Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995217894> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1995217894 endingPage "679" @default.
- W1995217894 startingPage "679" @default.
- W1995217894 abstract "The pharmacokinetics of total platinum (Pt) were investigated after a single oral dose of (OC-6-43-bis(acetato)(1-adamantylamine)amminedichloroplatinum (IV) (LA-12). A dose of 3 mg/kg (n = 3) and 30 mg/kg (n = 3) was given to two parallel groups of pigs (n = three each). Pt was measured in the blood, urine and feces by atomic absorption spectrometry. Blood was sampled at specified times until 240 h, urine was obtained through a catheter at 1-h intervals until 6 h, and feces were collected until 240 h after administration. LA-12 was rapidly absorbed, as indicated by a T(max) of total Pt within 0.5-1.5 h after administration. The mean (SEM) values for maximum plasma concentration (0.060 +/- 0.025 and 0.39 +/- 0.08 mg/l) and the area under the plasma concentration vs. time curve (12.6 +/- 5.6 and 36.3 +/- 2.0 mg.h/l) increased less than proportionally to the increase in the dose. The mean (SEM) Pt urinary excretion determined over a 6-h postdose period achieved only 1.9% and 0.8% of the administered doses, respectively. Within 2 h after dosing, the renal clearance of total Pt was approximately 2-fold higher than that of creatinine (CL(cr)). Thereafter, it steadily dropped and in the last collection interval (5-6 h postdose) its value was 50% less than CL(cr). Platinum recoveries in feces over 10 days after dosing reached 0.4% and 2.6% of the administered dose, respectively. This finding indicates that the extent of absorption of both doses was high. There were no changes in results of hematology and clinical biochemistry tests." @default.
- W1995217894 created "2016-06-24" @default.
- W1995217894 creator A5005786452 @default.
- W1995217894 creator A5019466045 @default.
- W1995217894 creator A5032386718 @default.
- W1995217894 creator A5035857477 @default.
- W1995217894 creator A5046694741 @default.
- W1995217894 creator A5048955063 @default.
- W1995217894 creator A5061183072 @default.
- W1995217894 creator A5080308614 @default.
- W1995217894 date "2004-01-01" @default.
- W1995217894 modified "2023-09-26" @default.
- W1995217894 title "Single-dose pharmacokinetics of a novel oral platinum cytostatic drug ([OC-6-43]-bis[acetato][1-adamantylamine]amminedichloroplatinum [IV]) in pigs" @default.
- W1995217894 doi "https://doi.org/10.1358/mf.2004.26.9.872565" @default.
- W1995217894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15632953" @default.
- W1995217894 hasPublicationYear "2004" @default.
- W1995217894 type Work @default.
- W1995217894 sameAs 1995217894 @default.
- W1995217894 citedByCount "9" @default.
- W1995217894 crossrefType "journal-article" @default.
- W1995217894 hasAuthorship W1995217894A5005786452 @default.
- W1995217894 hasAuthorship W1995217894A5019466045 @default.
- W1995217894 hasAuthorship W1995217894A5032386718 @default.
- W1995217894 hasAuthorship W1995217894A5035857477 @default.
- W1995217894 hasAuthorship W1995217894A5046694741 @default.
- W1995217894 hasAuthorship W1995217894A5048955063 @default.
- W1995217894 hasAuthorship W1995217894A5061183072 @default.
- W1995217894 hasAuthorship W1995217894A5080308614 @default.
- W1995217894 hasConcept C10146269 @default.
- W1995217894 hasConcept C112705442 @default.
- W1995217894 hasConcept C125287762 @default.
- W1995217894 hasConcept C140793950 @default.
- W1995217894 hasConcept C151730666 @default.
- W1995217894 hasConcept C159985019 @default.
- W1995217894 hasConcept C178790620 @default.
- W1995217894 hasConcept C185592680 @default.
- W1995217894 hasConcept C192562407 @default.
- W1995217894 hasConcept C2777056448 @default.
- W1995217894 hasConcept C2777288759 @default.
- W1995217894 hasConcept C2780026642 @default.
- W1995217894 hasConcept C2780306776 @default.
- W1995217894 hasConcept C43617362 @default.
- W1995217894 hasConcept C55493867 @default.
- W1995217894 hasConcept C61716771 @default.
- W1995217894 hasConcept C71924100 @default.
- W1995217894 hasConcept C86803240 @default.
- W1995217894 hasConcept C98274493 @default.
- W1995217894 hasConceptScore W1995217894C10146269 @default.
- W1995217894 hasConceptScore W1995217894C112705442 @default.
- W1995217894 hasConceptScore W1995217894C125287762 @default.
- W1995217894 hasConceptScore W1995217894C140793950 @default.
- W1995217894 hasConceptScore W1995217894C151730666 @default.
- W1995217894 hasConceptScore W1995217894C159985019 @default.
- W1995217894 hasConceptScore W1995217894C178790620 @default.
- W1995217894 hasConceptScore W1995217894C185592680 @default.
- W1995217894 hasConceptScore W1995217894C192562407 @default.
- W1995217894 hasConceptScore W1995217894C2777056448 @default.
- W1995217894 hasConceptScore W1995217894C2777288759 @default.
- W1995217894 hasConceptScore W1995217894C2780026642 @default.
- W1995217894 hasConceptScore W1995217894C2780306776 @default.
- W1995217894 hasConceptScore W1995217894C43617362 @default.
- W1995217894 hasConceptScore W1995217894C55493867 @default.
- W1995217894 hasConceptScore W1995217894C61716771 @default.
- W1995217894 hasConceptScore W1995217894C71924100 @default.
- W1995217894 hasConceptScore W1995217894C86803240 @default.
- W1995217894 hasConceptScore W1995217894C98274493 @default.
- W1995217894 hasIssue "9" @default.
- W1995217894 hasLocation W19952178941 @default.
- W1995217894 hasLocation W19952178942 @default.
- W1995217894 hasOpenAccess W1995217894 @default.
- W1995217894 hasPrimaryLocation W19952178941 @default.
- W1995217894 hasRelatedWork W1925982542 @default.
- W1995217894 hasRelatedWork W2004325424 @default.
- W1995217894 hasRelatedWork W2009246547 @default.
- W1995217894 hasRelatedWork W2020575060 @default.
- W1995217894 hasRelatedWork W2056371746 @default.
- W1995217894 hasRelatedWork W2317172319 @default.
- W1995217894 hasRelatedWork W2318353920 @default.
- W1995217894 hasRelatedWork W2342434199 @default.
- W1995217894 hasRelatedWork W2361304870 @default.
- W1995217894 hasRelatedWork W2793520024 @default.
- W1995217894 hasVolume "26" @default.
- W1995217894 isParatext "false" @default.
- W1995217894 isRetracted "false" @default.
- W1995217894 magId "1995217894" @default.
- W1995217894 workType "article" @default.