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- W2012841114 abstract "Several recent studies provided evidence that PUMA, a pro-apoptotic member of the BH3-only protein subgroup of the Bcl-2 family, is critical for restricting survival and recovery of different cell types, including those of the hematopoietic system, after γ-irradiation (IR)-triggered DNA damage. According to its pro-apoptotic function downstream of p53, PUMA is considered to act as a tumor suppressor. While this expectation was met in a model of oncogene-driven lymphomagenesis or carcinogen-driven tumor formation in the gut, studies on IR-driven tumor formation revealed surprising new insights into the role of p53-triggered and PUMA-mediated apoptosis in tumorigenesis and stem cell homeostasis." @default.
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- W2012841114 date "2010-11-01" @default.
- W2012841114 modified "2023-09-23" @default.
- W2012841114 title "PUMA-mediated tumor suppression: A tale of two stories" @default.
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- W2012841114 doi "https://doi.org/10.4161/cc.9.21.13666" @default.
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