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• W1994629432 abstract "ABSTRACT We analyzed the role of integrons in the dissemination of antibiotic resistance in a recent multiresistant clinical isolate, Serratia marcescens SCH88050909 (SCH909). This isolate harbors three integrons, all on a 60-kb conjugative plasmid. By PCR, hybridization, and sequencing analyses, we found that integron 1 has the dfrA1 and ant ( 3 ) -Ia cassettes. The first cassette in integron 2 contains the ant ( 2 ) -Ia gene, separated from its attC site (59-base element) by a 1,971-bp insert containing a group II intron; this intron codes for a putative maturase-reverse transcriptase on the complementary strand and is the first such intron to be found associated with an integron. The attC site is followed by a novel aminoglycoside resistance gene, ant ( 3 ) -Ii-aac ( 6 ′) -IId , which has been characterized for its bifunctional ANT(3)-I and AAC(6′)-II activities. DNA sequence analysis of this fused cassette suggests that insertion and excision due to the integrase activity could have an important role in the evolution of aminoglycoside resistance genes. This gene is followed by an unknown open reading frame with a typical attC site and a partial cassette composed of the beginning of the bla OXA-10 cassette interrupted by IS 1 . The sequence downstream of IS 1 revealed that the bla OXA-10 cassette is incomplete and that the 3′ conserved segment of this integron is absent. Integron 3 is in a Tn 1696 -like transposon with the aac ( 3 ) -Ia cassette followed by three unknown cassettes and ant ( 3 ) -Ia . The presence of the group II intron and the relationship of group II introns in eubacteria with mobile elements suggest a possible role of this element in events such as cassette formation and/or plasmid evolution." @default.
• W1994629432 created "2016-06-24" @default.
• W1994629432 creator A5050667345 @default.
• W1994629432 creator A5077744347 @default.
• W1994629432 date "2002-05-01" @default.
• W1994629432 modified "2023-09-26" @default.
• W1994629432 title "Presence of a Group II Intron in a Multiresistant <i>Serratia marcescens</i> Strain That Harbors Three Integrons and a Novel Gene Fusion" @default.
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• W1994629432 doi "https://doi.org/10.1128/aac.46.5.1402-1409.2002" @default.
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