Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017344812> ?p ?o ?g. }
- W2017344812 endingPage "225" @default.
- W2017344812 startingPage "209" @default.
- W2017344812 abstract "Hypoxia is the major cause of necrotic cell death in myocardial infarction. Cellular energy supply and demand under hypoxic conditions is regulated by many interacting signaling and transcriptional networks, which complicates studies on individual proteins and pathways. We apply an integrated systems approach to understand the metabolic and functional response to hypoxia in muscle cells of the fruit fly Drosophila melanogaster. In addition to its utility as a hypoxia-tolerant model organism, Drosophila also offers advantages due to its small size, fecundity, and short life cycle. These traits, along with a large library of single-gene mutations, motivated us to develop new, computer-automated technology for gathering in vivo measurements of heart function under hypoxia for a large number of mutant strains. Phenotype data can be integrated with in silico cellular networks, metabolomic data, and microarrays to form qualitative and quantitative network models for prediction and hypothesis generation. Here we present a framework for a systems approach to hypoxia in the cardiac myocyte, starting from nuclear magnetic resonance (NMR) metabolomics, a constraint-based metabolic model, and phenotypic profiles." @default.
- W2017344812 created "2016-06-24" @default.
- W2017344812 creator A5004265401 @default.
- W2017344812 creator A5021668023 @default.
- W2017344812 creator A5033811596 @default.
- W2017344812 creator A5072649743 @default.
- W2017344812 date "2008-01-01" @default.
- W2017344812 modified "2023-10-14" @default.
- W2017344812 title "Integrating metabolomics and phenomics with systems models of cardiac hypoxia" @default.
- W2017344812 cites W107544894 @default.
- W2017344812 cites W1528001840 @default.
- W2017344812 cites W1553833389 @default.
- W2017344812 cites W1597403892 @default.
- W2017344812 cites W1597762351 @default.
- W2017344812 cites W1665428902 @default.
- W2017344812 cites W1797956629 @default.
- W2017344812 cites W1966726553 @default.
- W2017344812 cites W1966854042 @default.
- W2017344812 cites W1974482866 @default.
- W2017344812 cites W1980994248 @default.
- W2017344812 cites W1986174706 @default.
- W2017344812 cites W1993160376 @default.
- W2017344812 cites W1993417849 @default.
- W2017344812 cites W1996529795 @default.
- W2017344812 cites W1997265358 @default.
- W2017344812 cites W1997602632 @default.
- W2017344812 cites W2009810346 @default.
- W2017344812 cites W2009940763 @default.
- W2017344812 cites W2012852001 @default.
- W2017344812 cites W2023058301 @default.
- W2017344812 cites W2023883324 @default.
- W2017344812 cites W2025663053 @default.
- W2017344812 cites W2026089579 @default.
- W2017344812 cites W2030862040 @default.
- W2017344812 cites W2034273648 @default.
- W2017344812 cites W2035787551 @default.
- W2017344812 cites W2037614307 @default.
- W2017344812 cites W2041492515 @default.
- W2017344812 cites W2042880070 @default.
- W2017344812 cites W2046155446 @default.
- W2017344812 cites W2047876380 @default.
- W2017344812 cites W2048214825 @default.
- W2017344812 cites W2053751697 @default.
- W2017344812 cites W2056355049 @default.
- W2017344812 cites W2057817337 @default.
- W2017344812 cites W2060254175 @default.
- W2017344812 cites W2065163714 @default.
- W2017344812 cites W2065304353 @default.
- W2017344812 cites W2066060839 @default.
- W2017344812 cites W2066548975 @default.
- W2017344812 cites W2068065441 @default.
- W2017344812 cites W2069909471 @default.
- W2017344812 cites W2070951720 @default.
- W2017344812 cites W2073690515 @default.
- W2017344812 cites W2074027785 @default.
- W2017344812 cites W2074705578 @default.
- W2017344812 cites W2090802617 @default.
- W2017344812 cites W2090871922 @default.
- W2017344812 cites W2096245011 @default.
- W2017344812 cites W2096731539 @default.
- W2017344812 cites W2096767559 @default.
- W2017344812 cites W2099925531 @default.
- W2017344812 cites W2100270425 @default.
- W2017344812 cites W2104080300 @default.
- W2017344812 cites W2104108767 @default.
- W2017344812 cites W2104315543 @default.
- W2017344812 cites W2105581244 @default.
- W2017344812 cites W2106000284 @default.
- W2017344812 cites W2106421836 @default.
- W2017344812 cites W2107062718 @default.
- W2017344812 cites W2108512127 @default.
- W2017344812 cites W2108723074 @default.
- W2017344812 cites W2109759870 @default.
- W2017344812 cites W2112334970 @default.
- W2017344812 cites W2112811019 @default.
- W2017344812 cites W2113019448 @default.
- W2017344812 cites W2114390083 @default.
- W2017344812 cites W2114518254 @default.
- W2017344812 cites W2117486132 @default.
- W2017344812 cites W2117537408 @default.
- W2017344812 cites W2119279429 @default.
- W2017344812 cites W2126795450 @default.
- W2017344812 cites W2129439677 @default.
- W2017344812 cites W2132582966 @default.
- W2017344812 cites W2133132988 @default.
- W2017344812 cites W2133298156 @default.
- W2017344812 cites W2136273830 @default.
- W2017344812 cites W2137903195 @default.
- W2017344812 cites W2138520475 @default.
- W2017344812 cites W2139802966 @default.
- W2017344812 cites W2141340739 @default.
- W2017344812 cites W2141652419 @default.
- W2017344812 cites W2145665157 @default.
- W2017344812 cites W2146725851 @default.
- W2017344812 cites W2150908245 @default.
- W2017344812 cites W2151148996 @default.
- W2017344812 cites W2152336513 @default.
- W2017344812 cites W2156481615 @default.