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- W2007676864 abstract "The proteins encoded by thep53andNf1tumor suppressor genes are involved in cell signaling and regulation of proliferation during normal development and differentiation, as well as during tumor progression. To characterize the roles of these genes in the proliferation and survival of embryonic neurons, we have used dissociated cultures of sympathetic superior cervical ganglia (SCG) isolated fromp53andNf1single and compound-mutant mouse embryos. We have defined a temporal window for p53 involvement in sympathetic neuron survival and proliferation. Moreover, our results indicate that cooperativity between mutations inNf1andp53prolongs SCG neuron proliferation and increases the incidence of neural tube defects in compound-mutant embryos." @default.
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- W2007676864 date "1998-05-01" @default.
- W2007676864 modified "2023-09-27" @default.
- W2007676864 title "Sympathetic Neuron Survival and Proliferation Are Prolonged by Loss of p53 and Neurofibromin" @default.
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- W2007676864 doi "https://doi.org/10.1006/mcne.1998.0670" @default.
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