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• W2019771610 endingPage "517" @default.
• W2019771610 startingPage "505" @default.
• W2019771610 abstract "Abstract Background: Alterations in retinal amino acid neurochemistry are an indicator of metabolic function. Glutamate is the primary excitatory amino acid neurotransmitter within the retina, and excessive levels of glutamate can potentially cause excitotoxicity, in particular, through the N‐methyl‐D‐aspartate (NMDA) subtype of glutamate receptor. Anomalies in NMDA receptor function have been implicated as causing many neurodegenerative disorders, and overactivation leads to neuronal death secondary to metabolic insult. Several pharmaceutical agents have been proposed as potential neuroprotective agents against excitotoxicity (e.g. betaxolol), yet any effects such drugs have on retinal neurochemistry have not been determined. Therefore, the aim of this study was to quantify the changes in retinal amino acid neurochemistry secondary to the application of NMDA with and without betaxolol. Methods: Functional NMDA channel activation was confirmed in both amacrine and ganglion cells by quantifying the entry into these neurones of a channel permeable probe (agmatine: 1‐amino‐4‐guanidobutane [AGB]). By probing serial thin sections with immunoglobulins targeting AGB, glutamate, γ‐aminobutyric acid (GABA) and glycine, it was possible to simultaneously study the neurochemical characteristic as well as the NMDA‐evoked AGB responses of different neurochemical populations of inner retinal neurones. Results: The authors have previously shown no accumulation of glutamate or GABA within Müller cells following NMDA application. Herein they report altered GABA and glycine immunoreactivity, but not glutamate immunoreactivity within neurones of the amacrine and ganglion cell layers following NMDA application. Finally, the addition of betaxolol did not significantly alter the normal neurochemistry of the retina. Conclusion: The retina possesses intrinsic mechanisms that allow it to maintain metabolic integrity during short periods of high NMDA application." @default.
• W2019771610 created "2016-06-24" @default.
• W2019771610 creator A5008375114 @default.
• W2019771610 creator A5060233023 @default.
• W2019771610 date "2004-10-01" @default.
• W2019771610 modified "2023-10-15" @default.
• W2019771610 title "Quantification of amino acid neurochemistry secondary to NMDA or betaxolol application" @default.
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• W2019771610 doi "https://doi.org/10.1111/j.1442-9071.2004.00885.x" @default.
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