Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006182904> ?p ?o ?g. }
- W2006182904 endingPage "8" @default.
- W2006182904 startingPage "1" @default.
- W2006182904 abstract "Glioblastoma (WHO Grade IV) is both the most common primary brain tumor and the most malignant. Advances in the understanding of the biology of the tumor are needed in order to obtain a clearer picture of the mechanisms driving these tumors. To neuropathologists, glioblastoma is a tumor that represents a complex system of migrating pleomorphic tumor cells, proliferating blood vessels, infiltrating inflammatory cells, and necrosis. This review will highlight how the glioma stem cell concept brings these elements together into a collective whole, interacting with microenvironmental influences in complex ways. Borrowing from chaos theory a vocabulary of “self organizing systems” and “complex adaptive systems” that seem useful in describing these pathologic features, a new paradigm of glioblastoma biology will be proposed that genetic changes should be understood in a three dimensional framework as they relate not only to the tumor cells themselves but also to the multicellular hierarchical unit, not isolated from, but responsive to, its local milieu. In this way we will come to better appreciate the impact our therapeutic interventions have on the regional phenotypic heterogeneity that exists within the tumor and the intercellular communications directing adaptation and progression." @default.
- W2006182904 created "2016-06-24" @default.
- W2006182904 creator A5021296578 @default.
- W2006182904 creator A5073862375 @default.
- W2006182904 date "2011-01-01" @default.
- W2006182904 modified "2023-09-23" @default.
- W2006182904 title "Glioblastoma Stem Cells: A Neuropathologist's View" @default.
- W2006182904 cites W1529084294 @default.
- W2006182904 cites W1953848330 @default.
- W2006182904 cites W1968365367 @default.
- W2006182904 cites W1969676039 @default.
- W2006182904 cites W1970832400 @default.
- W2006182904 cites W1971634938 @default.
- W2006182904 cites W1972700706 @default.
- W2006182904 cites W1998031042 @default.
- W2006182904 cites W2000193607 @default.
- W2006182904 cites W2001544973 @default.
- W2006182904 cites W2009886857 @default.
- W2006182904 cites W2015036988 @default.
- W2006182904 cites W2017965105 @default.
- W2006182904 cites W2018607339 @default.
- W2006182904 cites W2023427658 @default.
- W2006182904 cites W2026801779 @default.
- W2006182904 cites W2031182614 @default.
- W2006182904 cites W2034269086 @default.
- W2006182904 cites W2039075677 @default.
- W2006182904 cites W2045062585 @default.
- W2006182904 cites W2051531582 @default.
- W2006182904 cites W2051588629 @default.
- W2006182904 cites W2053304682 @default.
- W2006182904 cites W2054723025 @default.
- W2006182904 cites W2060080437 @default.
- W2006182904 cites W2060551076 @default.
- W2006182904 cites W2062165914 @default.
- W2006182904 cites W2065786458 @default.
- W2006182904 cites W2069818613 @default.
- W2006182904 cites W2070306500 @default.
- W2006182904 cites W2079888823 @default.
- W2006182904 cites W2083201495 @default.
- W2006182904 cites W2089183416 @default.
- W2006182904 cites W2090350928 @default.
- W2006182904 cites W2090982381 @default.
- W2006182904 cites W2102085111 @default.
- W2006182904 cites W2106105815 @default.
- W2006182904 cites W2108340830 @default.
- W2006182904 cites W2109610561 @default.
- W2006182904 cites W2110265246 @default.
- W2006182904 cites W2115233755 @default.
- W2006182904 cites W2117759507 @default.
- W2006182904 cites W2117767331 @default.
- W2006182904 cites W2119313610 @default.
- W2006182904 cites W2123509170 @default.
- W2006182904 cites W2124078079 @default.
- W2006182904 cites W2124224257 @default.
- W2006182904 cites W2127035464 @default.
- W2006182904 cites W2141016223 @default.
- W2006182904 cites W2142015340 @default.
- W2006182904 cites W2143619463 @default.
- W2006182904 cites W2147535764 @default.
- W2006182904 cites W2152387543 @default.
- W2006182904 cites W2157388625 @default.
- W2006182904 cites W2168414172 @default.
- W2006182904 doi "https://doi.org/10.1155/2011/397195" @default.
- W2006182904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2971570" @default.
- W2006182904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21052560" @default.
- W2006182904 hasPublicationYear "2011" @default.
- W2006182904 type Work @default.
- W2006182904 sameAs 2006182904 @default.
- W2006182904 citedByCount "26" @default.
- W2006182904 countsByYear W20061829042012 @default.
- W2006182904 countsByYear W20061829042013 @default.
- W2006182904 countsByYear W20061829042014 @default.
- W2006182904 countsByYear W20061829042015 @default.
- W2006182904 countsByYear W20061829042016 @default.
- W2006182904 countsByYear W20061829042017 @default.
- W2006182904 countsByYear W20061829042019 @default.
- W2006182904 countsByYear W20061829042020 @default.
- W2006182904 countsByYear W20061829042021 @default.
- W2006182904 countsByYear W20061829042022 @default.
- W2006182904 countsByYear W20061829042023 @default.
- W2006182904 crossrefType "journal-article" @default.
- W2006182904 hasAuthorship W2006182904A5021296578 @default.
- W2006182904 hasAuthorship W2006182904A5073862375 @default.
- W2006182904 hasBestOaLocation W20061829041 @default.
- W2006182904 hasConcept C104317684 @default.
- W2006182904 hasConcept C127716648 @default.
- W2006182904 hasConcept C139807058 @default.
- W2006182904 hasConcept C142724271 @default.
- W2006182904 hasConcept C1491633281 @default.
- W2006182904 hasConcept C169760540 @default.
- W2006182904 hasConcept C2776194525 @default.
- W2006182904 hasConcept C2778227246 @default.
- W2006182904 hasConcept C2779130545 @default.
- W2006182904 hasConcept C28328180 @default.
- W2006182904 hasConcept C3020616263 @default.
- W2006182904 hasConcept C502942594 @default.
- W2006182904 hasConcept C54355233 @default.
- W2006182904 hasConcept C71924100 @default.