FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994029062> ?p ?o ?g. }

• W1994029062 endingPage "14" @default.
• W1994029062 startingPage "8" @default.
• W1994029062 abstract "Blood thyroid function tests (TFT) are routinely used to screen for thyroid disorders in several clinical settings. TFT on hospital admission may also be useful prognostic predictors of acute IS: according to recent evidence, poststroke outcome is better in patients with lower thyroid function and worse in those with higher thyroid function. However, previous reports are few and mostly compared patients with thyroid disorders to euthyroid patients. Thyroid disorders are known risk factors for cerebrovascular disease. However, hyperthyroidism is related to cardioembolic IS whereas hypothyroidism is related to atherosclerotic risk factors. Therefore, findings from available studies of TFT might just reflect the worse prognosis of cardioembolic IS compared to other IS subtypes. Another limitation of previous studies is the lack of information for older persons, who represent three quarters of all IS patients. In this paper, we investigated whether serum thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) measured on Stroke Unit (SU) admission are associated with early outcomes of acute IS in 775 euthyroid patients aged ≥ 65 years (mean age 80.1 ± 8.7 years). Two composite outcomes were investigated: poor functional outcome (death during SU stay or disability at SU discharge), and unfavorable discharge setting (death during SU stay, transfer from SU to other acute hospital unit or transfer from SU to long-term care-facilities as opposed to direct discharge home). Analyses were performed using logistic regression models. Curvilinear associations were tested including TFT as polynomial terms. Models were adjusted for demographics, prestroke, and IS-related confounders. We found that lower TSH had a complex curvilinear association with poor functional outcome and that the shape of the associations changed with age. At age 65, the curve was U-shaped: outcome risk decreased with increasing TSH, reached its minimum at TSH near 3.00 mUI/L and then started to rise. Between ages 70 and 75, however, the shape of the curve straightened and, starting from age 80 took an inverted U-shape: outcome risk rose with increasing TSH, reached its maximum at TSH values that progressively shifted upward with increasing age (from 1.70 mU/L at age 80 to about 2.20 mUI/L at age 90), then started to decrease. A linear inverse association was found between FT3 and unfavorable discharge setting. Our study suggests that measurement of TFT on SU admission can provide independent prognostic information for early outcomes of acute IS in older euthyroid patients." @default.
• W1994029062 created "2016-06-24" @default.
• W1994029062 creator A5001281881 @default.
• W1994029062 creator A5009091792 @default.
• W1994029062 creator A5010487468 @default.
• W1994029062 creator A5035219505 @default.
• W1994029062 creator A5041785978 @default.
• W1994029062 creator A5050072263 @default.
• W1994029062 creator A5050171140 @default.
• W1994029062 creator A5081035761 @default.
• W1994029062 creator A5086502594 @default.
• W1994029062 date "2015-01-01" @default.
• W1994029062 modified "2023-09-26" @default.
• W1994029062 title "Thyroid function tests and early outcomes of acute ischemic stroke in older euthyroid patients" @default.
• W1994029062 cites W1554044559 @default.
• W1994029062 cites W1686405222 @default.
• W1994029062 cites W1966516758 @default.
• W1994029062 cites W1969661146 @default.
• W1994029062 cites W1978327859 @default.
• W1994029062 cites W1980651541 @default.
• W1994029062 cites W1984888466 @default.
• W1994029062 cites W1989926032 @default.
• W1994029062 cites W1994922079 @default.
• W1994029062 cites W2000445173 @default.
• W1994029062 cites W2000461166 @default.
• W1994029062 cites W2022419831 @default.
• W1994029062 cites W2023419475 @default.
• W1994029062 cites W2028938818 @default.
• W1994029062 cites W2033555047 @default.
• W1994029062 cites W2036774036 @default.
• W1994029062 cites W2043015190 @default.
• W1994029062 cites W2047159776 @default.
• W1994029062 cites W2052899850 @default.
• W1994029062 cites W2063633162 @default.
• W1994029062 cites W2064799866 @default.
• W1994029062 cites W2075016273 @default.
• W1994029062 cites W2078103827 @default.
• W1994029062 cites W2080504768 @default.
• W1994029062 cites W2086234277 @default.
• W1994029062 cites W2087177155 @default.
• W1994029062 cites W2094144656 @default.
• W1994029062 cites W2097931334 @default.
• W1994029062 cites W2098761773 @default.
• W1994029062 cites W2101745268 @default.
• W1994029062 cites W2105577839 @default.
• W1994029062 cites W2107116656 @default.
• W1994029062 cites W2112873367 @default.
• W1994029062 cites W2113483913 @default.
• W1994029062 cites W2119583377 @default.
• W1994029062 cites W2131972331 @default.
• W1994029062 cites W2133618685 @default.
• W1994029062 cites W2145833261 @default.
• W1994029062 cites W2152059169 @default.
• W1994029062 cites W2158866006 @default.
• W1994029062 cites W2167941855 @default.
• W1994029062 cites W2168760648 @default.
• W1994029062 cites W2170006972 @default.
• W1994029062 cites W2329359534 @default.
• W1994029062 doi "https://doi.org/10.1016/j.exger.2014.11.011" @default.
• W1994029062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25449856" @default.
• W1994029062 hasPublicationYear "2015" @default.
• W1994029062 type Work @default.
• W1994029062 sameAs 1994029062 @default.
• W1994029062 citedByCount "22" @default.
• W1994029062 countsByYear W19940290622015 @default.
• W1994029062 countsByYear W19940290622016 @default.
• W1994029062 countsByYear W19940290622017 @default.
• W1994029062 countsByYear W19940290622018 @default.
• W1994029062 countsByYear W19940290622019 @default.
• W1994029062 countsByYear W19940290622020 @default.
• W1994029062 countsByYear W19940290622021 @default.
• W1994029062 countsByYear W19940290622022 @default.
• W1994029062 countsByYear W19940290622023 @default.
• W1994029062 crossrefType "journal-article" @default.
• W1994029062 hasAuthorship W1994029062A5001281881 @default.
• W1994029062 hasAuthorship W1994029062A5009091792 @default.
• W1994029062 hasAuthorship W1994029062A5010487468 @default.
• W1994029062 hasAuthorship W1994029062A5035219505 @default.
• W1994029062 hasAuthorship W1994029062A5041785978 @default.
• W1994029062 hasAuthorship W1994029062A5050072263 @default.
• W1994029062 hasAuthorship W1994029062A5050171140 @default.
• W1994029062 hasAuthorship W1994029062A5081035761 @default.
• W1994029062 hasAuthorship W1994029062A5086502594 @default.
• W1994029062 hasConcept C126322002 @default.
• W1994029062 hasConcept C127413603 @default.
• W1994029062 hasConcept C151956035 @default.
• W1994029062 hasConcept C187212893 @default.
• W1994029062 hasConcept C2777195454 @default.
• W1994029062 hasConcept C2777316304 @default.
• W1994029062 hasConcept C2778840127 @default.
• W1994029062 hasConcept C2780645631 @default.
• W1994029062 hasConcept C2993291352 @default.
• W1994029062 hasConcept C526584372 @default.
• W1994029062 hasConcept C71924100 @default.
• W1994029062 hasConcept C77350462 @default.
• W1994029062 hasConcept C78519656 @default.
• W1994029062 hasConceptScore W1994029062C126322002 @default.
• W1994029062 hasConceptScore W1994029062C127413603 @default.

• next