FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2001044773> ?p ?o ?g. }

• W2001044773 endingPage "698" @default.
• W2001044773 startingPage "681" @default.
• W2001044773 abstract "The myelodysplastic syndromes (MDS) are associated with a diverse set of acquired somatic genetic abnormalities. Bone marrow karyotyping provides important diagnostic and prognostic information and should be attempted in all patients who are suspected of having MDS. Fluorescent in situ hybridization (FISH) studies on blood or marrow may also be valuable in selected cases, such as patients who may have 5q- syndrome or those who have undergone hematopoietic stem cell transplantation. The MDS-associated cytogenetic abnormalities that have been defined by karyotyping and FISH studies have already contributed substantially to our current understanding of the biology of malignant myeloid disorders, but the pathobiological meaning of common, recurrent chromosomal lesions such as del(5q), del(20q), and monosomy 7 is still unknown. The great diversity of the cytogenetic findings described in MDS highlights the molecular heterogeneity of this cluster of diseases. We review the common and pathophysiologically interesting genetic abnormalities associated with MDS, focusing on the clinical utility of conventional cytogenetic assays and selected FISH studies. In addition, we discuss a series of well-defined MDS-associated point mutations and outline the potential for further insights from newer techniques such as global gene expression profiling and array-based comparative genomic hybridization. The myelodysplastic syndromes (MDS) are associated with a diverse set of acquired somatic genetic abnormalities. Bone marrow karyotyping provides important diagnostic and prognostic information and should be attempted in all patients who are suspected of having MDS. Fluorescent in situ hybridization (FISH) studies on blood or marrow may also be valuable in selected cases, such as patients who may have 5q- syndrome or those who have undergone hematopoietic stem cell transplantation. The MDS-associated cytogenetic abnormalities that have been defined by karyotyping and FISH studies have already contributed substantially to our current understanding of the biology of malignant myeloid disorders, but the pathobiological meaning of common, recurrent chromosomal lesions such as del(5q), del(20q), and monosomy 7 is still unknown. The great diversity of the cytogenetic findings described in MDS highlights the molecular heterogeneity of this cluster of diseases. We review the common and pathophysiologically interesting genetic abnormalities associated with MDS, focusing on the clinical utility of conventional cytogenetic assays and selected FISH studies. In addition, we discuss a series of well-defined MDS-associated point mutations and outline the potential for further insights from newer techniques such as global gene expression profiling and array-based comparative genomic hybridization." @default.
• W2001044773 created "2016-06-24" @default.
• W2001044773 creator A5065716888 @default.
• W2001044773 creator A5077104483 @default.
• W2001044773 date "2005-05-01" @default.
• W2001044773 modified "2023-09-28" @default.
• W2001044773 title "Genetic Testing in the Myelodysplastic Syndromes: Molecular Insights Into Hematologic Diversity" @default.
• W2001044773 cites W11426206 @default.
• W2001044773 cites W1541919983 @default.
• W2001044773 cites W1556996865 @default.
• W2001044773 cites W158191276 @default.
• W2001044773 cites W1600695244 @default.
• W2001044773 cites W1723358241 @default.
• W2001044773 cites W1771108404 @default.
• W2001044773 cites W187238933 @default.
• W2001044773 cites W1879966002 @default.
• W2001044773 cites W1929127637 @default.
• W2001044773 cites W1964050328 @default.
• W2001044773 cites W1967110232 @default.
• W2001044773 cites W1968065877 @default.
• W2001044773 cites W1969497532 @default.
• W2001044773 cites W1969676572 @default.
• W2001044773 cites W1971056717 @default.
• W2001044773 cites W1972475837 @default.
• W2001044773 cites W1974217358 @default.
• W2001044773 cites W1975701044 @default.
• W2001044773 cites W1976645406 @default.
• W2001044773 cites W1976765538 @default.
• W2001044773 cites W1976826388 @default.
• W2001044773 cites W1977025294 @default.
• W2001044773 cites W1979820704 @default.
• W2001044773 cites W1979934252 @default.
• W2001044773 cites W1980969183 @default.
• W2001044773 cites W1981978962 @default.
• W2001044773 cites W1982108368 @default.
• W2001044773 cites W1983812739 @default.
• W2001044773 cites W1984825396 @default.
• W2001044773 cites W1984882433 @default.
• W2001044773 cites W1985122748 @default.
• W2001044773 cites W1985301272 @default.
• W2001044773 cites W1985622852 @default.
• W2001044773 cites W1986086620 @default.
• W2001044773 cites W1986389204 @default.
• W2001044773 cites W1986987869 @default.
• W2001044773 cites W1987311483 @default.
• W2001044773 cites W1988475925 @default.
• W2001044773 cites W1991345036 @default.
• W2001044773 cites W1991918209 @default.
• W2001044773 cites W1992089947 @default.
• W2001044773 cites W1992091679 @default.
• W2001044773 cites W1992641700 @default.
• W2001044773 cites W1993931486 @default.
• W2001044773 cites W1996541348 @default.
• W2001044773 cites W1996887331 @default.
• W2001044773 cites W1999617682 @default.
• W2001044773 cites W2001207297 @default.
• W2001044773 cites W2001523905 @default.
• W2001044773 cites W2001979268 @default.
• W2001044773 cites W2002966604 @default.
• W2001044773 cites W2003646197 @default.
• W2001044773 cites W2004878345 @default.
• W2001044773 cites W2005014251 @default.
• W2001044773 cites W2005756814 @default.
• W2001044773 cites W2007042448 @default.
• W2001044773 cites W2007391655 @default.
• W2001044773 cites W2007591475 @default.
• W2001044773 cites W2009993343 @default.
• W2001044773 cites W2014703763 @default.
• W2001044773 cites W2016325390 @default.
• W2001044773 cites W2016401533 @default.
• W2001044773 cites W2016531290 @default.
• W2001044773 cites W2016532523 @default.
• W2001044773 cites W2017714998 @default.
• W2001044773 cites W2019952415 @default.
• W2001044773 cites W2021023649 @default.
• W2001044773 cites W2022733644 @default.
• W2001044773 cites W2023382011 @default.
• W2001044773 cites W2025908815 @default.
• W2001044773 cites W2029732911 @default.
• W2001044773 cites W2034820298 @default.
• W2001044773 cites W2036180570 @default.
• W2001044773 cites W2037479635 @default.
• W2001044773 cites W2037576870 @default.
• W2001044773 cites W2037835894 @default.
• W2001044773 cites W2038569516 @default.
• W2001044773 cites W2039800589 @default.
• W2001044773 cites W2040257851 @default.
• W2001044773 cites W2040521097 @default.
• W2001044773 cites W2041965576 @default.
• W2001044773 cites W2042619574 @default.
• W2001044773 cites W2045131720 @default.
• W2001044773 cites W2048459239 @default.
• W2001044773 cites W2052758951 @default.
• W2001044773 cites W2054769839 @default.
• W2001044773 cites W2055445052 @default.
• W2001044773 cites W2056502554 @default.
• W2001044773 cites W2058164920 @default.
• W2001044773 cites W2058627918 @default.

• next