FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2010180575> ?p ?o ?g. }

• W2010180575 endingPage "46" @default.
• W2010180575 startingPage "36" @default.
• W2010180575 abstract "We analyzed immune responses in chronically HIV-infected individuals who took part in a treatment interruption (TI) trial designed for patients who initiated antiretroviral therapy within 6 months of seroconversion. In the 2 subjects who exhibited the best viral control, we detected CD8+ T-cell responses against 1-2 Gag epitopes during the early weeks of TI and a subsequent increase in the number of epitopes recognized by the later time points. Each of these subjects developed mutations within the epitopes targeted by the highest magnitude responses. In the subject with the worst viral control, we detected responses against 2 Gag epitopes throughout the entire TI and no Gag mutations. The magnitude of these responses increased dramatically with time, greatly exceeding those detected in the virologic controllers. The highest levels of contemporaneous autologous neutralizing antibody activity were detected in the virologic controllers, and a subsequent escape mutation developed within the envelope gene of one controller that abrogated the response. These data suggest that immune escape mutations are a sign of viral control during TI, and that the absence of immune escape mutations in the presence of high levels of viral replication indicates the lack of an effective host immune response." @default.
• W2010180575 created "2016-06-24" @default.
• W2010180575 creator A5002341035 @default.
• W2010180575 creator A5034553895 @default.
• W2010180575 creator A5042931433 @default.
• W2010180575 creator A5055252960 @default.
• W2010180575 creator A5061011874 @default.
• W2010180575 creator A5080602798 @default.
• W2010180575 creator A5086748531 @default.
• W2010180575 date "2010-01-01" @default.
• W2010180575 modified "2023-09-24" @default.
• W2010180575 title "Immune Escape Mutations Detected Within HIV-1 Epitopes Associated With Viral Control During Treatment Interruption" @default.
• W2010180575 cites W1533478833 @default.
• W2010180575 cites W1574561647 @default.
• W2010180575 cites W1815763197 @default.
• W2010180575 cites W1969133711 @default.
• W2010180575 cites W1976608858 @default.
• W2010180575 cites W1976902082 @default.
• W2010180575 cites W1990768351 @default.
• W2010180575 cites W1996367365 @default.
• W2010180575 cites W2006243025 @default.
• W2010180575 cites W2034160159 @default.
• W2010180575 cites W2046448593 @default.
• W2010180575 cites W2049024332 @default.
• W2010180575 cites W2053695022 @default.
• W2010180575 cites W2054697232 @default.
• W2010180575 cites W2073048104 @default.
• W2010180575 cites W2098739109 @default.
• W2010180575 cites W2102256218 @default.
• W2010180575 cites W2106336618 @default.
• W2010180575 cites W2106882534 @default.
• W2010180575 cites W2111063498 @default.
• W2010180575 cites W2113127537 @default.
• W2010180575 cites W2114290965 @default.
• W2010180575 cites W2119232577 @default.
• W2010180575 cites W2123096807 @default.
• W2010180575 cites W2125072873 @default.
• W2010180575 cites W2125389159 @default.
• W2010180575 cites W2130768495 @default.
• W2010180575 cites W2133866490 @default.
• W2010180575 cites W2142038176 @default.
• W2010180575 cites W2143430982 @default.
• W2010180575 cites W2156110652 @default.
• W2010180575 cites W2156819923 @default.
• W2010180575 cites W2158783859 @default.
• W2010180575 cites W2160925670 @default.
• W2010180575 cites W2170303456 @default.
• W2010180575 cites W2170838597 @default.
• W2010180575 doi "https://doi.org/10.1097/qai.0b013e3181c4b885" @default.
• W2010180575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843510" @default.
• W2010180575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19910798" @default.
• W2010180575 hasPublicationYear "2010" @default.
• W2010180575 type Work @default.
• W2010180575 sameAs 2010180575 @default.
• W2010180575 citedByCount "12" @default.
• W2010180575 countsByYear W20101805752012 @default.
• W2010180575 countsByYear W20101805752014 @default.
• W2010180575 countsByYear W20101805752015 @default.
• W2010180575 countsByYear W20101805752017 @default.
• W2010180575 countsByYear W20101805752020 @default.
• W2010180575 countsByYear W20101805752022 @default.
• W2010180575 crossrefType "journal-article" @default.
• W2010180575 hasAuthorship W2010180575A5002341035 @default.
• W2010180575 hasAuthorship W2010180575A5034553895 @default.
• W2010180575 hasAuthorship W2010180575A5042931433 @default.
• W2010180575 hasAuthorship W2010180575A5055252960 @default.
• W2010180575 hasAuthorship W2010180575A5061011874 @default.
• W2010180575 hasAuthorship W2010180575A5080602798 @default.
• W2010180575 hasAuthorship W2010180575A5086748531 @default.
• W2010180575 hasBestOaLocation W20101805752 @default.
• W2010180575 hasConcept C104317684 @default.
• W2010180575 hasConcept C142462285 @default.
• W2010180575 hasConcept C159047783 @default.
• W2010180575 hasConcept C159654299 @default.
• W2010180575 hasConcept C167672396 @default.
• W2010180575 hasConcept C195616568 @default.
• W2010180575 hasConcept C203014093 @default.
• W2010180575 hasConcept C2522874641 @default.
• W2010180575 hasConcept C2777451964 @default.
• W2010180575 hasConcept C2780648854 @default.
• W2010180575 hasConcept C501734568 @default.
• W2010180575 hasConcept C54355233 @default.
• W2010180575 hasConcept C86803240 @default.
• W2010180575 hasConcept C8891405 @default.
• W2010180575 hasConceptScore W2010180575C104317684 @default.
• W2010180575 hasConceptScore W2010180575C142462285 @default.
• W2010180575 hasConceptScore W2010180575C159047783 @default.
• W2010180575 hasConceptScore W2010180575C159654299 @default.
• W2010180575 hasConceptScore W2010180575C167672396 @default.
• W2010180575 hasConceptScore W2010180575C195616568 @default.
• W2010180575 hasConceptScore W2010180575C203014093 @default.
• W2010180575 hasConceptScore W2010180575C2522874641 @default.
• W2010180575 hasConceptScore W2010180575C2777451964 @default.
• W2010180575 hasConceptScore W2010180575C2780648854 @default.
• W2010180575 hasConceptScore W2010180575C501734568 @default.
• W2010180575 hasConceptScore W2010180575C54355233 @default.
• W2010180575 hasConceptScore W2010180575C86803240 @default.
• W2010180575 hasConceptScore W2010180575C8891405 @default.

• next