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• W2014533659 abstract "Previous studies have indicated that there may be a dysregulation of α2-adrenoceptors and imidazoline receptors in depression. This study compares the effects of chronic antidepressant treatment with a serotonin reuptake inhibitor (fluoxetine) versus a noradrenaline reuptake inhibitor (desipramine) on the binding parameters of the platelet imidazoline binding site (subtype I1) and of the platelet α2-adrenoceptor in depressed patients. After 6 weeks of treatment with either antidepressant, platelet I1 binding sites became normalized (i.e. downregulated). A negative correlation was obtained between plasma epinephrine concentrations and platelet α2-adrenoceptor Bmax values within the samples, but no correlation was obtained between any plasma catecholamine and a platelet I1 binding parameter. An additional finding was the increased affinity of α2-adrenoceptors for p125I-clonidine in untreated depressed patients compared to healthy subjects. Because of the density of platelet I1 binding sites was downregulated by both of the antidepressants, we postulate that a decrease in platelet I1 binding site density may be related to an improved state from depression that these antidepressants produce." @default.
• W2014533659 created "2016-06-24" @default.
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• W2014533659 date "1996-05-01" @default.
• W2014533659 modified "2023-09-27" @default.
• W2014533659 title "Platelet I1-imidazoline binding sites are decreased by two dissimilar antidepressant agents in depressed patients" @default.
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• W2014533659 doi "https://doi.org/10.1016/0022-3956(96)00019-2" @default.
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