Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001025157> ?p ?o ?g. }
- W2001025157 endingPage "385" @default.
- W2001025157 startingPage "376" @default.
- W2001025157 abstract "Arterial spin labeling (ASL) perfusion fMRI is an emerging method in clinical neuroimaging. Its non-invasiveness, absence of low frequency noise, and ability to quantify the absolute level of cerebral blood flow (CBF) make the method ideal for longitudinal designs or low frequency paradigms. Despite the usefulness in the study of cognitive dysfunctions in clinical populations, perfusion activation studies to date have been conducted for simple sensorimotor paradigms or with single-slice acquisition, mainly due to technical challenges. Using our recently developed amplitude-modulated continuous ASL (CASL) perfusion fMRI protocol, we assessed the feasibility of a higher level cognitive activation study in twelve healthy subjects. Taking advantage of the ASL noise properties, we were able to study tonic CBF changes during uninterrupted 6-min continuous performance of working memory and sustained attention tasks. For the visual sustained attention task, regional CBF increases (6–12 ml/100 g/min) were detected in the right middle frontal gyrus, the bilateral occipital gyri, and the anterior cingulate/medial frontal gyri. During the 2-back working memory task, significantly increased activations (7–11 ml/100 g/min) were found in the left inferior frontal/precentral gyri, the left inferior parietal lobule, the anterior cingulate/medial frontal gyri, and the left occipital gyrus. Locations of activated and deactivated areas largely concur with previous PET and BOLD fMRI studies utilizing similar paradigms. These results demonstrate that CASL perfusion fMRI can be successfully utilized for the investigation of the tonic CBF changes associated with high level cognitive operations. Increased applications of the method to the investigation of cognitively impaired populations are expected to follow." @default.
- W2001025157 created "2016-06-24" @default.
- W2001025157 creator A5022571351 @default.
- W2001025157 creator A5038335088 @default.
- W2001025157 creator A5058192322 @default.
- W2001025157 creator A5066687350 @default.
- W2001025157 creator A5076843491 @default.
- W2001025157 creator A5079792922 @default.
- W2001025157 date "2006-05-01" @default.
- W2001025157 modified "2023-10-18" @default.
- W2001025157 title "Continuous ASL perfusion fMRI investigation of higher cognition: Quantification of tonic CBF changes during sustained attention and working memory tasks" @default.
- W2001025157 cites W1871190058 @default.
- W2001025157 cites W189785350 @default.
- W2001025157 cites W1955896372 @default.
- W2001025157 cites W1967031555 @default.
- W2001025157 cites W1970346097 @default.
- W2001025157 cites W1973374608 @default.
- W2001025157 cites W1979935501 @default.
- W2001025157 cites W1981685168 @default.
- W2001025157 cites W1983209930 @default.
- W2001025157 cites W1985026505 @default.
- W2001025157 cites W1985980415 @default.
- W2001025157 cites W1987225560 @default.
- W2001025157 cites W1989854445 @default.
- W2001025157 cites W1991434325 @default.
- W2001025157 cites W1994184572 @default.
- W2001025157 cites W1995204763 @default.
- W2001025157 cites W1997569528 @default.
- W2001025157 cites W2000444603 @default.
- W2001025157 cites W2000697043 @default.
- W2001025157 cites W2002007413 @default.
- W2001025157 cites W2002660165 @default.
- W2001025157 cites W2006362157 @default.
- W2001025157 cites W2007069475 @default.
- W2001025157 cites W2009325812 @default.
- W2001025157 cites W2012735958 @default.
- W2001025157 cites W2020694953 @default.
- W2001025157 cites W2021620877 @default.
- W2001025157 cites W2023609264 @default.
- W2001025157 cites W2024073199 @default.
- W2001025157 cites W2029524616 @default.
- W2001025157 cites W2034230590 @default.
- W2001025157 cites W2037543554 @default.
- W2001025157 cites W2044634376 @default.
- W2001025157 cites W2048052171 @default.
- W2001025157 cites W2050634056 @default.
- W2001025157 cites W2051509186 @default.
- W2001025157 cites W2054714223 @default.
- W2001025157 cites W2056081184 @default.
- W2001025157 cites W2057376755 @default.
- W2001025157 cites W2060124423 @default.
- W2001025157 cites W2063237661 @default.
- W2001025157 cites W2065371566 @default.
- W2001025157 cites W2065876528 @default.
- W2001025157 cites W2069293080 @default.
- W2001025157 cites W2071401512 @default.
- W2001025157 cites W2071617207 @default.
- W2001025157 cites W2077562203 @default.
- W2001025157 cites W2081203319 @default.
- W2001025157 cites W2081246497 @default.
- W2001025157 cites W2083986155 @default.
- W2001025157 cites W2087599214 @default.
- W2001025157 cites W2088774650 @default.
- W2001025157 cites W2099660465 @default.
- W2001025157 cites W2100560187 @default.
- W2001025157 cites W2106706293 @default.
- W2001025157 cites W2111240150 @default.
- W2001025157 cites W2111927756 @default.
- W2001025157 cites W2112720824 @default.
- W2001025157 cites W2114931946 @default.
- W2001025157 cites W2117752070 @default.
- W2001025157 cites W2118560750 @default.
- W2001025157 cites W2120321712 @default.
- W2001025157 cites W2121723878 @default.
- W2001025157 cites W2121930833 @default.
- W2001025157 cites W2123719135 @default.
- W2001025157 cites W2127166669 @default.
- W2001025157 cites W2128240756 @default.
- W2001025157 cites W2129815969 @default.
- W2001025157 cites W2131996077 @default.
- W2001025157 cites W2133875665 @default.
- W2001025157 cites W2135304097 @default.
- W2001025157 cites W2136022845 @default.
- W2001025157 cites W2138022605 @default.
- W2001025157 cites W2138131939 @default.
- W2001025157 cites W2141884607 @default.
- W2001025157 cites W2142360036 @default.
- W2001025157 cites W2147089914 @default.
- W2001025157 cites W2147186992 @default.
- W2001025157 cites W2151483049 @default.
- W2001025157 cites W2154535553 @default.
- W2001025157 cites W2157105237 @default.
- W2001025157 cites W2159006998 @default.
- W2001025157 cites W2161846593 @default.
- W2001025157 cites W2169081687 @default.
- W2001025157 cites W2169366712 @default.
- W2001025157 cites W2169598865 @default.
- W2001025157 cites W2170683962 @default.