FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000281122> ?p ?o ?g. }

• W2000281122 endingPage "2468" @default.
• W2000281122 startingPage "2460" @default.
• W2000281122 abstract "RARA (retinoic acid receptor alpha) haploinsufficiency is an invariable consequence of t(15;17)(q22;q21) translocations in acute promyelocytic leukemia (APL). Retinoids and RARA activity have been implicated in hematopoietic self-renewal and neutrophil maturation. We and others therefore predicted that RARA haploinsufficiency would contribute to APL pathogenesis. To test this hypothesis, we crossed Rara(+/-) mice with mice expressing PML (promyelocytic leukemia)-RARA from the cathepsin G locus (mCG-PR). We found that Rara haploinsufficiency cooperated with PML-RARA, but only modestly influenced the preleukemic and leukemic phenotype. Bone marrow from mCG-PR(+/-) × Rara(+/-) mice had decreased numbers of mature myeloid cells, increased ex vivo myeloid cell proliferation, and increased competitive advantage after transplantation. Rara haploinsufficiency did not alter mCG-PR-dependent leukemic latency or penetrance, but did influence the distribution of leukemic cells; leukemia in mCG-PR(+/-) × Rara(+/-) mice presented more commonly with low to normal white blood cell counts and with myeloid infiltration of lymph nodes. APL cells from these mice were responsive to all-trans retinoic acid and had virtually no differences in expression profiling compared with tumors arising in mCG-PR(+/-) × Rara(+/+) mice. These data show that Rara haploinsufficiency (like Pml haploinsufficiency and RARA-PML) can cooperate with PML-RARA to influence the pathogenesis of APL in mice, but that PML-RARA is the t(15;17) disease-initiating mutation." @default.
• W2000281122 created "2016-06-24" @default.
• W2000281122 creator A5031896350 @default.
• W2000281122 creator A5041753570 @default.
• W2000281122 creator A5042552121 @default.
• W2000281122 creator A5076598094 @default.
• W2000281122 creator A5081851296 @default.
• W2000281122 date "2011-02-24" @default.
• W2000281122 modified "2023-09-30" @default.
• W2000281122 title "Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice" @default.
• W2000281122 cites W100159771 @default.
• W2000281122 cites W1550111480 @default.
• W2000281122 cites W1579062391 @default.
• W2000281122 cites W1750460473 @default.
• W2000281122 cites W1972332158 @default.
• W2000281122 cites W1977783851 @default.
• W2000281122 cites W1983925806 @default.
• W2000281122 cites W1989867979 @default.
• W2000281122 cites W1998572012 @default.
• W2000281122 cites W2000131861 @default.
• W2000281122 cites W2005498869 @default.
• W2000281122 cites W2005557419 @default.
• W2000281122 cites W2010410555 @default.
• W2000281122 cites W2012661561 @default.
• W2000281122 cites W2013520247 @default.
• W2000281122 cites W2016087553 @default.
• W2000281122 cites W2019506693 @default.
• W2000281122 cites W2029928472 @default.
• W2000281122 cites W2034618235 @default.
• W2000281122 cites W2036050417 @default.
• W2000281122 cites W2053417914 @default.
• W2000281122 cites W2053657365 @default.
• W2000281122 cites W2066789082 @default.
• W2000281122 cites W2079526924 @default.
• W2000281122 cites W2083720592 @default.
• W2000281122 cites W2086666061 @default.
• W2000281122 cites W2092623151 @default.
• W2000281122 cites W2093674089 @default.
• W2000281122 cites W2096433887 @default.
• W2000281122 cites W2101779426 @default.
• W2000281122 cites W2101824868 @default.
• W2000281122 cites W2120102447 @default.
• W2000281122 cites W2125733324 @default.
• W2000281122 cites W2141471973 @default.
• W2000281122 cites W2150054925 @default.
• W2000281122 cites W2153680238 @default.
• W2000281122 cites W2258222863 @default.
• W2000281122 cites W2323921384 @default.
• W2000281122 cites W333692773 @default.
• W2000281122 cites W4230032786 @default.
• W2000281122 doi "https://doi.org/10.1182/blood-2010-08-300087" @default.
• W2000281122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3317790" @default.
• W2000281122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21190992" @default.
• W2000281122 hasPublicationYear "2011" @default.
• W2000281122 type Work @default.
• W2000281122 sameAs 2000281122 @default.
• W2000281122 citedByCount "12" @default.
• W2000281122 countsByYear W20002811222012 @default.
• W2000281122 countsByYear W20002811222013 @default.
• W2000281122 countsByYear W20002811222014 @default.
• W2000281122 countsByYear W20002811222016 @default.
• W2000281122 countsByYear W20002811222018 @default.
• W2000281122 countsByYear W20002811222019 @default.
• W2000281122 countsByYear W20002811222021 @default.
• W2000281122 countsByYear W20002811222023 @default.
• W2000281122 crossrefType "journal-article" @default.
• W2000281122 hasAuthorship W2000281122A5031896350 @default.
• W2000281122 hasAuthorship W2000281122A5041753570 @default.
• W2000281122 hasAuthorship W2000281122A5042552121 @default.
• W2000281122 hasAuthorship W2000281122A5076598094 @default.
• W2000281122 hasAuthorship W2000281122A5081851296 @default.
• W2000281122 hasBestOaLocation W20002811221 @default.
• W2000281122 hasConcept C104317684 @default.
• W2000281122 hasConcept C127716648 @default.
• W2000281122 hasConcept C203014093 @default.
• W2000281122 hasConcept C2776601000 @default.
• W2000281122 hasConcept C2778461978 @default.
• W2000281122 hasConcept C2778729363 @default.
• W2000281122 hasConcept C2779282312 @default.
• W2000281122 hasConcept C2780007613 @default.
• W2000281122 hasConcept C2781121885 @default.
• W2000281122 hasConcept C502942594 @default.
• W2000281122 hasConcept C54355233 @default.
• W2000281122 hasConcept C68838962 @default.
• W2000281122 hasConcept C86803240 @default.
• W2000281122 hasConceptScore W2000281122C104317684 @default.
• W2000281122 hasConceptScore W2000281122C127716648 @default.
• W2000281122 hasConceptScore W2000281122C203014093 @default.
• W2000281122 hasConceptScore W2000281122C2776601000 @default.
• W2000281122 hasConceptScore W2000281122C2778461978 @default.
• W2000281122 hasConceptScore W2000281122C2778729363 @default.
• W2000281122 hasConceptScore W2000281122C2779282312 @default.
• W2000281122 hasConceptScore W2000281122C2780007613 @default.
• W2000281122 hasConceptScore W2000281122C2781121885 @default.
• W2000281122 hasConceptScore W2000281122C502942594 @default.
• W2000281122 hasConceptScore W2000281122C54355233 @default.
• W2000281122 hasConceptScore W2000281122C68838962 @default.
• W2000281122 hasConceptScore W2000281122C86803240 @default.

• next