FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1995770014> ?p ?o ?g. }

• W1995770014 endingPage "13514" @default.
• W1995770014 startingPage "13508" @default.
• W1995770014 abstract "ABSTRACT Porcine circovirus type 2 (PCV2) capsid protein (CP) is the only protein necessary for the formation of the virion capsid, and recombinant CP spontaneously forms virus-like particles (VLPs). Located within a single CP subunit is an immunodominant epitope consisting of residues 169 to 180 [CP(169–180)], which is exposed on the surface of the subunit, but, in the structural context of the VLP, the epitope is buried and inaccessible to antibody. High levels of anti-CP(169–180) activity are associated with porcine circovirus-associated disease (PCVAD). The purpose of this study was to investigate the role of the immune response to monomer CP in the development of PCVAD. The approach was to immunize pigs with CP monomer, followed by challenge with PCV2 and porcine reproductive and respiratory syndrome virus (PRRSV). To maintain the CP immunogen as a stable monomer, CP(43–233) was fused to ubiquitin (Ub-CP). Size exclusion chromatography showed that Ub-CP was present as a single 33-kDa protein. Pigs immunized with Ub-CP developed a strong antibody response to PCV2, including antibodies against CP(169–180). However, only low levels of virus neutralizing activity were detected, and viremia levels were similar to those of nonimmunized pigs. As a positive control, immunization with baculovirus-expressed CP (Bac-CP) resulted in high levels of virus neutralizing activity, small amounts of anti-CP(169–180) activity, and the absence of viremia in pigs following virus challenge. The data support the role of CP(169–180) as an immunological decoy and illustrate the importance of the structural form of the CP immunogen in determining the outcome following infection." @default.
• W1995770014 created "2016-06-24" @default.
• W1995770014 creator A5002131351 @default.
• W1995770014 creator A5025864599 @default.
• W1995770014 creator A5039586618 @default.
• W1995770014 creator A5075288916 @default.
• W1995770014 creator A5090180411 @default.
• W1995770014 creator A5090507330 @default.
• W1995770014 date "2012-12-15" @default.
• W1995770014 modified "2023-09-27" @default.
• W1995770014 title "Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2" @default.
• W1995770014 cites W1971233211 @default.
• W1995770014 cites W1979958344 @default.
• W1995770014 cites W1980039136 @default.
• W1995770014 cites W1981826497 @default.
• W1995770014 cites W1987698120 @default.
• W1995770014 cites W1989295132 @default.
• W1995770014 cites W1990559162 @default.
• W1995770014 cites W1996313933 @default.
• W1995770014 cites W2003908145 @default.
• W1995770014 cites W2010495206 @default.
• W1995770014 cites W2011043840 @default.
• W1995770014 cites W2012923573 @default.
• W1995770014 cites W2018494804 @default.
• W1995770014 cites W2020954544 @default.
• W1995770014 cites W2021082618 @default.
• W1995770014 cites W2026577124 @default.
• W1995770014 cites W2043865110 @default.
• W1995770014 cites W2060605949 @default.
• W1995770014 cites W2065974702 @default.
• W1995770014 cites W2081983857 @default.
• W1995770014 cites W2100072399 @default.
• W1995770014 cites W2101236493 @default.
• W1995770014 cites W2104181855 @default.
• W1995770014 cites W2105624689 @default.
• W1995770014 cites W2109774002 @default.
• W1995770014 cites W2111970919 @default.
• W1995770014 cites W2129627687 @default.
• W1995770014 cites W2132629607 @default.
• W1995770014 cites W2134324053 @default.
• W1995770014 cites W2136567289 @default.
• W1995770014 cites W2144215066 @default.
• W1995770014 cites W2146555324 @default.
• W1995770014 cites W2147026505 @default.
• W1995770014 cites W2149672821 @default.
• W1995770014 cites W2153314219 @default.
• W1995770014 cites W2156579741 @default.
• W1995770014 cites W2160693757 @default.
• W1995770014 cites W2165673174 @default.
• W1995770014 cites W2166989061 @default.
• W1995770014 cites W2168268569 @default.
• W1995770014 cites W4238945854 @default.
• W1995770014 cites W4252005423 @default.
• W1995770014 doi "https://doi.org/10.1128/jvi.01763-12" @default.
• W1995770014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3503079" @default.
• W1995770014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23035215" @default.
• W1995770014 hasPublicationYear "2012" @default.
• W1995770014 type Work @default.
• W1995770014 sameAs 1995770014 @default.
• W1995770014 citedByCount "48" @default.
• W1995770014 countsByYear W19957700142013 @default.
• W1995770014 countsByYear W19957700142014 @default.
• W1995770014 countsByYear W19957700142015 @default.
• W1995770014 countsByYear W19957700142016 @default.
• W1995770014 countsByYear W19957700142017 @default.
• W1995770014 countsByYear W19957700142018 @default.
• W1995770014 countsByYear W19957700142019 @default.
• W1995770014 countsByYear W19957700142020 @default.
• W1995770014 countsByYear W19957700142021 @default.
• W1995770014 countsByYear W19957700142022 @default.
• W1995770014 countsByYear W19957700142023 @default.
• W1995770014 crossrefType "journal-article" @default.
• W1995770014 hasAuthorship W1995770014A5002131351 @default.
• W1995770014 hasAuthorship W1995770014A5025864599 @default.
• W1995770014 hasAuthorship W1995770014A5039586618 @default.
• W1995770014 hasAuthorship W1995770014A5075288916 @default.
• W1995770014 hasAuthorship W1995770014A5090180411 @default.
• W1995770014 hasAuthorship W1995770014A5090507330 @default.
• W1995770014 hasBestOaLocation W19957700141 @default.
• W1995770014 hasConcept C104292427 @default.
• W1995770014 hasConcept C104317684 @default.
• W1995770014 hasConcept C153911025 @default.
• W1995770014 hasConcept C159047783 @default.
• W1995770014 hasConcept C159654299 @default.
• W1995770014 hasConcept C195616568 @default.
• W1995770014 hasConcept C202878990 @default.
• W1995770014 hasConcept C203014093 @default.
• W1995770014 hasConcept C2522874641 @default.
• W1995770014 hasConcept C2776185481 @default.
• W1995770014 hasConcept C2779231742 @default.
• W1995770014 hasConcept C2779261636 @default.
• W1995770014 hasConcept C2779819720 @default.
• W1995770014 hasConcept C2779909307 @default.
• W1995770014 hasConcept C2781045504 @default.
• W1995770014 hasConcept C2993140218 @default.
• W1995770014 hasConcept C542903549 @default.
• W1995770014 hasConcept C55493867 @default.
• W1995770014 hasConcept C86803240 @default.

• next