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- W2010098800 abstract "Since the development of the first immunoassay for circulating chromogranin A in 1984, a lot of studies have evaluated its clinical impact in neuroendocrine tumors. Initially studied in pheochromocytoma patients, the clinical impact of chromogranin A has rapidly extended to most neuroendocrine tumours, sometimes in combination with other eutopic or ectopic secretions. In our experience, CgA demonstrates a variable sensitivity between NET primary and a high specificity. Our results suggest that CgA should be routinely screened in foregut-derived NET and abandoned in the routine screening of medullary thyroid carcinoma. In addition, in phaeochromocytoma and ileum-NET patients, CgA demonstrates a comparable sensitivity with urinary reference markers and its impact on the follow-up will form a key point when recommending routine screening. Both tumor burden and secretory activity should be taken into account when interpreting CgA results." @default.
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- W2010098800 date "2001-01-01" @default.
- W2010098800 modified "2023-10-14" @default.
- W2010098800 title "Impact of chromogranin A measurement in the work-up of neuroendocrine tumors" @default.
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- W2010098800 doi "https://doi.org/10.1093/annonc/12.suppl_2.s79" @default.
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