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- W1992287572 abstract "s / Pancreatology 14 (2014) S1eS129 S57 pancreatitis was induced by four hourly injections of caerulein [50 mg/kg/ dose] and in the high dose group by8 injections. Further, one groupof animals that received 4 injections was given a longer duration of injury by sacrificing this group at the 9th hour after the induction of pancreatitis by caerulein. The pancreatic tissue was processed for transmission electron microscopy. Results: The acinar cells of the pancreatitis groups revealed autophagosomes that contained cellular organelles, including mitochondria. The animals that received a higher dose had numerous cells showing a necrotic morphology, whereas the animals in the low dose group showed a predominantly apoptotic cell morphology. Conclusion: Dysfunctional organelles in the injured pancreatic acinar cells are degraded by macroautophagy that includes mitochondriae. The consequent energy deficit in the cells may lead to necrosis." @default.
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- W1992287572 date "2014-06-01" @default.
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- W1992287572 title "Association of carboxyl-ester lipase variable nucleotide tandem repeat with alcoholic chronic pancreatitis and alcoholic liver disease" @default.
- W1992287572 doi "https://doi.org/10.1016/j.pan.2014.05.573" @default.
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