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- W2022602407 endingPage "310" @default.
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- W2022602407 abstract "Conrad Waddington published an influential model for evolution in his 1942 paper, Canalization of Development and Inheritance of Acquired Characters. In this classic, albeit controversial, paper, he proposed that an unknown mechanism exists that conceals phenotypic variation until the organism is stressed. Recent studies have proposed that the highly conserved chaperone Hsp90 could function as a “capacitor,” or an “adaptively inducible canalizer,” that masks silent phenotypic variation of either genetic or epigenetic origin. This review will discuss evidence for, and arguments against, the role of Hsp90 as a capacitor for morphological evolution, and as a key component of what we call “Waddington’s widget.”" @default.
- W2022602407 created "2016-06-24" @default.
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- W2022602407 date "2003-10-01" @default.
- W2022602407 modified "2023-09-30" @default.
- W2022602407 title "Waddington’s widget: Hsp90 and the inheritance of acquired characters" @default.
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- W2022602407 doi "https://doi.org/10.1016/j.semcdb.2003.09.024" @default.
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