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- W1998493498 abstract "Autism spectrum disorder (ASD) is a disease of neuro-developmental origin of uncertain etiology. The current understanding is that both genetic and environmental factors contribute to the development of ASD. Exposure to valproate, thalidomide and alcohol during gestation are amongst the environmental triggers that are associated with the development of ASD. These teratogens may disturb the ontogeny of the brain by altering the expression pattern of genes that regulate the normal development of the brain. In this study, a neuron-like PC-12 cell model was used to examine the effects of these compounds on the binding potential of 50 different transcription factors to understand the molecular mechanism/s that may be involved in the teratogenesis caused by these agents. Cells in culture were treated with low or high concentrations of teratogens within a range that are reported in the blood of individuals. A pronounced increase in GATA transcription factor binding was observed for all three teratogens. Furthermore, Western blot analysis showed that GATA-3 level in the nuclear fractions was enhanced by each of the three teratogens. Results suggest that altered gene expression pattern due to heightened GATA-3 activities in the fetral brains following exposure to these teratogens may contribute to the development of ASD." @default.
- W1998493498 created "2016-06-24" @default.
- W1998493498 creator A5005026171 @default.
- W1998493498 creator A5027056057 @default.
- W1998493498 date "2009-06-01" @default.
- W1998493498 modified "2023-09-24" @default.
- W1998493498 title "Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders" @default.
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- W1998493498 cites W1608846710 @default.
- W1998493498 cites W1649213427 @default.
- W1998493498 cites W1870365463 @default.
- W1998493498 cites W1967456872 @default.
- W1998493498 cites W1973018580 @default.
- W1998493498 cites W1973828234 @default.
- W1998493498 cites W1977890658 @default.
- W1998493498 cites W1981603375 @default.
- W1998493498 cites W1983141299 @default.
- W1998493498 cites W1989196651 @default.
- W1998493498 cites W2000958534 @default.
- W1998493498 cites W2001410149 @default.
- W1998493498 cites W2001768156 @default.
- W1998493498 cites W2005199599 @default.
- W1998493498 cites W2007216198 @default.
- W1998493498 cites W2008300544 @default.
- W1998493498 cites W2013837694 @default.
- W1998493498 cites W2015487963 @default.
- W1998493498 cites W2015925048 @default.
- W1998493498 cites W2016111184 @default.
- W1998493498 cites W2017025091 @default.
- W1998493498 cites W2021279972 @default.
- W1998493498 cites W2021949850 @default.
- W1998493498 cites W2038991236 @default.
- W1998493498 cites W2039449654 @default.
- W1998493498 cites W2040708659 @default.
- W1998493498 cites W2042297319 @default.
- W1998493498 cites W2043365657 @default.
- W1998493498 cites W2043757605 @default.
- W1998493498 cites W2046929032 @default.
- W1998493498 cites W2051534092 @default.
- W1998493498 cites W2053441451 @default.
- W1998493498 cites W2053909439 @default.
- W1998493498 cites W2055535109 @default.
- W1998493498 cites W2056843474 @default.
- W1998493498 cites W2062759190 @default.
- W1998493498 cites W2068468110 @default.
- W1998493498 cites W2069106140 @default.
- W1998493498 cites W2073211623 @default.
- W1998493498 cites W2073332854 @default.
- W1998493498 cites W2075439987 @default.
- W1998493498 cites W2078679648 @default.
- W1998493498 cites W2079290252 @default.
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- W1998493498 cites W2086745302 @default.
- W1998493498 cites W2096463787 @default.
- W1998493498 cites W2104818594 @default.
- W1998493498 cites W2105245235 @default.
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- W1998493498 cites W2141752230 @default.
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- W1998493498 cites W2152471910 @default.
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- W1998493498 doi "https://doi.org/10.1016/j.neures.2009.02.009" @default.
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