Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020938078> ?p ?o ?g. }
- W2020938078 endingPage "622" @default.
- W2020938078 startingPage "615" @default.
- W2020938078 abstract "Purpose of review The focus of this review is on current research involving long-term calorie restriction and the resulting changes observed in possible biomarkers of aging. Special emphasis will be given to the basic and clinical science studies which are currently investigating the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age and obesity in humans. Recent findings Prolonged calorie restriction has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats, and mice. Mechanisms of this lifespan extension via calorie restriction are not fully elucidated, but possibly involve significant alterations in energy metabolism, oxidative damage, insulin sensitivity, and functional changes in both the neuroendocrine and sympathetic nervous systems. Ongoing studies of prolonged energy restriction in humans are now making it possible to analyze changes in these aging biomarkers to unravel some of the mechanisms of its antiaging phenomenon. Summary With the incremental expansion of research endeavors in the area of energy or calorie restriction, data on the effects of calorie restriction in animal models and humans are becoming more accessible. Detailed analyses from controlled human trials involving long-term calorie restriction will allow investigators to link observed alterations in body composition down to changes in molecular pathways and gene expression, with their possible effects on the biomarkers of aging." @default.
- W2020938078 created "2016-06-24" @default.
- W2020938078 creator A5027639502 @default.
- W2020938078 creator A5036557857 @default.
- W2020938078 creator A5069618649 @default.
- W2020938078 date "2004-11-01" @default.
- W2020938078 modified "2023-09-27" @default.
- W2020938078 title "Energy restriction and aging" @default.
- W2020938078 cites W133780831 @default.
- W2020938078 cites W141343633 @default.
- W2020938078 cites W1488124756 @default.
- W2020938078 cites W1583148430 @default.
- W2020938078 cites W1590732591 @default.
- W2020938078 cites W1754174631 @default.
- W2020938078 cites W1796065055 @default.
- W2020938078 cites W1828498691 @default.
- W2020938078 cites W1832860099 @default.
- W2020938078 cites W1933788686 @default.
- W2020938078 cites W1963828400 @default.
- W2020938078 cites W1966817531 @default.
- W2020938078 cites W1968792362 @default.
- W2020938078 cites W1969408132 @default.
- W2020938078 cites W1969915992 @default.
- W2020938078 cites W1975439264 @default.
- W2020938078 cites W1982647833 @default.
- W2020938078 cites W1985425785 @default.
- W2020938078 cites W1987738803 @default.
- W2020938078 cites W1989242095 @default.
- W2020938078 cites W1992247952 @default.
- W2020938078 cites W2002097809 @default.
- W2020938078 cites W2017356757 @default.
- W2020938078 cites W2021493008 @default.
- W2020938078 cites W2025028134 @default.
- W2020938078 cites W2027423883 @default.
- W2020938078 cites W2028510530 @default.
- W2020938078 cites W2029853631 @default.
- W2020938078 cites W2030134419 @default.
- W2020938078 cites W2030679612 @default.
- W2020938078 cites W2033206335 @default.
- W2020938078 cites W2037328323 @default.
- W2020938078 cites W2044399577 @default.
- W2020938078 cites W2053631715 @default.
- W2020938078 cites W2060814375 @default.
- W2020938078 cites W2061286916 @default.
- W2020938078 cites W2061597050 @default.
- W2020938078 cites W2064310817 @default.
- W2020938078 cites W2066660409 @default.
- W2020938078 cites W2071314267 @default.
- W2020938078 cites W2073151196 @default.
- W2020938078 cites W2073701988 @default.
- W2020938078 cites W2074740541 @default.
- W2020938078 cites W2074930831 @default.
- W2020938078 cites W2077102648 @default.
- W2020938078 cites W2077180087 @default.
- W2020938078 cites W2078993527 @default.
- W2020938078 cites W2087300435 @default.
- W2020938078 cites W2091087465 @default.
- W2020938078 cites W2097410945 @default.
- W2020938078 cites W2099669528 @default.
- W2020938078 cites W2104009496 @default.
- W2020938078 cites W2108428313 @default.
- W2020938078 cites W2126512104 @default.
- W2020938078 cites W2126644867 @default.
- W2020938078 cites W2127594986 @default.
- W2020938078 cites W2134775482 @default.
- W2020938078 cites W2143118003 @default.
- W2020938078 cites W2143730031 @default.
- W2020938078 cites W2145077123 @default.
- W2020938078 cites W2146081185 @default.
- W2020938078 cites W2150348010 @default.
- W2020938078 cites W2152340053 @default.
- W2020938078 cites W2152407864 @default.
- W2020938078 cites W2155473438 @default.
- W2020938078 cites W2155718945 @default.
- W2020938078 cites W2157271021 @default.
- W2020938078 cites W2158650639 @default.
- W2020938078 cites W2158822657 @default.
- W2020938078 cites W2162595307 @default.
- W2020938078 cites W2163805110 @default.
- W2020938078 cites W2167981278 @default.
- W2020938078 cites W2168072469 @default.
- W2020938078 cites W2170344274 @default.
- W2020938078 cites W2171005455 @default.
- W2020938078 cites W2171391341 @default.
- W2020938078 cites W2252987526 @default.
- W2020938078 cites W2916596946 @default.
- W2020938078 cites W4230854484 @default.
- W2020938078 cites W4233675981 @default.
- W2020938078 cites W4234984997 @default.
- W2020938078 cites W4241515291 @default.
- W2020938078 cites W4246034841 @default.
- W2020938078 cites W4251126650 @default.
- W2020938078 cites W4253972133 @default.
- W2020938078 doi "https://doi.org/10.1097/00075197-200411000-00005" @default.
- W2020938078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15534428" @default.
- W2020938078 hasPublicationYear "2004" @default.
- W2020938078 type Work @default.
- W2020938078 sameAs 2020938078 @default.