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• W2004165692 abstract "Hemodynamic and left ventricular function parameters were measured in patients with mild to moderate hypertension and compromised left ventricular function who were given dilevalol, an antihypertensive agent with selective β2-agonism and nonselective β-antagonist activity. After a 2- to 3-week placebo washout period, 9 patients were given dilevalol titrated upward from 100 to 600 mg twice daily over a 7-week period to achieve a supine diastolic blood pressure of < 90 mm Hg with a decrease of ≥10 mm Hg from baseline. Multigated radionuclide ventriculography and systolic and diastolic time intervals were performed after the pretreatment placebo washout, at the end of 2 weeks' maintenance dosing, and after a 7- to 10-day post-treatment discontinuation and placebo washout period. At an average daily dose of dilevalol, 444 mg, heart rate at rest decreased significantly (p < 0.01) during treatment and increased during post-treatment placebo. Systolic and diastolic blood pressures at rest decreased significantly (p < 0.01) during treatment and increased during post-treatment placebo. At maximal exercise, changes in blood pressure and heart rate were significantly blunted (p < 0.05) during treatment. Ejection fraction at rest increased significantly (p < 0.01) during treatment, with no significant change occurring during exercise, and decreased during post-treatment placebo. Preejection period decreased significantly during treatment (p < 0.005) and increased during post-treatment placebo. Left ventricular ejection time increased significantly during treatment (p < 0.01) and decreased during post-treatment placebo, and preejection period/left ventricular ejection time ratio decreased significantly during treatment (p < 0.001), indicating improved ventricular performance, and increased during post-treatment placebo. Diastolic time increased significantly (p < 0.001) during treatment and decreased during post-treatment placebo. These results demonstrate that dilevalol effectively reduced blood pressure and improved left ventricular function in patients with hypertension and left ventricular dysfunction." @default.
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• W2004165692 date "1989-06-01" @default.
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• W2004165692 title "Hemodynamic effects of dilevalol in patients with systemic hypertension and left ventricular dysfunction" @default.
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• W2004165692 doi "https://doi.org/10.1016/0002-9149(89)90132-x" @default.
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