Matches in SemOpenAlex for { <https://semopenalex.org/work/W2017367268> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2017367268 abstract "Two polypeptides (designated DTX-A and DTX-B) were purified from crude snake venom of Dendroaspis angusticeps using gel filtration, cation exchange column chromatography and cation exchange high performance liquid chromatography, and their blocking actions of K+ channels were investigated in rat brain synaptosomes. Both DTX-A and DTX-B inhibited the voltage-dependent 42K efflux from the synaptosomes. DTX-A blocked 42K efflux of both the rapidly inactivating phase (component T) and the slowly inactivating phase (component S). The inhibitory effect of DTX-A on component T was pronounced compared with that on component S. However, DTX-B selectively blocked 42K efflux of component S. The molecular weights of DTX-A and DTX-B were estimated to be ca 10,000 by SDS-polyacrylamide gel electrophoresis. The amino acid composition of these toxins is different from that of polypeptide purified from the venom of D. angusticeps (alpha-, beta-, gamma- and delta-DTX). These results suggest that DTX-A and DTX-B are new polypeptides which block voltage-dependent K+ channels selectively, and that they are useful tools for investigating the K+ channel." @default.
- W2017367268 created "2016-06-24" @default.
- W2017367268 creator A5010918922 @default.
- W2017367268 creator A5022043062 @default.
- W2017367268 creator A5039021133 @default.
- W2017367268 creator A5051509626 @default.
- W2017367268 date "1992-06-01" @default.
- W2017367268 modified "2023-10-14" @default.
- W2017367268 title "Purification and partial characterization of K+ channel blockers from the venom of Dendroaspis angusticeps" @default.
- W2017367268 cites W129611397 @default.
- W2017367268 cites W1482274624 @default.
- W2017367268 cites W1585316878 @default.
- W2017367268 cites W1775749144 @default.
- W2017367268 cites W1861640504 @default.
- W2017367268 cites W1972679916 @default.
- W2017367268 cites W1993865694 @default.
- W2017367268 cites W1995912428 @default.
- W2017367268 cites W1996196738 @default.
- W2017367268 cites W2024961442 @default.
- W2017367268 cites W2026659382 @default.
- W2017367268 cites W2026944918 @default.
- W2017367268 cites W2034129859 @default.
- W2017367268 cites W2043762161 @default.
- W2017367268 cites W2050575429 @default.
- W2017367268 cites W2051103116 @default.
- W2017367268 cites W2062385260 @default.
- W2017367268 cites W2062963816 @default.
- W2017367268 cites W2073068631 @default.
- W2017367268 cites W2073879684 @default.
- W2017367268 cites W2100837269 @default.
- W2017367268 cites W2159513541 @default.
- W2017367268 cites W2412587058 @default.
- W2017367268 cites W2461473392 @default.
- W2017367268 cites W39220136 @default.
- W2017367268 doi "https://doi.org/10.1016/0197-0186(92)90034-o" @default.
- W2017367268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1304870" @default.
- W2017367268 hasPublicationYear "1992" @default.
- W2017367268 type Work @default.
- W2017367268 sameAs 2017367268 @default.
- W2017367268 citedByCount "4" @default.
- W2017367268 countsByYear W20173672682014 @default.
- W2017367268 countsByYear W20173672682018 @default.
- W2017367268 crossrefType "journal-article" @default.
- W2017367268 hasAuthorship W2017367268A5010918922 @default.
- W2017367268 hasAuthorship W2017367268A5022043062 @default.
- W2017367268 hasAuthorship W2017367268A5039021133 @default.
- W2017367268 hasAuthorship W2017367268A5051509626 @default.
- W2017367268 hasConcept C116084860 @default.
- W2017367268 hasConcept C181199279 @default.
- W2017367268 hasConcept C185592680 @default.
- W2017367268 hasConcept C193363816 @default.
- W2017367268 hasConcept C200082930 @default.
- W2017367268 hasConcept C2779281246 @default.
- W2017367268 hasConcept C2779448229 @default.
- W2017367268 hasConcept C43617362 @default.
- W2017367268 hasConcept C55493867 @default.
- W2017367268 hasConcept C86803240 @default.
- W2017367268 hasConceptScore W2017367268C116084860 @default.
- W2017367268 hasConceptScore W2017367268C181199279 @default.
- W2017367268 hasConceptScore W2017367268C185592680 @default.
- W2017367268 hasConceptScore W2017367268C193363816 @default.
- W2017367268 hasConceptScore W2017367268C200082930 @default.
- W2017367268 hasConceptScore W2017367268C2779281246 @default.
- W2017367268 hasConceptScore W2017367268C2779448229 @default.
- W2017367268 hasConceptScore W2017367268C43617362 @default.
- W2017367268 hasConceptScore W2017367268C55493867 @default.
- W2017367268 hasConceptScore W2017367268C86803240 @default.
- W2017367268 hasLocation W20173672681 @default.
- W2017367268 hasLocation W20173672682 @default.
- W2017367268 hasOpenAccess W2017367268 @default.
- W2017367268 hasPrimaryLocation W20173672681 @default.
- W2017367268 hasRelatedWork W1987979243 @default.
- W2017367268 hasRelatedWork W1997080915 @default.
- W2017367268 hasRelatedWork W2000564470 @default.
- W2017367268 hasRelatedWork W2030781685 @default.
- W2017367268 hasRelatedWork W2054862544 @default.
- W2017367268 hasRelatedWork W2077110004 @default.
- W2017367268 hasRelatedWork W2331451391 @default.
- W2017367268 hasRelatedWork W2391264709 @default.
- W2017367268 hasRelatedWork W2427479962 @default.
- W2017367268 hasRelatedWork W3014377832 @default.
- W2017367268 isParatext "false" @default.
- W2017367268 isRetracted "false" @default.
- W2017367268 magId "2017367268" @default.
- W2017367268 workType "article" @default.