default.
• W1991254229 cites W1989765568 @default.
• W1991254229 cites W1990905632 @default.
• W1991254229 cites W1996010797 @default.
• W1991254229 cites W2003937770 @default.
• W1991254229 cites W2006577331 @default.
• W1991254229 cites W2007548014 @default.
• W1991254229 cites W2009366281 @default.
• W1991254229 cites W2009385541 @default.
• W1991254229 cites W2013968703 @default.
• W1991254229 cites W2014913262 @default.
• W1991254229 cites W2016546102 @default.
• W1991254229 cites W2018938193 @default.
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• W1991254229 cites W2026274081 @default.
• W1991254229 cites W2027204848 @default.
• W1991254229 cites W2029524468 @default.
• W1991254229 cites W2031468048 @default.
• W1991254229 cites W2031596923 @default.
• W1991254229 cites W2034577585 @default.
• W1991254229 cites W2040585227 @default.
• W1991254229 cites W2041362832 @default.
• W1991254229 cites W2041520211 @default.
• W1991254229 cites W2044787075 @default.
• W1991254229 cites W2050826503 @default.
• W1991254229 cites W2052733021 @default.
• W1991254229 cites W2054887464 @default.
• W1991254229 cites W2060333628 @default.
• W1991254229 cites W2061829345 @default.
• W1991254229 cites W2062211424 @default.
• W1991254229 cites W2064540868 @default.
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• W1991254229 cites W2087444540 @default.
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• W1991254229 cites W2116607514 @default.
• W1991254229 cites W2121038777 @default.
• W1991254229 cites W2127186381 @default.
• W1991254229 cites W2133607143 @default.
• W1991254229 cites W2138559670 @default.
• W1991254229 cites W2152761671 @default.
• W1991254229 cites W2155222159 @default.
• W1991254229 cites W2155921150 @default.
• W1991254229 cites W2200030141 @default.
• W1991254229 cites W2338171046 @default.
• W1991254229 cites W2404698253 @default.
• W1991254229 cites W4249117825 @default.
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• W1991254229 doi "https://doi.org/10.1016/0925-4773(95)00482-3" @default.
• W1991254229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8652416" @default.
• W1991254229 hasPublicationYear "1996" @default.
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