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- W1994550966 abstract "The standard dose of clofarabine is 52 mg/m2 for pediatrics and 40 mg/m2 in adults. Clofarabine dosed at 52 mg/m2 was used in adult patients with refractory ALL to maximize response before allo-HSCT. All patients had a significant response to therapy. Published pharmacokinetic analysis revealed no difference in peak plasma or intracellular concentrations at clofarabine dosed above 40 mg/m2, yet inhibition of replication in leukemia cells was only sustained over 24 hr at 55 mg/m2. Despite this, there have been no reports of high dose clofarabine used in this setting. Our experience implies that there may be a niche role for clofarabine in reducing disease burden before allo-HSCT for adults with relapsed ALL." @default.
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- W1994550966 date "2009-04-01" @default.
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- W1994550966 title "The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia" @default.
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- W1994550966 doi "https://doi.org/10.1002/ajh.21365" @default.
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