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• W1993896262 abstract "ABSTRACT Bacillus subtilis produces an anionic bacteriocin called subtilosin A that possesses antibacterial activity against certain gram-positive bacteria. In this study, we uncovered a hemolytic mutant of B. subtilis that produces an altered form of subtilosin A. The mutant bacteriocin, named subtilosin A1, has a replacement of threonine at position 6 with isoleucine. In addition to the hemolytic activity, subtilosin A1 was found to exhibit enhanced antimicrobial activity against specific bacterial strains. The B. subtilis albB mutant that does not produce a putative immunity peptide was more sensitive to both subtilosin A and subtilosin A1. A spontaneous suppressor mutation of albB that restored resistance to subtilosin A and subtilosin A1 was obtained. The sbr ( s u b tilosin r esistance) mutation conferring the resistance is not linked to the sboA-alb locus. The sbr mutation does not increase the resistance of B. subtilis to other cell envelope-targeted antimicrobial agents, indicating that the mutation specifically confers the resistance to subtilosins. The findings suggest possible bioengineering approaches for obtaining anionic bacteriocins with enhanced and/or altered bactericidal activity. Furthermore, future identification of the subtilosin-resistant mutation could provide insights into the mechanism of subtilosin A activity." @default.
• W1993896262 created "2016-06-24" @default.
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• W1993896262 date "2009-09-15" @default.
• W1993896262 modified "2023-09-23" @default.
• W1993896262 title "Isolation of a Variant of Subtilosin A with Hemolytic Activity" @default.
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• W1993896262 doi "https://doi.org/10.1128/jb.00541-09" @default.
• W1993896262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2737964" @default.
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