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• W2013817745 abstract "Development of controlled, targeted drug delivery systems represents one of the frontier areas of biomaterials science, where a multidisciplinary approach is of direct benefit to human healthcare. We demonstrate herein the potential of sol-gel derived phosphate-based glass for use in drug delivery applications. Our low-temperature sol-gel synthesis of phosphate-based glasses has made it possible to incorporate relatively unstable functional molecules for controlled release. We demonstrate the potential of this approach by incorporating the chemotherapy agent cisplatin in a CaO-Na(2)O-P(2)O(5) glass. X-ray absorption spectroscopy is used to show that the chlorine ligands of cisplatin undergo exchange with oxygen during the synthesis, consistent with binding to the phosphate groups of the sol-gel. UV-visible spectroscopy reveals the subsequent release of cisplatin into an aqueous medium." @default.
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• W2013817745 date "2010-09-06" @default.
• W2013817745 modified "2023-10-08" @default.
• W2013817745 title "Sol–Gel Phosphate-based Glass for Drug Delivery Applications" @default.
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• W2013817745 doi "https://doi.org/10.1177/0885328210380761" @default.
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