Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018737156> ?p ?o ?g. }
- W2018737156 endingPage "165" @default.
- W2018737156 startingPage "159" @default.
- W2018737156 abstract "Matrix metalloproteases from the cell surface cleave an 80 kDa E-cadherin fragment (sE-CAD) that induces invasion of cancer cells into collagen type I and inhibits cellular aggregation. Conditioned media from MDCKts.srcCl2 cells at 40 degrees C and 35 degrees C, PCm.src5 and COLO-16 cells at 37 degrees C contained spontaneously released sE-CAD; these 48 h old conditioned media were capable of inhibiting E-cadherin functions in a paracrine way. Here we show direct cleavage of the extracellular domain of E-cadherin by the serine protease plasmin. sE-CAD released by plasmin inhibits E-cadherin functions as evidenced by induction of invasion into collagen type I and inhibition of cellular aggregation. This functional inhibition by sE-CAD was reversed by aprotinin or by immunoadsorption on protein Sepharose 4 fast flow beads with antibodies against the extracellular part of E-cadherin. Our results demonstrate that plasmin produces extracellular E-cadherin fragments which regulate E-cadherin function in cells containing an intact E-cadherin/catenin complex." @default.
- W2018737156 created "2016-06-24" @default.
- W2018737156 creator A5006704966 @default.
- W2018737156 creator A5033749421 @default.
- W2018737156 creator A5035594458 @default.
- W2018737156 creator A5049291299 @default.
- W2018737156 creator A5063220291 @default.
- W2018737156 creator A5065445325 @default.
- W2018737156 creator A5070209429 @default.
- W2018737156 creator A5086784694 @default.
- W2018737156 creator A5089838749 @default.
- W2018737156 date "2002-01-23" @default.
- W2018737156 modified "2023-10-12" @default.
- W2018737156 title "Plasmin Produces an E-Cadherin Fragment That Stimulates Cancer Cell Invasion" @default.
- W2018737156 cites W1919303367 @default.
- W2018737156 cites W1964223904 @default.
- W2018737156 cites W1964520279 @default.
- W2018737156 cites W1971219606 @default.
- W2018737156 cites W1976831807 @default.
- W2018737156 cites W1997341361 @default.
- W2018737156 cites W2000008804 @default.
- W2018737156 cites W2005088732 @default.
- W2018737156 cites W2005113904 @default.
- W2018737156 cites W2018954341 @default.
- W2018737156 cites W2021943477 @default.
- W2018737156 cites W2027586189 @default.
- W2018737156 cites W2032345748 @default.
- W2018737156 cites W2035331118 @default.
- W2018737156 cites W2041123249 @default.
- W2018737156 cites W2050640960 @default.
- W2018737156 cites W2053758478 @default.
- W2018737156 cites W2055298771 @default.
- W2018737156 cites W2066471576 @default.
- W2018737156 cites W2068955281 @default.
- W2018737156 cites W2069951758 @default.
- W2018737156 cites W2071704383 @default.
- W2018737156 cites W2085224921 @default.
- W2018737156 cites W2086347831 @default.
- W2018737156 cites W2094885378 @default.
- W2018737156 cites W2107746069 @default.
- W2018737156 cites W2116615268 @default.
- W2018737156 cites W2124499018 @default.
- W2018737156 cites W2161968975 @default.
- W2018737156 cites W2171284757 @default.
- W2018737156 cites W2200590058 @default.
- W2018737156 cites W2323332869 @default.
- W2018737156 cites W2329979908 @default.
- W2018737156 cites W2396086641 @default.
- W2018737156 doi "https://doi.org/10.1515/bc.2002.016" @default.
- W2018737156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11928810" @default.
- W2018737156 hasPublicationYear "2002" @default.
- W2018737156 type Work @default.
- W2018737156 sameAs 2018737156 @default.
- W2018737156 citedByCount "79" @default.
- W2018737156 countsByYear W20187371562012 @default.
- W2018737156 countsByYear W20187371562013 @default.
- W2018737156 countsByYear W20187371562014 @default.
- W2018737156 countsByYear W20187371562015 @default.
- W2018737156 countsByYear W20187371562016 @default.
- W2018737156 countsByYear W20187371562017 @default.
- W2018737156 countsByYear W20187371562019 @default.
- W2018737156 countsByYear W20187371562020 @default.
- W2018737156 countsByYear W20187371562021 @default.
- W2018737156 countsByYear W20187371562023 @default.
- W2018737156 crossrefType "journal-article" @default.
- W2018737156 hasAuthorship W2018737156A5006704966 @default.
- W2018737156 hasAuthorship W2018737156A5033749421 @default.
- W2018737156 hasAuthorship W2018737156A5035594458 @default.
- W2018737156 hasAuthorship W2018737156A5049291299 @default.
- W2018737156 hasAuthorship W2018737156A5063220291 @default.
- W2018737156 hasAuthorship W2018737156A5065445325 @default.
- W2018737156 hasAuthorship W2018737156A5070209429 @default.
- W2018737156 hasAuthorship W2018737156A5086784694 @default.
- W2018737156 hasAuthorship W2018737156A5089838749 @default.
- W2018737156 hasConcept C121608353 @default.
- W2018737156 hasConcept C141071460 @default.
- W2018737156 hasConcept C1491633281 @default.
- W2018737156 hasConcept C149402561 @default.
- W2018737156 hasConcept C153911025 @default.
- W2018737156 hasConcept C181199279 @default.
- W2018737156 hasConcept C185592680 @default.
- W2018737156 hasConcept C189165786 @default.
- W2018737156 hasConcept C2776714187 @default.
- W2018737156 hasConcept C2777807008 @default.
- W2018737156 hasConcept C2780799893 @default.
- W2018737156 hasConcept C2781071845 @default.
- W2018737156 hasConcept C28406088 @default.
- W2018737156 hasConcept C54355233 @default.
- W2018737156 hasConcept C55493867 @default.
- W2018737156 hasConcept C71924100 @default.
- W2018737156 hasConcept C86803240 @default.
- W2018737156 hasConcept C95444343 @default.
- W2018737156 hasConcept C96232424 @default.
- W2018737156 hasConceptScore W2018737156C121608353 @default.
- W2018737156 hasConceptScore W2018737156C141071460 @default.
- W2018737156 hasConceptScore W2018737156C1491633281 @default.
- W2018737156 hasConceptScore W2018737156C149402561 @default.
- W2018737156 hasConceptScore W2018737156C153911025 @default.