Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022368254> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2022368254 endingPage "290" @default.
- W2022368254 startingPage "287" @default.
- W2022368254 abstract "Thrombocytopenia is a common condition in the critical care setting. Repetitive platelet transfusion might lead to formation of alloantibodies. HLA class I and human platelet antigen antibodies can lead to transfusion-refractory thrombocytopenia. Transfusion of cross-matched platelets often is effective in these patients. We report on the successful use of recombinant activated factor VII in an acute bleeding situation in a multi-transfused patient presenting with positive HLA class I alloantibody status and thrombocytopenia associated with platelet dysfunction refractory to even transfusion of cross-matched platelets. The 41-year-old female patient developed HLA class I antibodies during former episodes of massive transfusion. Her former medical history was empty concerning hemorrhagic events. During this specific bleeding episode the patient suffered from intractable profuse bleeding from the nasopharynx and oral cavity. Global coagulation tests were within the normal range. Platelet dysfunction was confirmed by PFA100. Initially the patient responded well to Desmopressin infusion, but after 36 h she became thrombocytopenic and refractory to even transfusion of cross-matched platelets. Recombinant activated factor VII was chosen as the last resort. Two identical boli of 160 microg/kg NovoSeven each were injected via a central line within an interval of 3 h. After the first injection bleeding was significantly reduced and vasopressor support discontinued. After the second bolus bleeding completely ceased and did not reoccur. We did not observe any side effects. The pluripotent hemostatic agent recombinant activated factor VII might be a new option in the treatment of hemorrhagic episodes in patients presenting with this rare disorder, especially when the patient is refractory to cross-matched platelets or matched platelets are not available." @default.
- W2022368254 created "2016-06-24" @default.
- W2022368254 creator A5055219457 @default.
- W2022368254 creator A5055513535 @default.
- W2022368254 date "2005-06-01" @default.
- W2022368254 modified "2023-10-16" @default.
- W2022368254 title "Management of bleeding in a multi-transfused patient with positive HLA class I alloantibodies and thrombocytopenia associated with platelet dysfunction refractory to transfusion of cross-matched platelets" @default.
- W2022368254 cites W1996136719 @default.
- W2022368254 cites W2024106944 @default.
- W2022368254 cites W2046936517 @default.
- W2022368254 cites W2091630254 @default.
- W2022368254 cites W300722766 @default.
- W2022368254 cites W4245433948 @default.
- W2022368254 doi "https://doi.org/10.1097/01.mbc.0000169222.46420.cf" @default.
- W2022368254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15870549" @default.
- W2022368254 hasPublicationYear "2005" @default.
- W2022368254 type Work @default.
- W2022368254 sameAs 2022368254 @default.
- W2022368254 citedByCount "29" @default.
- W2022368254 countsByYear W20223682542012 @default.
- W2022368254 countsByYear W20223682542013 @default.
- W2022368254 countsByYear W20223682542015 @default.
- W2022368254 countsByYear W20223682542016 @default.
- W2022368254 countsByYear W20223682542017 @default.
- W2022368254 countsByYear W20223682542020 @default.
- W2022368254 countsByYear W20223682542021 @default.
- W2022368254 countsByYear W20223682542022 @default.
- W2022368254 crossrefType "journal-article" @default.
- W2022368254 hasAuthorship W2022368254A5055219457 @default.
- W2022368254 hasAuthorship W2022368254A5055513535 @default.
- W2022368254 hasConcept C121332964 @default.
- W2022368254 hasConcept C126322002 @default.
- W2022368254 hasConcept C141071460 @default.
- W2022368254 hasConcept C142424586 @default.
- W2022368254 hasConcept C147483822 @default.
- W2022368254 hasConcept C188280979 @default.
- W2022368254 hasConcept C203014093 @default.
- W2022368254 hasConcept C2776689292 @default.
- W2022368254 hasConcept C2778961111 @default.
- W2022368254 hasConcept C2779936836 @default.
- W2022368254 hasConcept C71924100 @default.
- W2022368254 hasConcept C87355193 @default.
- W2022368254 hasConcept C89560881 @default.
- W2022368254 hasConcept C90924648 @default.
- W2022368254 hasConceptScore W2022368254C121332964 @default.
- W2022368254 hasConceptScore W2022368254C126322002 @default.
- W2022368254 hasConceptScore W2022368254C141071460 @default.
- W2022368254 hasConceptScore W2022368254C142424586 @default.
- W2022368254 hasConceptScore W2022368254C147483822 @default.
- W2022368254 hasConceptScore W2022368254C188280979 @default.
- W2022368254 hasConceptScore W2022368254C203014093 @default.
- W2022368254 hasConceptScore W2022368254C2776689292 @default.
- W2022368254 hasConceptScore W2022368254C2778961111 @default.
- W2022368254 hasConceptScore W2022368254C2779936836 @default.
- W2022368254 hasConceptScore W2022368254C71924100 @default.
- W2022368254 hasConceptScore W2022368254C87355193 @default.
- W2022368254 hasConceptScore W2022368254C89560881 @default.
- W2022368254 hasConceptScore W2022368254C90924648 @default.
- W2022368254 hasIssue "4" @default.
- W2022368254 hasLocation W20223682541 @default.
- W2022368254 hasLocation W20223682542 @default.
- W2022368254 hasOpenAccess W2022368254 @default.
- W2022368254 hasPrimaryLocation W20223682541 @default.
- W2022368254 hasRelatedWork W2028540025 @default.
- W2022368254 hasRelatedWork W2035760964 @default.
- W2022368254 hasRelatedWork W2053350211 @default.
- W2022368254 hasRelatedWork W2104835969 @default.
- W2022368254 hasRelatedWork W2117503250 @default.
- W2022368254 hasRelatedWork W2152758372 @default.
- W2022368254 hasRelatedWork W2952789016 @default.
- W2022368254 hasRelatedWork W295478337 @default.
- W2022368254 hasRelatedWork W4243538971 @default.
- W2022368254 hasRelatedWork W4255553934 @default.
- W2022368254 hasVolume "16" @default.
- W2022368254 isParatext "false" @default.
- W2022368254 isRetracted "false" @default.
- W2022368254 magId "2022368254" @default.
- W2022368254 workType "article" @default.