Matches in SemOpenAlex for { <https://semopenalex.org/work/W1991498850> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1991498850 endingPage "570" @default.
- W1991498850 startingPage "564" @default.
- W1991498850 abstract "Overexpression of the growth factor receptor ErbB-2/Her2/Neu has been implicated in the development of non-small-cell lung cancer. We have reported that the transformation of human lung epithelial cells by c-erbB-2 also requires an active ErbB-1 (EGF receptor) and the autocrine production of its ligand, TGF-alpha. In this report, we demonstrate that STAT 3 is constitutively activated in these cells by the TGF-alpha-stimulated ErbB-1/-2 heterodimer complex. STAT 3 activation was confirmed by mobility shift assays and nuclear localization. ErbB-1 was required, but not sufficient for the TGF-alpha-induced activation of STATs. Inhibition of ErbB-2 kinase activity by tyrphostin AG825 prevented the constitutive activation of STAT 3 in the TGF-alpha-producing, ErbB-1 expressing cell line. Our results demonstrate a requirement for ErbB-2 kinase activity to establish constitutive STAT 3 activation resulting from an autocrine ErbB-1/ TGF-alpha loop. Int. J. Cancer 83:564-570, 1999. Published 1999 Wiley-Liss, Inc." @default.
- W1991498850 created "2016-06-24" @default.
- W1991498850 creator A5058620859 @default.
- W1991498850 creator A5069049193 @default.
- W1991498850 creator A5088554919 @default.
- W1991498850 date "1999-11-12" @default.
- W1991498850 modified "2023-10-13" @default.
- W1991498850 title "ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells" @default.
- W1991498850 cites W1544215724 @default.
- W1991498850 cites W1553277501 @default.
- W1991498850 cites W1601571585 @default.
- W1991498850 cites W1644491781 @default.
- W1991498850 cites W1933735120 @default.
- W1991498850 cites W1969405162 @default.
- W1991498850 cites W1984486504 @default.
- W1991498850 cites W2012375478 @default.
- W1991498850 cites W2016730049 @default.
- W1991498850 cites W2027286533 @default.
- W1991498850 cites W2028662905 @default.
- W1991498850 cites W2042169992 @default.
- W1991498850 cites W2044365382 @default.
- W1991498850 cites W2044991100 @default.
- W1991498850 cites W2054070431 @default.
- W1991498850 cites W2058839845 @default.
- W1991498850 cites W2068724210 @default.
- W1991498850 cites W2095156669 @default.
- W1991498850 cites W2107631090 @default.
- W1991498850 cites W2111941775 @default.
- W1991498850 cites W2163046152 @default.
- W1991498850 cites W2168402832 @default.
- W1991498850 doi "https://doi.org/10.1002/(sici)1097-0215(19991112)83:4<564::aid-ijc20>3.0.co;2-q" @default.
- W1991498850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10508495" @default.
- W1991498850 hasPublicationYear "1999" @default.
- W1991498850 type Work @default.
- W1991498850 sameAs 1991498850 @default.
- W1991498850 citedByCount "119" @default.
- W1991498850 countsByYear W19914988502012 @default.
- W1991498850 countsByYear W19914988502013 @default.
- W1991498850 countsByYear W19914988502014 @default.
- W1991498850 countsByYear W19914988502015 @default.
- W1991498850 countsByYear W19914988502017 @default.
- W1991498850 countsByYear W19914988502021 @default.
- W1991498850 crossrefType "journal-article" @default.
- W1991498850 hasAuthorship W1991498850A5058620859 @default.
- W1991498850 hasAuthorship W1991498850A5069049193 @default.
- W1991498850 hasAuthorship W1991498850A5088554919 @default.
- W1991498850 hasBestOaLocation W19914988501 @default.
- W1991498850 hasConcept C118131993 @default.
- W1991498850 hasConcept C125555471 @default.
- W1991498850 hasConcept C128240485 @default.
- W1991498850 hasConcept C134018914 @default.
- W1991498850 hasConcept C170493617 @default.
- W1991498850 hasConcept C2779251935 @default.
- W1991498850 hasConcept C2779438470 @default.
- W1991498850 hasConcept C502942594 @default.
- W1991498850 hasConcept C55493867 @default.
- W1991498850 hasConcept C62478195 @default.
- W1991498850 hasConcept C86803240 @default.
- W1991498850 hasConcept C95444343 @default.
- W1991498850 hasConceptScore W1991498850C118131993 @default.
- W1991498850 hasConceptScore W1991498850C125555471 @default.
- W1991498850 hasConceptScore W1991498850C128240485 @default.
- W1991498850 hasConceptScore W1991498850C134018914 @default.
- W1991498850 hasConceptScore W1991498850C170493617 @default.
- W1991498850 hasConceptScore W1991498850C2779251935 @default.
- W1991498850 hasConceptScore W1991498850C2779438470 @default.
- W1991498850 hasConceptScore W1991498850C502942594 @default.
- W1991498850 hasConceptScore W1991498850C55493867 @default.
- W1991498850 hasConceptScore W1991498850C62478195 @default.
- W1991498850 hasConceptScore W1991498850C86803240 @default.
- W1991498850 hasConceptScore W1991498850C95444343 @default.
- W1991498850 hasIssue "4" @default.
- W1991498850 hasLocation W19914988501 @default.
- W1991498850 hasLocation W19914988502 @default.
- W1991498850 hasOpenAccess W1991498850 @default.
- W1991498850 hasPrimaryLocation W19914988501 @default.
- W1991498850 hasRelatedWork W1975953165 @default.
- W1991498850 hasRelatedWork W1983875848 @default.
- W1991498850 hasRelatedWork W2009918227 @default.
- W1991498850 hasRelatedWork W2049319935 @default.
- W1991498850 hasRelatedWork W2093005427 @default.
- W1991498850 hasRelatedWork W2315534698 @default.
- W1991498850 hasRelatedWork W2406828156 @default.
- W1991498850 hasRelatedWork W2407862349 @default.
- W1991498850 hasRelatedWork W2465947594 @default.
- W1991498850 hasRelatedWork W302886876 @default.
- W1991498850 hasVolume "83" @default.
- W1991498850 isParatext "false" @default.
- W1991498850 isRetracted "false" @default.
- W1991498850 magId "1991498850" @default.
- W1991498850 workType "article" @default.