Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015378797> ?p ?o ?g. }
- W2015378797 endingPage "429" @default.
- W2015378797 startingPage "421" @default.
- W2015378797 abstract "The effect of the active sulphoxide metabolite of the anthelmintic triclabendazole (TCBZ-SX, 15–50 μg ml−1) on the incorporation of radioactively labelled [14C] leucine by adult Fasciola hepatica tissue slices was measured by liquid scintillation counting. In addition, the ability of the microfilament-disrupting drug, cytochalasin B, and the microtubule-disrupting drug, tubulozole-C, to inhibit protein synthesis, was assessed by similar methods and compared with TCBZ-SX. The established protein synthesis inhibitors, cycloheximide and actinomycin D were used as positive controls. All the drugs showed a significant inhibition of protein synthesis, albeit to different extents; however, TCBZ-SX was the most potent, with no significant difference between its effect and that of cycloheximide or actinomycin D. Moreover, the concentration of TCBZ-SX, above 15 μg ml−1, had little further influence on incorporation of [14C] leucine. This investigation demonstrates the inhibitory effect of TCBZ-SX, cytochalasin B and tubulozole-C on protein synthesis in F. hepatica and confirms the qualitative observations made in several previous ultrastructural studies" @default.
- W2015378797 created "2016-06-24" @default.
- W2015378797 creator A5019976133 @default.
- W2015378797 creator A5025321891 @default.
- W2015378797 creator A5042133470 @default.
- W2015378797 date "1995-04-01" @default.
- W2015378797 modified "2023-09-27" @default.
- W2015378797 title "The effect of triclabendazole (“Fasinex”) on protein synthesis by the liver fluke, Fasciola hepatica" @default.
- W2015378797 cites W1564176844 @default.
- W2015378797 cites W1967432902 @default.
- W2015378797 cites W1968653759 @default.
- W2015378797 cites W1969208858 @default.
- W2015378797 cites W1971402177 @default.
- W2015378797 cites W1977742794 @default.
- W2015378797 cites W1985171339 @default.
- W2015378797 cites W1994795924 @default.
- W2015378797 cites W1995022945 @default.
- W2015378797 cites W1998769641 @default.
- W2015378797 cites W2001678988 @default.
- W2015378797 cites W2003992924 @default.
- W2015378797 cites W2008840943 @default.
- W2015378797 cites W2019540294 @default.
- W2015378797 cites W2021005847 @default.
- W2015378797 cites W2023196369 @default.
- W2015378797 cites W2028221207 @default.
- W2015378797 cites W2028754213 @default.
- W2015378797 cites W2029691091 @default.
- W2015378797 cites W2039025686 @default.
- W2015378797 cites W2039451911 @default.
- W2015378797 cites W2041525960 @default.
- W2015378797 cites W2046683563 @default.
- W2015378797 cites W2047459759 @default.
- W2015378797 cites W2047630475 @default.
- W2015378797 cites W2047643572 @default.
- W2015378797 cites W2047858431 @default.
- W2015378797 cites W2050673891 @default.
- W2015378797 cites W2054438788 @default.
- W2015378797 cites W2057035979 @default.
- W2015378797 cites W2058233636 @default.
- W2015378797 cites W2060052480 @default.
- W2015378797 cites W2068864672 @default.
- W2015378797 cites W2076881814 @default.
- W2015378797 cites W2079160908 @default.
- W2015378797 cites W2079245219 @default.
- W2015378797 cites W2093481886 @default.
- W2015378797 cites W2095043545 @default.
- W2015378797 cites W2103204666 @default.
- W2015378797 cites W2120372693 @default.
- W2015378797 cites W2122086182 @default.
- W2015378797 cites W2127238437 @default.
- W2015378797 cites W2165296438 @default.
- W2015378797 cites W2165337446 @default.
- W2015378797 cites W2315286139 @default.
- W2015378797 cites W2338705923 @default.
- W2015378797 cites W4253352715 @default.
- W2015378797 doi "https://doi.org/10.1016/0020-7519(94)00140-j" @default.
- W2015378797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7635617" @default.
- W2015378797 hasPublicationYear "1995" @default.
- W2015378797 type Work @default.
- W2015378797 sameAs 2015378797 @default.
- W2015378797 citedByCount "32" @default.
- W2015378797 countsByYear W20153787972014 @default.
- W2015378797 countsByYear W20153787972015 @default.
- W2015378797 countsByYear W20153787972016 @default.
- W2015378797 countsByYear W20153787972017 @default.
- W2015378797 countsByYear W20153787972018 @default.
- W2015378797 countsByYear W20153787972020 @default.
- W2015378797 countsByYear W20153787972023 @default.
- W2015378797 crossrefType "journal-article" @default.
- W2015378797 hasAuthorship W2015378797A5019976133 @default.
- W2015378797 hasAuthorship W2015378797A5025321891 @default.
- W2015378797 hasAuthorship W2015378797A5042133470 @default.
- W2015378797 hasConcept C13590703 @default.
- W2015378797 hasConcept C142669718 @default.
- W2015378797 hasConcept C1491633281 @default.
- W2015378797 hasConcept C153911025 @default.
- W2015378797 hasConcept C165901193 @default.
- W2015378797 hasConcept C203014093 @default.
- W2015378797 hasConcept C2775995422 @default.
- W2015378797 hasConcept C2776580952 @default.
- W2015378797 hasConcept C2776908094 @default.
- W2015378797 hasConcept C2777856171 @default.
- W2015378797 hasConcept C2777861111 @default.
- W2015378797 hasConcept C2778128677 @default.
- W2015378797 hasConcept C3675279 @default.
- W2015378797 hasConcept C515207424 @default.
- W2015378797 hasConcept C55493867 @default.
- W2015378797 hasConcept C86803240 @default.
- W2015378797 hasConcept C90856448 @default.
- W2015378797 hasConceptScore W2015378797C13590703 @default.
- W2015378797 hasConceptScore W2015378797C142669718 @default.
- W2015378797 hasConceptScore W2015378797C1491633281 @default.
- W2015378797 hasConceptScore W2015378797C153911025 @default.
- W2015378797 hasConceptScore W2015378797C165901193 @default.
- W2015378797 hasConceptScore W2015378797C203014093 @default.
- W2015378797 hasConceptScore W2015378797C2775995422 @default.
- W2015378797 hasConceptScore W2015378797C2776580952 @default.
- W2015378797 hasConceptScore W2015378797C2776908094 @default.