Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994489695> ?p ?o ?g. }
- W1994489695 endingPage "5311" @default.
- W1994489695 startingPage "5300" @default.
- W1994489695 abstract "Abstract Hydroxyurea has many characteristics of an ideal drug for sickle cell anemia (SCA) and provides therapeutic benefit through multiple mechanisms of action. Over the past 25 years, substantial experience has accumulated regarding its safety and efficacy for patients with SCA. Early proof-of-principle studies were followed by prospective phase 1/2 trials demonstrating efficacy in affected adults, then adolescents and children, and more recently infants and toddlers. The phase 3 National Heart, Lung and Blood Institute–sponsored Multicenter Study of Hydroxyurea trial proved clinical efficacy for preventing acute vaso-occlusive events in severely affected adults. Based on this cumulative experience, hydroxyurea has emerged as an important therapeutic option for children and adolescents with recurrent vaso-occlusive events; recent evidence documents sustained long-term benefits with prevention or reversal of chronic organ damage. Despite abundant evidence for its efficacy, however, hydroxyurea has not yet translated into effective therapy for SCA. Because many healthcare providers have inadequate knowledge about hydroxyurea, patients and families are not offered treatment or decline because of unrealistic fears. Limited support for hydroxyurea by lay organizations and inconsistent medical delivery systems also contribute to underuse. Although questions remain regarding its long-term risks and benefits, current evidence suggests that many young patients with SCA should receive hydroxyurea treatment." @default.
- W1994489695 created "2016-06-24" @default.
- W1994489695 creator A5040752648 @default.
- W1994489695 date "2010-07-01" @default.
- W1994489695 modified "2023-10-10" @default.
- W1994489695 title "How I use hydroxyurea to treat young patients with sickle cell anemia" @default.
- W1994489695 cites W117828388 @default.
- W1994489695 cites W1509226676 @default.
- W1994489695 cites W1719867626 @default.
- W1994489695 cites W1924448383 @default.
- W1994489695 cites W1963802507 @default.
- W1994489695 cites W1963845367 @default.
- W1994489695 cites W1966651742 @default.
- W1994489695 cites W1975364175 @default.
- W1994489695 cites W1975951312 @default.
- W1994489695 cites W1976593240 @default.
- W1994489695 cites W1977627543 @default.
- W1994489695 cites W1978444866 @default.
- W1994489695 cites W1979830619 @default.
- W1994489695 cites W1980933059 @default.
- W1994489695 cites W1982989569 @default.
- W1994489695 cites W1983407529 @default.
- W1994489695 cites W1987058597 @default.
- W1994489695 cites W1989590429 @default.
- W1994489695 cites W1989872169 @default.
- W1994489695 cites W1990926485 @default.
- W1994489695 cites W1992349722 @default.
- W1994489695 cites W1993847169 @default.
- W1994489695 cites W2010997166 @default.
- W1994489695 cites W2012020901 @default.
- W1994489695 cites W2012618051 @default.
- W1994489695 cites W2013392029 @default.
- W1994489695 cites W2015491862 @default.
- W1994489695 cites W2019018139 @default.
- W1994489695 cites W2019578579 @default.
- W1994489695 cites W2022246541 @default.
- W1994489695 cites W2025172439 @default.
- W1994489695 cites W2030505752 @default.
- W1994489695 cites W2033040678 @default.
- W1994489695 cites W2035127684 @default.
- W1994489695 cites W2039423483 @default.
- W1994489695 cites W2043655469 @default.
- W1994489695 cites W2045690184 @default.
- W1994489695 cites W2049129790 @default.
- W1994489695 cites W2057708045 @default.
- W1994489695 cites W2060653840 @default.
- W1994489695 cites W2064816037 @default.
- W1994489695 cites W2065697585 @default.
- W1994489695 cites W2067381623 @default.
- W1994489695 cites W2068926989 @default.
- W1994489695 cites W2070879341 @default.
- W1994489695 cites W2072783023 @default.
- W1994489695 cites W207387586 @default.
- W1994489695 cites W2074023285 @default.
- W1994489695 cites W2074858698 @default.
- W1994489695 cites W2076963154 @default.
- W1994489695 cites W2077174747 @default.
- W1994489695 cites W2081879282 @default.
- W1994489695 cites W2082061899 @default.
- W1994489695 cites W2086622628 @default.
- W1994489695 cites W2089165596 @default.
- W1994489695 cites W2089488867 @default.
- W1994489695 cites W2094967472 @default.
- W1994489695 cites W2111221288 @default.
- W1994489695 cites W2116839902 @default.
- W1994489695 cites W2117811406 @default.
- W1994489695 cites W2120115029 @default.
- W1994489695 cites W2140272338 @default.
- W1994489695 cites W2140950812 @default.
- W1994489695 cites W2143927179 @default.
- W1994489695 cites W2147182596 @default.
- W1994489695 cites W2153336025 @default.
- W1994489695 cites W2159105194 @default.
- W1994489695 cites W2160308620 @default.
- W1994489695 cites W2163042186 @default.
- W1994489695 cites W2164765120 @default.
- W1994489695 cites W2166862811 @default.
- W1994489695 cites W2167241499 @default.
- W1994489695 cites W2169024890 @default.
- W1994489695 cites W2170318163 @default.
- W1994489695 cites W2170995347 @default.
- W1994489695 cites W2313541759 @default.
- W1994489695 cites W2334263927 @default.
- W1994489695 cites W2339887069 @default.
- W1994489695 cites W2406196817 @default.
- W1994489695 cites W2594867548 @default.
- W1994489695 cites W3023245875 @default.
- W1994489695 cites W3093093377 @default.
- W1994489695 cites W4241694836 @default.
- W1994489695 cites W4249661998 @default.
- W1994489695 cites W4249969224 @default.
- W1994489695 cites W4293174344 @default.
- W1994489695 cites W4376542792 @default.
- W1994489695 cites W4860913 @default.
- W1994489695 cites W82508867 @default.
- W1994489695 cites W83314201 @default.
- W1994489695 doi "https://doi.org/10.1182/blood-2009-04-146852" @default.
- W1994489695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2902131" @default.