Matches in SemOpenAlex for { <https://semopenalex.org/work/W2003648558> ?p ?o ?g. }
- W2003648558 endingPage "115" @default.
- W2003648558 startingPage "107" @default.
- W2003648558 abstract "A partial differential equation model is developed to understand the effect that nutrient and acidosis have on the distribution of proliferating and quiescent cells and dead cell material (necrotic and apoptotic) within a multicellular tumour spheroid. The rates of cell quiescence and necrosis depend upon the local nutrient and acid concentrations and quiescent cells are assumed to consume less nutrient and produce less acid than proliferating cells. Analysis of the differences in nutrient consumption and acid production by quiescent and proliferating cells shows low nutrient levels do not necessarily lead to increased acid concentration via anaerobic metabolism. Rather, it is the balance between proliferating and quiescent cells within the tumour which is important; decreased nutrient levels lead to more quiescent cells, which produce less acid than proliferating cells. We examine this effect via a sensitivity analysis which also includes a quantification of the effect that nutrient and acid concentrations have on the rates of cell quiescence and necrosis." @default.
- W2003648558 created "2016-06-24" @default.
- W2003648558 creator A5001578642 @default.
- W2003648558 creator A5025791169 @default.
- W2003648558 creator A5051202360 @default.
- W2003648558 creator A5084775701 @default.
- W2003648558 date "2012-04-01" @default.
- W2003648558 modified "2023-10-16" @default.
- W2003648558 title "Modelling acidosis and the cell cycle in multicellular tumour spheroids" @default.
- W2003648558 cites W1527382852 @default.
- W2003648558 cites W1908801241 @default.
- W2003648558 cites W1953420644 @default.
- W2003648558 cites W1979728048 @default.
- W2003648558 cites W1989103896 @default.
- W2003648558 cites W1995628511 @default.
- W2003648558 cites W200447247 @default.
- W2003648558 cites W2010025550 @default.
- W2003648558 cites W2013317927 @default.
- W2003648558 cites W2018095250 @default.
- W2003648558 cites W2022414551 @default.
- W2003648558 cites W2025521327 @default.
- W2003648558 cites W2026103498 @default.
- W2003648558 cites W2033268422 @default.
- W2003648558 cites W2038750244 @default.
- W2003648558 cites W2043655938 @default.
- W2003648558 cites W2045387133 @default.
- W2003648558 cites W2045484383 @default.
- W2003648558 cites W2048110853 @default.
- W2003648558 cites W2048152819 @default.
- W2003648558 cites W2072119474 @default.
- W2003648558 cites W2074110498 @default.
- W2003648558 cites W2078873934 @default.
- W2003648558 cites W2095186700 @default.
- W2003648558 cites W2105491572 @default.
- W2003648558 cites W2111663010 @default.
- W2003648558 cites W2112938681 @default.
- W2003648558 cites W2114208773 @default.
- W2003648558 cites W2121467746 @default.
- W2003648558 cites W2122995470 @default.
- W2003648558 cites W2125257427 @default.
- W2003648558 cites W2147212734 @default.
- W2003648558 cites W2147266699 @default.
- W2003648558 cites W2151989604 @default.
- W2003648558 cites W2155049174 @default.
- W2003648558 cites W2156687584 @default.
- W2003648558 cites W2319550775 @default.
- W2003648558 cites W2985100448 @default.
- W2003648558 doi "https://doi.org/10.1016/j.jtbi.2011.11.009" @default.
- W2003648558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4010153" @default.
- W2003648558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155133" @default.
- W2003648558 hasPublicationYear "2012" @default.
- W2003648558 type Work @default.
- W2003648558 sameAs 2003648558 @default.
- W2003648558 citedByCount "12" @default.
- W2003648558 countsByYear W20036485582012 @default.
- W2003648558 countsByYear W20036485582013 @default.
- W2003648558 countsByYear W20036485582014 @default.
- W2003648558 countsByYear W20036485582018 @default.
- W2003648558 countsByYear W20036485582019 @default.
- W2003648558 countsByYear W20036485582020 @default.
- W2003648558 countsByYear W20036485582021 @default.
- W2003648558 countsByYear W20036485582023 @default.
- W2003648558 crossrefType "journal-article" @default.
- W2003648558 hasAuthorship W2003648558A5001578642 @default.
- W2003648558 hasAuthorship W2003648558A5025791169 @default.
- W2003648558 hasAuthorship W2003648558A5051202360 @default.
- W2003648558 hasAuthorship W2003648558A5084775701 @default.
- W2003648558 hasBestOaLocation W20036485582 @default.
- W2003648558 hasConcept C142796444 @default.
- W2003648558 hasConcept C1491633281 @default.
- W2003648558 hasConcept C175369904 @default.
- W2003648558 hasConcept C18903297 @default.
- W2003648558 hasConcept C190283241 @default.
- W2003648558 hasConcept C202751555 @default.
- W2003648558 hasConcept C29537977 @default.
- W2003648558 hasConcept C31573885 @default.
- W2003648558 hasConcept C503630168 @default.
- W2003648558 hasConcept C54355233 @default.
- W2003648558 hasConcept C55493867 @default.
- W2003648558 hasConcept C62112901 @default.
- W2003648558 hasConcept C62231903 @default.
- W2003648558 hasConcept C74318829 @default.
- W2003648558 hasConcept C86803240 @default.
- W2003648558 hasConcept C95444343 @default.
- W2003648558 hasConceptScore W2003648558C142796444 @default.
- W2003648558 hasConceptScore W2003648558C1491633281 @default.
- W2003648558 hasConceptScore W2003648558C175369904 @default.
- W2003648558 hasConceptScore W2003648558C18903297 @default.
- W2003648558 hasConceptScore W2003648558C190283241 @default.
- W2003648558 hasConceptScore W2003648558C202751555 @default.
- W2003648558 hasConceptScore W2003648558C29537977 @default.
- W2003648558 hasConceptScore W2003648558C31573885 @default.
- W2003648558 hasConceptScore W2003648558C503630168 @default.
- W2003648558 hasConceptScore W2003648558C54355233 @default.
- W2003648558 hasConceptScore W2003648558C55493867 @default.
- W2003648558 hasConceptScore W2003648558C62112901 @default.
- W2003648558 hasConceptScore W2003648558C62231903 @default.
- W2003648558 hasConceptScore W2003648558C74318829 @default.