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- W2013236272 abstract "Factors which have been suggested as being of importance in the development of emphysema are discussed and several schemes of pathogenesis composed of various combinations of these factors are reviewed. Recurrent exposure of dogs to sublethal concentration of phosgene gas produces a chronic bronchiolo-alveolitis. Physiologically, these animals show increased airway resistance, increased functional residual capacity and uneven distribution of inspired air, all of which are characteristic of emphysema. After several weeks of such exposure, they also show microscopic changes suggestive of emphysema. These experiments support the hypothesis that recurrent bronchiolo-alveolitis is the basic lesion in emphysema. They may also assist the further understanding of this disease by facilitating study of the correlation between changes in structure and in function and by providing a model in which therapy may be evaluated." @default.
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- W2013236272 date "1965-09-01" @default.
- W2013236272 modified "2023-09-27" @default.
- W2013236272 title "Pathogenesis of Emphysema: Experimental Observations* *From the Departments of Internal Medicine and Pathology, USAF School of Aerospace Medicine, Aerospace Medical Division (AFSC)." @default.
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- W2013236272 doi "https://doi.org/10.1378/chest.48.3.255" @default.
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