Matches in SemOpenAlex for { <https://semopenalex.org/work/W1996260544> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1996260544 endingPage "1743" @default.
- W1996260544 startingPage "1738" @default.
- W1996260544 abstract "In vitro steroid production by a virilizing Sertoli-Leydig cell tumor of the ovary was studied. For comparison, stromal tissue from the opposite normal ovary was also incubated under similar conditions. The tumor fragments secreted significantly more testosterone (527 +/- 168 versus 48 +/- 29 pg/mg tissue, p less than 0.001), androstenedione (1188 +/- 400 versus 40 +/- 10 pg/mg tissue, p less than 0.001), and dehydroepiandrosterone (419 +/- 132 versus 73 +/- 25 pg/mg tissue, p less than 0.004) than that of normal ovarian stroma. Measurement of steroids in the ovarian venous serum draining the tumor indicated a peripheral ovarian gradient for both delta 4 and delta 5 steroids. Incubation of tumor fragments with luteinizing hormone alone resulted in a significant increase in the secretion of androstenedione and dehydroepiandrosterone (p less than 0.05). Addition of insulin to luteinizing hormone resulted in significantly greater release of androstenedione than that of treatment with luteinizing hormone alone (p less than 0.04). Addition of insulin had no effect on the release of dehydroepiandrosterone. Luteinizing hormone and insulin, either alone or in combination, failed to produce any change in the secretion of testosterone. We conclude that (1) increased testosterone secretion by Sertoli-Leydig cell tumor resulted from increased availability of precursors from both delta 4 and delta 5 pathways; (2) the tumor was responsive to luteinizing hormone with an increase in the secretion of androstenedione and dehydroepiandrosterone; (3) insulin acts synergistically with luteinizing hormone to increase secretion of androstenedione; (4) the tumor has specific binding sites for insulin; and (5) the increased levels of insulin and luteinizing hormone in polycystic ovarian disease may play a role in the pathogenesis of Sertoli-Leydig cell tumor." @default.
- W1996260544 created "2016-06-24" @default.
- W1996260544 creator A5004298135 @default.
- W1996260544 creator A5005633362 @default.
- W1996260544 creator A5052997576 @default.
- W1996260544 date "1989-12-01" @default.
- W1996260544 modified "2023-09-25" @default.
- W1996260544 title "Steroid biosynthesis in the Sertoli-Leydig cell tumor: Effects of insulin and luteinizing hormone" @default.
- W1996260544 cites W140762203 @default.
- W1996260544 cites W1480810179 @default.
- W1996260544 cites W1618051355 @default.
- W1996260544 cites W1622354423 @default.
- W1996260544 cites W2013816062 @default.
- W1996260544 cites W2023467920 @default.
- W1996260544 cites W2047127542 @default.
- W1996260544 cites W2057427077 @default.
- W1996260544 cites W2064695540 @default.
- W1996260544 cites W2073999862 @default.
- W1996260544 cites W2077788201 @default.
- W1996260544 cites W2087286513 @default.
- W1996260544 cites W2108728675 @default.
- W1996260544 cites W2118213707 @default.
- W1996260544 cites W2136265774 @default.
- W1996260544 cites W2140190314 @default.
- W1996260544 cites W2151629242 @default.
- W1996260544 cites W2203128389 @default.
- W1996260544 cites W2921053686 @default.
- W1996260544 doi "https://doi.org/10.1016/0002-9378(89)90960-5" @default.
- W1996260544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2532472" @default.
- W1996260544 hasPublicationYear "1989" @default.
- W1996260544 type Work @default.
- W1996260544 sameAs 1996260544 @default.
- W1996260544 citedByCount "12" @default.
- W1996260544 countsByYear W19962605442014 @default.
- W1996260544 countsByYear W19962605442015 @default.
- W1996260544 countsByYear W19962605442016 @default.
- W1996260544 crossrefType "journal-article" @default.
- W1996260544 hasAuthorship W1996260544A5004298135 @default.
- W1996260544 hasAuthorship W1996260544A5005633362 @default.
- W1996260544 hasAuthorship W1996260544A5052997576 @default.
- W1996260544 hasConcept C123765429 @default.
- W1996260544 hasConcept C126322002 @default.
- W1996260544 hasConcept C134018914 @default.
- W1996260544 hasConcept C2776683971 @default.
- W1996260544 hasConcept C2776992908 @default.
- W1996260544 hasConcept C2777736315 @default.
- W1996260544 hasConcept C2777911890 @default.
- W1996260544 hasConcept C2778575703 @default.
- W1996260544 hasConcept C2779279991 @default.
- W1996260544 hasConcept C2779306644 @default.
- W1996260544 hasConcept C2781068068 @default.
- W1996260544 hasConcept C71315377 @default.
- W1996260544 hasConcept C71924100 @default.
- W1996260544 hasConcept C86803240 @default.
- W1996260544 hasConceptScore W1996260544C123765429 @default.
- W1996260544 hasConceptScore W1996260544C126322002 @default.
- W1996260544 hasConceptScore W1996260544C134018914 @default.
- W1996260544 hasConceptScore W1996260544C2776683971 @default.
- W1996260544 hasConceptScore W1996260544C2776992908 @default.
- W1996260544 hasConceptScore W1996260544C2777736315 @default.
- W1996260544 hasConceptScore W1996260544C2777911890 @default.
- W1996260544 hasConceptScore W1996260544C2778575703 @default.
- W1996260544 hasConceptScore W1996260544C2779279991 @default.
- W1996260544 hasConceptScore W1996260544C2779306644 @default.
- W1996260544 hasConceptScore W1996260544C2781068068 @default.
- W1996260544 hasConceptScore W1996260544C71315377 @default.
- W1996260544 hasConceptScore W1996260544C71924100 @default.
- W1996260544 hasConceptScore W1996260544C86803240 @default.
- W1996260544 hasIssue "6" @default.
- W1996260544 hasLocation W19962605441 @default.
- W1996260544 hasLocation W19962605442 @default.
- W1996260544 hasOpenAccess W1996260544 @default.
- W1996260544 hasPrimaryLocation W19962605441 @default.
- W1996260544 hasRelatedWork W1984559885 @default.
- W1996260544 hasRelatedWork W1986311037 @default.
- W1996260544 hasRelatedWork W1987914672 @default.
- W1996260544 hasRelatedWork W1992141591 @default.
- W1996260544 hasRelatedWork W2012070670 @default.
- W1996260544 hasRelatedWork W2014027373 @default.
- W1996260544 hasRelatedWork W2024718203 @default.
- W1996260544 hasRelatedWork W2036404189 @default.
- W1996260544 hasRelatedWork W2050826448 @default.
- W1996260544 hasRelatedWork W2144746424 @default.
- W1996260544 hasVolume "161" @default.
- W1996260544 isParatext "false" @default.
- W1996260544 isRetracted "false" @default.
- W1996260544 magId "1996260544" @default.
- W1996260544 workType "article" @default.