Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014100433> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2014100433 endingPage "377" @default.
- W2014100433 startingPage "367" @default.
- W2014100433 abstract "If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information.The first model estimates different covariate-parameter relationships for within- and between-individual variation in covariate values, by splitting the standard covariate model into a baseline covariate (BCOV) effect and a difference from baseline covariate (DCOV) effect. The second model allows the magnitude of the covariate effect to vary between individuals, by inclusion of interindividual variability in the covariate effect. The models were applied to four previously analysed data sets.The models were applied to 10 covariate-parameter relationships and for three of these the first extended model resulted in a significant improvement of the fit. Even when this model did not improve the fit significantly, it provided useful information because the standard covariate model, which assumes within- and between-patient covariate relationships of the same magnitude, was only supported by the data in four cases. The inclusion of BCOV was not supported in two cases and DCOV was unnecessary in three cases. In one case, significantly different, nonzero, relationships were found for DCOV and BCOV. The second extended model was found to be significant for four of the 10 covariate-parameter relationships.On the basis of the examples presented, traditionally made simplifications of covariate-parameter relationships are often inadequate. Extensions to the covariate-parameter relationships that include time-varying covariates have been developed, and their appropriateness and benefits have been described." @default.
- W2014100433 created "2016-06-24" @default.
- W2014100433 creator A5044869227 @default.
- W2014100433 creator A5045334477 @default.
- W2014100433 creator A5070310610 @default.
- W2014100433 creator A5076833839 @default.
- W2014100433 date "2004-10-01" @default.
- W2014100433 modified "2023-10-16" @default.
- W2014100433 title "Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis" @default.
- W2014100433 cites W1525774039 @default.
- W2014100433 cites W1535918788 @default.
- W2014100433 cites W1567187781 @default.
- W2014100433 cites W1607623286 @default.
- W2014100433 cites W1758672554 @default.
- W2014100433 cites W1975923698 @default.
- W2014100433 cites W2015503275 @default.
- W2014100433 cites W2017497252 @default.
- W2014100433 cites W2058210451 @default.
- W2014100433 cites W2059185356 @default.
- W2014100433 cites W2082535104 @default.
- W2014100433 cites W2089437137 @default.
- W2014100433 cites W2102934589 @default.
- W2014100433 cites W2140312560 @default.
- W2014100433 cites W2162213916 @default.
- W2014100433 cites W2167293877 @default.
- W2014100433 cites W2293106582 @default.
- W2014100433 cites W2411450687 @default.
- W2014100433 cites W2439487334 @default.
- W2014100433 doi "https://doi.org/10.1111/j.1365-2125.2004.02170.x" @default.
- W2014100433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1884602" @default.
- W2014100433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15373929" @default.
- W2014100433 hasPublicationYear "2004" @default.
- W2014100433 type Work @default.
- W2014100433 sameAs 2014100433 @default.
- W2014100433 citedByCount "56" @default.
- W2014100433 countsByYear W20141004332012 @default.
- W2014100433 countsByYear W20141004332013 @default.
- W2014100433 countsByYear W20141004332014 @default.
- W2014100433 countsByYear W20141004332015 @default.
- W2014100433 countsByYear W20141004332016 @default.
- W2014100433 countsByYear W20141004332017 @default.
- W2014100433 countsByYear W20141004332018 @default.
- W2014100433 countsByYear W20141004332019 @default.
- W2014100433 countsByYear W20141004332020 @default.
- W2014100433 countsByYear W20141004332021 @default.
- W2014100433 countsByYear W20141004332022 @default.
- W2014100433 countsByYear W20141004332023 @default.
- W2014100433 crossrefType "journal-article" @default.
- W2014100433 hasAuthorship W2014100433A5044869227 @default.
- W2014100433 hasAuthorship W2014100433A5045334477 @default.
- W2014100433 hasAuthorship W2014100433A5070310610 @default.
- W2014100433 hasAuthorship W2014100433A5076833839 @default.
- W2014100433 hasBestOaLocation W20141004332 @default.
- W2014100433 hasConcept C105795698 @default.
- W2014100433 hasConcept C119043178 @default.
- W2014100433 hasConcept C149782125 @default.
- W2014100433 hasConcept C2908647359 @default.
- W2014100433 hasConcept C33923547 @default.
- W2014100433 hasConcept C71924100 @default.
- W2014100433 hasConcept C99454951 @default.
- W2014100433 hasConceptScore W2014100433C105795698 @default.
- W2014100433 hasConceptScore W2014100433C119043178 @default.
- W2014100433 hasConceptScore W2014100433C149782125 @default.
- W2014100433 hasConceptScore W2014100433C2908647359 @default.
- W2014100433 hasConceptScore W2014100433C33923547 @default.
- W2014100433 hasConceptScore W2014100433C71924100 @default.
- W2014100433 hasConceptScore W2014100433C99454951 @default.
- W2014100433 hasIssue "4" @default.
- W2014100433 hasLocation W20141004331 @default.
- W2014100433 hasLocation W20141004332 @default.
- W2014100433 hasLocation W20141004333 @default.
- W2014100433 hasLocation W20141004334 @default.
- W2014100433 hasOpenAccess W2014100433 @default.
- W2014100433 hasPrimaryLocation W20141004331 @default.
- W2014100433 hasRelatedWork W1551611065 @default.
- W2014100433 hasRelatedWork W1599085740 @default.
- W2014100433 hasRelatedWork W1997383317 @default.
- W2014100433 hasRelatedWork W2037749392 @default.
- W2014100433 hasRelatedWork W2074832029 @default.
- W2014100433 hasRelatedWork W2409617670 @default.
- W2014100433 hasRelatedWork W2963128249 @default.
- W2014100433 hasRelatedWork W3124890365 @default.
- W2014100433 hasRelatedWork W2109980432 @default.
- W2014100433 hasRelatedWork W2550468039 @default.
- W2014100433 hasVolume "58" @default.
- W2014100433 isParatext "false" @default.
- W2014100433 isRetracted "false" @default.
- W2014100433 magId "2014100433" @default.
- W2014100433 workType "article" @default.