Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018907079> ?p ?o ?g. }
- W2018907079 endingPage "109" @default.
- W2018907079 startingPage "97" @default.
- W2018907079 abstract "Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies implicated several genes as PD risk loci with strong, but not genome-wide significant, associations. In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in SNCA (rs2736990, p-value = 6.7 × 10−8; genome-wide adjusted p = 0.0109, odds ratio (OR) = 1.29 [95% CI: 1.17–1.42] G vs. A allele, population attributable risk percent (PAR%) = 12%) and the MAPT region (rs11012, p-value = 5.6 × 10−8; genome-wide adjusted p = 0.0079, OR = 0.70 [95% CI: 0.62–0.79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD." @default.
- W2018907079 created "2016-06-24" @default.
- W2018907079 creator A5004289607 @default.
- W2018907079 creator A5013186296 @default.
- W2018907079 creator A5020266650 @default.
- W2018907079 creator A5020855307 @default.
- W2018907079 creator A5027745248 @default.
- W2018907079 creator A5031669486 @default.
- W2018907079 creator A5039084500 @default.
- W2018907079 creator A5039717261 @default.
- W2018907079 creator A5051577475 @default.
- W2018907079 creator A5055332509 @default.
- W2018907079 creator A5057364983 @default.
- W2018907079 creator A5059076747 @default.
- W2018907079 creator A5063493384 @default.
- W2018907079 creator A5063659153 @default.
- W2018907079 creator A5069324665 @default.
- W2018907079 creator A5076875985 @default.
- W2018907079 creator A5083429290 @default.
- W2018907079 creator A5088238884 @default.
- W2018907079 date "2010-03-01" @default.
- W2018907079 modified "2023-10-15" @default.
- W2018907079 title "Genome-Wide Association Study Confirms SNPs in<i>SNCA</i>and the<i>MAPT</i>Region as Common Risk Factors for Parkinson Disease" @default.
- W2018907079 cites W119618776 @default.
- W2018907079 cites W1502551601 @default.
- W2018907079 cites W150987474 @default.
- W2018907079 cites W1527671059 @default.
- W2018907079 cites W1614256764 @default.
- W2018907079 cites W1847168837 @default.
- W2018907079 cites W1877873625 @default.
- W2018907079 cites W1965778124 @default.
- W2018907079 cites W1966217137 @default.
- W2018907079 cites W1966533302 @default.
- W2018907079 cites W1969426970 @default.
- W2018907079 cites W1979659124 @default.
- W2018907079 cites W1983643492 @default.
- W2018907079 cites W1990984249 @default.
- W2018907079 cites W1991175708 @default.
- W2018907079 cites W1991492245 @default.
- W2018907079 cites W1996129941 @default.
- W2018907079 cites W1997709333 @default.
- W2018907079 cites W1998342470 @default.
- W2018907079 cites W2001283231 @default.
- W2018907079 cites W2002137163 @default.
- W2018907079 cites W2003484643 @default.
- W2018907079 cites W2010612415 @default.
- W2018907079 cites W2018756041 @default.
- W2018907079 cites W2034378072 @default.
- W2018907079 cites W2035151000 @default.
- W2018907079 cites W2038793661 @default.
- W2018907079 cites W2039294533 @default.
- W2018907079 cites W2041664288 @default.
- W2018907079 cites W2042103448 @default.
- W2018907079 cites W2046015265 @default.
- W2018907079 cites W2046177676 @default.
- W2018907079 cites W2052349084 @default.
- W2018907079 cites W2053652338 @default.
- W2018907079 cites W2054873349 @default.
- W2018907079 cites W2056127416 @default.
- W2018907079 cites W2056241036 @default.
- W2018907079 cites W2062171503 @default.
- W2018907079 cites W2062360332 @default.
- W2018907079 cites W2063127941 @default.
- W2018907079 cites W2063787422 @default.
- W2018907079 cites W2064233040 @default.
- W2018907079 cites W2070235707 @default.
- W2018907079 cites W2072978870 @default.
- W2018907079 cites W2073893553 @default.
- W2018907079 cites W2074608247 @default.
- W2018907079 cites W2076651708 @default.
- W2018907079 cites W2077723521 @default.
- W2018907079 cites W2080368522 @default.
- W2018907079 cites W2083767901 @default.
- W2018907079 cites W2086787068 @default.
- W2018907079 cites W2088865635 @default.
- W2018907079 cites W2091265794 @default.
- W2018907079 cites W2092431803 @default.
- W2018907079 cites W2094826609 @default.
- W2018907079 cites W2095499628 @default.
- W2018907079 cites W2098126593 @default.
- W2018907079 cites W2098187463 @default.
- W2018907079 cites W2100300726 @default.
- W2018907079 cites W2104382960 @default.
- W2018907079 cites W2118544659 @default.
- W2018907079 cites W2120599753 @default.
- W2018907079 cites W2121308112 @default.
- W2018907079 cites W2123431154 @default.
- W2018907079 cites W2123944789 @default.
- W2018907079 cites W2130348423 @default.
- W2018907079 cites W2132445034 @default.
- W2018907079 cites W2136637949 @default.
- W2018907079 cites W2138834360 @default.
- W2018907079 cites W2139084760 @default.
- W2018907079 cites W2139233019 @default.
- W2018907079 cites W2139647754 @default.
- W2018907079 cites W2142068079 @default.
- W2018907079 cites W2142120135 @default.
- W2018907079 cites W2142286857 @default.