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• W1993467159 abstract "<h3>Objective</h3>To increase the recognition of glutamic acid decarboxylase autoantibodies–related encephalitis in childhood.<h3>Design</h3>Case report and review of the literature.<h3>Patient</h3>A 6-year-old girl who had developed refractory seizures, developmental regression, and type 1 diabetes mellitus at age 25 months.<h3>Interventions</h3>Blood analysis, electroencephalogram, cerebral magnetic resonance imaging, positron emission tomography scan, lumbar puncture, and measurement of glutamic acid decarboxylase activity were performed. Treatment with repeated plasmapheresis and rituximab, with concomitant antiepileptic drugs, was administered.<h3>Results</h3>Highly elevated titers of glutamic acid decarboxylase autoantibodies were found in the serum, as well as in the cerebrospinal fluid. Major clinical improvement in parallel with a decrease in the levels of serum and cerebrospinal fluid antibodies was observed with treatment.<h3>Conclusions</h3>Encephalitis associated with glutamic acid decarboxylase autoantibodies is a severe epileptic disorder that occurs in young children as well as adults. It may be partially reversible with aggressive immunomodulatory treatment, including plasmapheresis and rituximab. Studies are warranted to determine whether early treatment leads to complete remission." @default.
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• W1993467159 date "2011-08-01" @default.
• W1993467159 modified "2023-09-23" @default.
• W1993467159 title "Encephalitis Associated With Glutamic Acid Decarboxylase Autoantibodies in a Child" @default.
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• W1993467159 doi "https://doi.org/10.1001/archneurol.2011.177" @default.
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