FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015846126> ?p ?o ?g. }

• W2015846126 endingPage "7345" @default.
• W2015846126 startingPage "7336" @default.
• W2015846126 abstract "Somatic cells can be reprogrammed to generate induced pluripotent stem cells (iPSCs) by overexpression of four transcription factors, Oct4, Klf4, Sox2, and c-Myc. However, exogenous expression of pluripotency factors raised concerns for clinical applications. Here, we show that iPS-like cells (iPSLCs) were generated from mouse somatic cells in two steps with small molecule compounds. In the first step, stable intermediate cells were generated from mouse astrocytes by Bmi1. These cells called induced epiblast stem cell (EpiSC)-like cells (iEpiSCLCs) are similar to EpiSCs in terms of expression of specific markers, epigenetic state, and ability to differentiate into three germ layers. In the second step, treatment with MEK/ERK and GSK3 pathway inhibitors in the presence of leukemia inhibitory factor resulted in conversion of iEpiSCLCs into iPSLCs that were similar to mESCs, suggesting that Bmi1 is sufficient to reprogram astrocytes to partially reprogrammed pluripotency. Next, Bmi1 function was replaced with Shh activators (oxysterol and purmorphamine), which demonstrating that combinations of small molecules can compensate for reprogramming factors and are sufficient to directly reprogram mouse somatic cells into iPSLCs. The chemically induced pluripotent stem cell-like cells (ciPSLCs) showed similar gene expression profiles, epigenetic status, and differentiation potentials to mESCs." @default.
• W2015846126 created "2016-06-24" @default.
• W2015846126 creator A5004656794 @default.
• W2015846126 creator A5008134893 @default.
• W2015846126 creator A5009826364 @default.
• W2015846126 creator A5013212963 @default.
• W2015846126 creator A5013947247 @default.
• W2015846126 creator A5020135137 @default.
• W2015846126 creator A5023360051 @default.
• W2015846126 creator A5041741670 @default.
• W2015846126 creator A5043189910 @default.
• W2015846126 creator A5047276810 @default.
• W2015846126 creator A5047689997 @default.
• W2015846126 creator A5053945584 @default.
• W2015846126 creator A5061682089 @default.
• W2015846126 creator A5086328832 @default.
• W2015846126 date "2014-08-01" @default.
• W2015846126 modified "2023-10-07" @default.
• W2015846126 title "Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules" @default.
• W2015846126 cites W1965451377 @default.
• W2015846126 cites W1966101784 @default.
• W2015846126 cites W1969183806 @default.
• W2015846126 cites W1975356421 @default.
• W2015846126 cites W1991037959 @default.
• W2015846126 cites W2011126334 @default.
• W2015846126 cites W2013568009 @default.
• W2015846126 cites W2021050536 @default.
• W2015846126 cites W2029073164 @default.
• W2015846126 cites W2032570745 @default.
• W2015846126 cites W2035518923 @default.
• W2015846126 cites W2038439057 @default.
• W2015846126 cites W2038531539 @default.
• W2015846126 cites W2040252688 @default.
• W2015846126 cites W2041603462 @default.
• W2015846126 cites W2050689355 @default.
• W2015846126 cites W2057641653 @default.
• W2015846126 cites W2059223857 @default.
• W2015846126 cites W2059994807 @default.
• W2015846126 cites W2062118486 @default.
• W2015846126 cites W2064953489 @default.
• W2015846126 cites W2088128367 @default.
• W2015846126 cites W2090260381 @default.
• W2015846126 cites W2101569447 @default.
• W2015846126 cites W2104708641 @default.
• W2015846126 cites W2105241566 @default.
• W2015846126 cites W2110702717 @default.
• W2015846126 cites W2123970448 @default.
• W2015846126 cites W2125987139 @default.
• W2015846126 cites W2141856502 @default.
• W2015846126 cites W2142482111 @default.
• W2015846126 cites W2146447597 @default.
• W2015846126 cites W2148272837 @default.
• W2015846126 cites W2150817988 @default.
• W2015846126 cites W2152483372 @default.
• W2015846126 cites W2153463588 @default.
• W2015846126 cites W2156398116 @default.
• W2015846126 cites W2157156910 @default.
• W2015846126 cites W2161347865 @default.
• W2015846126 doi "https://doi.org/10.1016/j.biomaterials.2014.05.015" @default.
• W2015846126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24881998" @default.
• W2015846126 hasPublicationYear "2014" @default.
• W2015846126 type Work @default.
• W2015846126 sameAs 2015846126 @default.
• W2015846126 citedByCount "33" @default.
• W2015846126 countsByYear W20158461262014 @default.
• W2015846126 countsByYear W20158461262015 @default.
• W2015846126 countsByYear W20158461262016 @default.
• W2015846126 countsByYear W20158461262017 @default.
• W2015846126 countsByYear W20158461262018 @default.
• W2015846126 countsByYear W20158461262019 @default.
• W2015846126 countsByYear W20158461262020 @default.
• W2015846126 countsByYear W20158461262021 @default.
• W2015846126 countsByYear W20158461262023 @default.
• W2015846126 crossrefType "journal-article" @default.
• W2015846126 hasAuthorship W2015846126A5004656794 @default.
• W2015846126 hasAuthorship W2015846126A5008134893 @default.
• W2015846126 hasAuthorship W2015846126A5009826364 @default.
• W2015846126 hasAuthorship W2015846126A5013212963 @default.
• W2015846126 hasAuthorship W2015846126A5013947247 @default.
• W2015846126 hasAuthorship W2015846126A5020135137 @default.
• W2015846126 hasAuthorship W2015846126A5023360051 @default.
• W2015846126 hasAuthorship W2015846126A5041741670 @default.
• W2015846126 hasAuthorship W2015846126A5043189910 @default.
• W2015846126 hasAuthorship W2015846126A5047276810 @default.
• W2015846126 hasAuthorship W2015846126A5047689997 @default.
• W2015846126 hasAuthorship W2015846126A5053945584 @default.
• W2015846126 hasAuthorship W2015846126A5061682089 @default.
• W2015846126 hasAuthorship W2015846126A5086328832 @default.
• W2015846126 hasConcept C104317684 @default.
• W2015846126 hasConcept C107459253 @default.
• W2015846126 hasConcept C129536746 @default.
• W2015846126 hasConcept C134305767 @default.
• W2015846126 hasConcept C143948831 @default.
• W2015846126 hasConcept C145103041 @default.
• W2015846126 hasConcept C148738053 @default.
• W2015846126 hasConcept C1491633281 @default.
• W2015846126 hasConcept C153911025 @default.
• W2015846126 hasConcept C18155467 @default.

• next