FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018088339> ?p ?o ?g. }

• W2018088339 endingPage "8568" @default.
• W2018088339 startingPage "8555" @default.
• W2018088339 abstract "Lipolysis is the biochemical pathway responsible for the catabolism of cellular triacylglycerol (TG). Lipolytic TG breakdown is a central metabolic process leading to the generation of free fatty acids (FA) and glycerol, thereby regulating lipid, as well as energy homeostasis. The precise tuning of lipolysis is imperative to prevent lipotoxicity, obesity, diabetes and other related metabolic disorders. Here, we present our finding that miR-124a attenuates RNA and protein expression of the major TG hydrolase, adipose triglyceride lipase (ATGL/PNPLA2) and its co-activator comparative gene identification 58 (CGI-58/ABHD5). Ectopic expression of miR-124a in adipocytes leads to reduced lipolysis and increased cellular TG accumulation. This phenotype, however, can be rescued by overexpression of truncated Atgl lacking its 3'UTR, which harbors the identified miR-124a target site. In addition, we observe a strong negative correlation between miR-124a and Atgl expression in various murine tissues. Moreover, miR-124a regulates the expression of Atgl and Cgi-58 in murine white adipose tissue during fasting as well as the expression of Atgl in murine liver, during fasting and re-feeding. Together, these results point to an instrumental role of miR-124a in the regulation of TG catabolism. Therefore, we suggest that miR-124a may be involved in the regulation of several cellular and organismal metabolic parameters, including lipid storage and plasma FA concentration." @default.
• W2018088339 created "2016-06-24" @default.
• W2018088339 creator A5006925208 @default.
• W2018088339 creator A5036664543 @default.
• W2018088339 creator A5044195535 @default.
• W2018088339 creator A5051973789 @default.
• W2018088339 creator A5052538915 @default.
• W2018088339 creator A5067511028 @default.
• W2018088339 creator A5073471101 @default.
• W2018088339 creator A5075328733 @default.
• W2018088339 creator A5081697719 @default.
• W2018088339 date "2015-04-16" @default.
• W2018088339 modified "2023-10-18" @default.
• W2018088339 title "Micro RNA-124a Regulates Lipolysis via Adipose Triglyceride Lipase and Comparative Gene Identification 58" @default.
• W2018088339 cites W1515226261 @default.
• W2018088339 cites W1966744895 @default.
• W2018088339 cites W1974134896 @default.
• W2018088339 cites W2006251119 @default.
• W2018088339 cites W2020950789 @default.
• W2018088339 cites W2029318573 @default.
• W2018088339 cites W2031858641 @default.
• W2018088339 cites W2037166744 @default.
• W2018088339 cites W2038874091 @default.
• W2018088339 cites W2059222949 @default.
• W2018088339 cites W2074872905 @default.
• W2018088339 cites W2077991483 @default.
• W2018088339 cites W2085407582 @default.
• W2018088339 cites W2088648948 @default.
• W2018088339 cites W2089762118 @default.
• W2018088339 cites W2090946848 @default.
• W2018088339 cites W2106442657 @default.
• W2018088339 cites W2121278592 @default.
• W2018088339 cites W2123864804 @default.
• W2018088339 cites W2128308857 @default.
• W2018088339 cites W2129744834 @default.
• W2018088339 cites W2131256997 @default.
• W2018088339 cites W2139175950 @default.
• W2018088339 cites W2144741116 @default.
• W2018088339 cites W2154085311 @default.
• W2018088339 cites W2156023352 @default.
• W2018088339 doi "https://doi.org/10.3390/ijms16048555" @default.
• W2018088339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4425096" @default.
• W2018088339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25894224" @default.
• W2018088339 hasPublicationYear "2015" @default.
• W2018088339 type Work @default.
• W2018088339 sameAs 2018088339 @default.
• W2018088339 citedByCount "24" @default.
• W2018088339 countsByYear W20180883392016 @default.
• W2018088339 countsByYear W20180883392017 @default.
• W2018088339 countsByYear W20180883392018 @default.
• W2018088339 countsByYear W20180883392019 @default.
• W2018088339 countsByYear W20180883392020 @default.
• W2018088339 countsByYear W20180883392021 @default.
• W2018088339 countsByYear W20180883392023 @default.
• W2018088339 crossrefType "journal-article" @default.
• W2018088339 hasAuthorship W2018088339A5006925208 @default.
• W2018088339 hasAuthorship W2018088339A5036664543 @default.
• W2018088339 hasAuthorship W2018088339A5044195535 @default.
• W2018088339 hasAuthorship W2018088339A5051973789 @default.
• W2018088339 hasAuthorship W2018088339A5052538915 @default.
• W2018088339 hasAuthorship W2018088339A5067511028 @default.
• W2018088339 hasAuthorship W2018088339A5073471101 @default.
• W2018088339 hasAuthorship W2018088339A5075328733 @default.
• W2018088339 hasAuthorship W2018088339A5081697719 @default.
• W2018088339 hasBestOaLocation W20180883391 @default.
• W2018088339 hasConcept C104317684 @default.
• W2018088339 hasConcept C126322002 @default.
• W2018088339 hasConcept C134018914 @default.
• W2018088339 hasConcept C140985366 @default.
• W2018088339 hasConcept C150194340 @default.
• W2018088339 hasConcept C151955695 @default.
• W2018088339 hasConcept C171089720 @default.
• W2018088339 hasConcept C181199279 @default.
• W2018088339 hasConcept C185592680 @default.
• W2018088339 hasConcept C25095133 @default.
• W2018088339 hasConcept C2777062983 @default.
• W2018088339 hasConcept C2778163477 @default.
• W2018088339 hasConcept C2778913445 @default.
• W2018088339 hasConcept C2779697368 @default.
• W2018088339 hasConcept C55493867 @default.
• W2018088339 hasConcept C71924100 @default.
• W2018088339 hasConcept C86803240 @default.
• W2018088339 hasConcept C95444343 @default.
• W2018088339 hasConcept C96942376 @default.
• W2018088339 hasConceptScore W2018088339C104317684 @default.
• W2018088339 hasConceptScore W2018088339C126322002 @default.
• W2018088339 hasConceptScore W2018088339C134018914 @default.
• W2018088339 hasConceptScore W2018088339C140985366 @default.
• W2018088339 hasConceptScore W2018088339C150194340 @default.
• W2018088339 hasConceptScore W2018088339C151955695 @default.
• W2018088339 hasConceptScore W2018088339C171089720 @default.
• W2018088339 hasConceptScore W2018088339C181199279 @default.
• W2018088339 hasConceptScore W2018088339C185592680 @default.
• W2018088339 hasConceptScore W2018088339C25095133 @default.
• W2018088339 hasConceptScore W2018088339C2777062983 @default.
• W2018088339 hasConceptScore W2018088339C2778163477 @default.
• W2018088339 hasConceptScore W2018088339C2778913445 @default.
• W2018088339 hasConceptScore W2018088339C2779697368 @default.

• next