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- W2003809571 abstract "Somatic cell hybrids between multipotent mouse teratoma cells and mouse fibroblasts were established and isolated. The hybrid cells possess one chromosome set of each parental type and express major histocompatibility antigens of both strains of mice from which the parental cells were derived. Upon inoculation into F1 mice, hybrid cells produced tumors which were typical fibrosarcomas as were the tumors produced by the fibroblastic parental cell line. None of the well differentiated tissue types characteristic of the teratoma parent cell tumors were expressed in the hybrid tumors. The hybrid tumors possessed the majority of the chromosomes of the two parental cells; however, the modal numbers were slightly reduced in comparison with those of the cell populations inoculated. The possible role of ‘genic balance’ in phenotypic expression of cell hybrids is discussed." @default.
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- W2003809571 date "1973-01-01" @default.
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- W2003809571 title "Lack of expression of differentiation in mouse teratoma-fibroblast somatic cell hybrids" @default.
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- W2003809571 doi "https://doi.org/10.1016/0014-4827(73)90435-7" @default.
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