FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998094729> ?p ?o ?g. }

• W1998094729 endingPage "595" @default.
• W1998094729 startingPage "587" @default.
• W1998094729 abstract "Scleroderma [also known as systemic sclerosis (SSc)] is a complex autoimmune disease characterised by pathological remodelling of connective tissues. Although the earliest and most frequent manifestations include blood vessel and immunological abnormalities, the systemic and progressive pathology suggests that fundamental interactions between microvascular damage and inflammation are mechanistically linked to obliterative tissue fibrosis. This review will focus on how model systems have provided clues to these relationships and will discuss new data from the study of novel animal disease models. These reveal how vascular damage and leukocyte accumulation generate the molecular cues that control the profiles of soluble mediators, which regulate the aberrant behaviour of mesenchymal cells within connective tissues, and how the dysregulated expression of these components and their differentiation contribute to the persistent fibrogenic response. Scleroderma [also known as systemic sclerosis (SSc)] is a complex autoimmune disease characterised by pathological remodelling of connective tissues. Although the earliest and most frequent manifestations include blood vessel and immunological abnormalities, the systemic and progressive pathology suggests that fundamental interactions between microvascular damage and inflammation are mechanistically linked to obliterative tissue fibrosis. This review will focus on how model systems have provided clues to these relationships and will discuss new data from the study of novel animal disease models. These reveal how vascular damage and leukocyte accumulation generate the molecular cues that control the profiles of soluble mediators, which regulate the aberrant behaviour of mesenchymal cells within connective tissues, and how the dysregulated expression of these components and their differentiation contribute to the persistent fibrogenic response." @default.
• W1998094729 created "2016-06-24" @default.
• W1998094729 creator A5012966437 @default.
• W1998094729 creator A5015770154 @default.
• W1998094729 date "2005-11-01" @default.
• W1998094729 modified "2023-10-18" @default.
• W1998094729 title "Scleroderma: from cell and molecular mechanisms to disease models" @default.
• W1998094729 cites W1527967512 @default.
• W1998094729 cites W1583239878 @default.
• W1998094729 cites W1913068299 @default.
• W1998094729 cites W1952126894 @default.
• W1998094729 cites W1968015805 @default.
• W1998094729 cites W1970443971 @default.
• W1998094729 cites W1971638473 @default.
• W1998094729 cites W1979973473 @default.
• W1998094729 cites W1981927941 @default.
• W1998094729 cites W1982579492 @default.
• W1998094729 cites W1983273975 @default.
• W1998094729 cites W1991875226 @default.
• W1998094729 cites W1992213652 @default.
• W1998094729 cites W1994681981 @default.
• W1998094729 cites W1998424002 @default.
• W1998094729 cites W1998975199 @default.
• W1998094729 cites W2004708987 @default.
• W1998094729 cites W2004913444 @default.
• W1998094729 cites W2016193552 @default.
• W1998094729 cites W2018128871 @default.
• W1998094729 cites W2019127485 @default.
• W1998094729 cites W2019597863 @default.
• W1998094729 cites W2029196046 @default.
• W1998094729 cites W2030725785 @default.
• W1998094729 cites W2035653659 @default.
• W1998094729 cites W2036614725 @default.
• W1998094729 cites W2036969566 @default.
• W1998094729 cites W2039204046 @default.
• W1998094729 cites W2042606264 @default.
• W1998094729 cites W2047673714 @default.
• W1998094729 cites W2053912050 @default.
• W1998094729 cites W2057033794 @default.
• W1998094729 cites W2058088461 @default.
• W1998094729 cites W2059390959 @default.
• W1998094729 cites W2063991533 @default.
• W1998094729 cites W2065907626 @default.
• W1998094729 cites W2066193611 @default.
• W1998094729 cites W2067245803 @default.
• W1998094729 cites W2068593104 @default.
• W1998094729 cites W2069702053 @default.
• W1998094729 cites W2071160767 @default.
• W1998094729 cites W2071298419 @default.
• W1998094729 cites W2072708404 @default.
• W1998094729 cites W2076190000 @default.
• W1998094729 cites W2077239805 @default.
• W1998094729 cites W2078220103 @default.
• W1998094729 cites W2081735284 @default.
• W1998094729 cites W2085339199 @default.
• W1998094729 cites W2094836033 @default.
• W1998094729 cites W2098109071 @default.
• W1998094729 cites W2100274551 @default.
• W1998094729 cites W2105573863 @default.
• W1998094729 cites W2109677617 @default.
• W1998094729 cites W2115637648 @default.
• W1998094729 cites W2122808924 @default.
• W1998094729 cites W2125736097 @default.
• W1998094729 cites W2125881724 @default.
• W1998094729 cites W2132114985 @default.
• W1998094729 cites W2138211373 @default.
• W1998094729 cites W2146064625 @default.
• W1998094729 cites W2154568166 @default.
• W1998094729 cites W2169551162 @default.
• W1998094729 cites W2327755610 @default.
• W1998094729 cites W2407571930 @default.
• W1998094729 cites W4234049385 @default.
• W1998094729 cites W4250731522 @default.
• W1998094729 doi "https://doi.org/10.1016/j.it.2005.09.004" @default.
• W1998094729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16168711" @default.
• W1998094729 hasPublicationYear "2005" @default.
• W1998094729 type Work @default.
• W1998094729 sameAs 1998094729 @default.
• W1998094729 citedByCount "257" @default.
• W1998094729 countsByYear W19980947292012 @default.
• W1998094729 countsByYear W19980947292013 @default.
• W1998094729 countsByYear W19980947292014 @default.
• W1998094729 countsByYear W19980947292015 @default.
• W1998094729 countsByYear W19980947292016 @default.
• W1998094729 countsByYear W19980947292017 @default.
• W1998094729 countsByYear W19980947292018 @default.
• W1998094729 countsByYear W19980947292019 @default.
• W1998094729 countsByYear W19980947292020 @default.
• W1998094729 countsByYear W19980947292021 @default.
• W1998094729 countsByYear W19980947292022 @default.
• W1998094729 countsByYear W19980947292023 @default.
• W1998094729 crossrefType "journal-article" @default.
• W1998094729 hasAuthorship W1998094729A5012966437 @default.
• W1998094729 hasAuthorship W1998094729A5015770154 @default.
• W1998094729 hasConcept C142724271 @default.
• W1998094729 hasConcept C180032290 @default.
• W1998094729 hasConcept C198826908 @default.
• W1998094729 hasConcept C203014093 @default.

• next