FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016120446> ?p ?o ?g. }

• W2016120446 endingPage "191" @default.
• W2016120446 startingPage "182" @default.
• W2016120446 abstract "The aim of this study was to map the entire nerve architecture and sensory neuropeptide content of the rabbit iris. Irises from New Zealand rabbits were stained with antibodies against neuronal-class βIII-tubulin, calcitonin gene-related peptide (CGRP) and substance P (SP), and whole-mount images were acquired to build a two-dimensional view of the iridal nerve architecture. After taking images in time-lapse mode, we observed thick nerves running in the iris stroma close to the anterior epithelia, forming four to five stromal nerve rings from the iris periphery to the pupillary margin and sub-branches that connected with each other, constituting the stromal nerve plexus. In the anterior side, fine divisions derivated from the stromal nerves, forming a nerve network-like structure to innervate the superficial anterior border layer, with the pupillary margin having the densest innervation. In the posterior side, the nerve bundles ran along with the pupil dilator muscle in a radial pattern. The morphology of the iris nerves on both sides changed with pupil size. To obtain the relative content of the neuropeptides in the iris, the specimens were double stained with βIII-tubulin and CGRP or SP antibodies. Relative nerve fiber densities for each fiber population were assessed quantitatively by computer-assisted analysis. On the anterior side, CGRP-positive nerve fibers constituted about 61%, while SP-positive nerves constitute about 30.5%, of the total nerve content, which was expressed as βIII tubulin-positive fibers. In addition, in the anterior stroma of the collarette region, there were non-neuronal cells that were positive for SP. On the posterior side, CGRP-positive nerve fibers were about 69% of total nerve content, while SP constituted only up to 20%. Similarly, in the trigeminal ganglia (TG), the number of CGRP-positive neurons significantly outnumbered those that were positive for SP. Also, all the SP-positive neurons were labeled with CGRP. This is the first study to provide a two-dimensional whole mount and a cross-sectional view of the entire iris nerve architecture. Considering the anatomical location, the high expression of CGRP and SP suggests that these neuropeptides may play a role in the pathogenesis of anterior uveitis, glaucoma, cataracts and chronic ocular pain." @default.
• W2016120446 created "2016-06-24" @default.
• W2016120446 creator A5015926296 @default.
• W2016120446 creator A5062196910 @default.
• W2016120446 date "2015-06-01" @default.
• W2016120446 modified "2023-10-16" @default.
• W2016120446 title "Morphology and neurochemistry of rabbit iris innervation" @default.
• W2016120446 cites W1485306310 @default.
• W2016120446 cites W1534862699 @default.
• W2016120446 cites W1587886687 @default.
• W2016120446 cites W1650183152 @default.
• W2016120446 cites W1968016071 @default.
• W2016120446 cites W1970048441 @default.
• W2016120446 cites W1982402889 @default.
• W2016120446 cites W1983711728 @default.
• W2016120446 cites W1983972336 @default.
• W2016120446 cites W1986682347 @default.
• W2016120446 cites W1992250586 @default.
• W2016120446 cites W1992916777 @default.
• W2016120446 cites W1993204693 @default.
• W2016120446 cites W1995435454 @default.
• W2016120446 cites W1996413213 @default.
• W2016120446 cites W1996480247 @default.
• W2016120446 cites W2001202192 @default.
• W2016120446 cites W2001385401 @default.
• W2016120446 cites W2008981622 @default.
• W2016120446 cites W2014360373 @default.
• W2016120446 cites W2020335694 @default.
• W2016120446 cites W2024189352 @default.
• W2016120446 cites W2031219030 @default.
• W2016120446 cites W2035581625 @default.
• W2016120446 cites W2035945039 @default.
• W2016120446 cites W2037758748 @default.
• W2016120446 cites W2038078887 @default.
• W2016120446 cites W2044047233 @default.
• W2016120446 cites W2050635513 @default.
• W2016120446 cites W2051296824 @default.
• W2016120446 cites W2053277833 @default.
• W2016120446 cites W2055999131 @default.
• W2016120446 cites W2056858516 @default.
• W2016120446 cites W2057100530 @default.
• W2016120446 cites W2060175573 @default.
• W2016120446 cites W2063116792 @default.
• W2016120446 cites W2063221327 @default.
• W2016120446 cites W2066072069 @default.
• W2016120446 cites W2069252221 @default.
• W2016120446 cites W207345882 @default.
• W2016120446 cites W2081175739 @default.
• W2016120446 cites W2090137648 @default.
• W2016120446 cites W2093610880 @default.
• W2016120446 cites W2125257449 @default.
• W2016120446 cites W2142154103 @default.
• W2016120446 cites W2160767885 @default.
• W2016120446 cites W2164213196 @default.
• W2016120446 cites W2464621343 @default.
• W2016120446 cites W53283566 @default.
• W2016120446 cites W75566844 @default.
• W2016120446 cites W99804252 @default.
• W2016120446 doi "https://doi.org/10.1016/j.exer.2015.03.005" @default.
• W2016120446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4741101" @default.
• W2016120446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25752697" @default.
• W2016120446 hasPublicationYear "2015" @default.
• W2016120446 type Work @default.
• W2016120446 sameAs 2016120446 @default.
• W2016120446 citedByCount "3" @default.
• W2016120446 countsByYear W20161204462016 @default.
• W2016120446 countsByYear W20161204462017 @default.
• W2016120446 countsByYear W20161204462018 @default.
• W2016120446 crossrefType "journal-article" @default.
• W2016120446 hasAuthorship W2016120446A5015926296 @default.
• W2016120446 hasAuthorship W2016120446A5062196910 @default.
• W2016120446 hasBestOaLocation W20161204462 @default.
• W2016120446 hasConcept C105702510 @default.
• W2016120446 hasConcept C118303440 @default.
• W2016120446 hasConcept C142724271 @default.
• W2016120446 hasConcept C163170386 @default.
• W2016120446 hasConcept C16930146 @default.
• W2016120446 hasConcept C170493617 @default.
• W2016120446 hasConcept C184297639 @default.
• W2016120446 hasConcept C2776823239 @default.
• W2016120446 hasConcept C2777723521 @default.
• W2016120446 hasConcept C2779503344 @default.
• W2016120446 hasConcept C2779988585 @default.
• W2016120446 hasConcept C2908647359 @default.
• W2016120446 hasConcept C38652104 @default.
• W2016120446 hasConcept C41008148 @default.
• W2016120446 hasConcept C55493867 @default.
• W2016120446 hasConcept C71924100 @default.
• W2016120446 hasConcept C86803240 @default.
• W2016120446 hasConcept C99454951 @default.
• W2016120446 hasConceptScore W2016120446C105702510 @default.
• W2016120446 hasConceptScore W2016120446C118303440 @default.
• W2016120446 hasConceptScore W2016120446C142724271 @default.
• W2016120446 hasConceptScore W2016120446C163170386 @default.
• W2016120446 hasConceptScore W2016120446C16930146 @default.
• W2016120446 hasConceptScore W2016120446C170493617 @default.
• W2016120446 hasConceptScore W2016120446C184297639 @default.
• W2016120446 hasConceptScore W2016120446C2776823239 @default.

• next