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- W2010210149 abstract "Invasive pulmonary aspergillosis (IPA) caused by the ubiquitous environmental fungus Aspergillus is a frequently fatal lung disease of immunocompromised humans accounting for more than 200,000 infections each year, with an associated mortality rate of 30-90%. This review addresses the current status of IPA diagnosis and treatment and the urgent need to develop accurate, non-invasive strategies for identifying pulmonary infections in the ever-expanding population of immune deficient patients at risk of acquiring opportunistic fungal infections including hematological malignancy and hematopoetic stem cell transplant patients. Recent advances in the use of an Aspergillus-specific monoclonal antibody, JF5, for point-of-care diagnosis of IPA using lateral-flow technology is examined, as is its use in PET/MRI bioimaging and radio-immunotherapy using radionuclide-labeled single chain antibody fragments, Fab fragments, and a fully humanized JF5 derivative." @default.
- W2010210149 created "2016-06-24" @default.
- W2010210149 creator A5071663829 @default.
- W2010210149 date "2014-04-01" @default.
- W2010210149 modified "2023-09-26" @default.
- W2010210149 title "Breaking the mould – novel diagnostic and therapeutic strategies for invasive pulmonary aspergillosis in the immune deficient patient" @default.
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- W2010210149 doi "https://doi.org/10.1586/1744666x.2014.904747" @default.
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