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• W2016771237 abstract "Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterised by amyloid plaques and neurofibrillary tangles within the brain. AD has a complex aetiology involving both genetic and environmental factors. Although several AD causative and susceptibility loci have been identified (APP, PSEN1, PSEN2, APOE), evidence from family and twin studies suggests there is a significant genetic component underlying AD which is not explained by these genes. To date a large number of studies have aimed to uncover the remaining disease-related loci. However, results have been inconsistent with a large number of novel loci implicated but few positive replications. The examination of genes, previously reported to be associated with AD, within independent AD genome-wide association studies (GWAS) has the potential to help identify genuine AD risk factors. We therefore analysed the current top candidate genes for AD within our large AD GWA dataset. Putative AD candidate genes were determined from two sources. Firstly, any genes reported as significantly associated in previous AD GWA studies were identified. In addition, the current top results from the AlzGgene database website (www.alzgene.org), which performs a constantly updated meta-analysis of all published AD genetic risk factors, were included. Candidate genes were examined in our GWA dataset which is comprised of 4,047 cases, 2,486 elderly controls and 6,377 population controls. All AD cases met criteria for either probable (NINCDS-AARDA, DSM-IV) or definite (CERAD) AD. Elderly controls were aged 60 years or over and were screened for cognitive decline or neuropathological signs of AD. Population controls were drawn from large existing cohorts with available GWAS data. 4572 individuals were genotyped at the Sanger Institute on the Illumina 610-quad chip. The remaining samples were genotyped using either the Illumina 317k or 550k whole-genome single-nucleotide polymorphism arrays. Results from the examination of the current top candidate genes for AD within our AD GWAS study will be presented at ICAD 2009. The results of this comparative study reinforce the necessity for replication and validation of other AD association studies, including GWAS, within large distinct datasets." @default.
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• W2016771237 date "2009-07-01" @default.
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• W2016771237 title "P4-124: An examination of previously reported Alzheimer candidate genes within a large genome-wide association dataset" @default.
• W2016771237 doi "https://doi.org/10.1016/j.jalz.2009.04.792" @default.
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