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- W2023334038 abstract "It has been shown that T8+ cells are comprised of functionally heterogeneous subpopulations such as suppressor, cytotoxic, and NK cells. In this report, we attempted to delineate the functional heterogeneity of T8 cells defined by anti-CD11 antibody (anti-Mol). Although allospecific cytotoxic activity was restricted to the T8+Mol− subset, suppression of PWM IgG synthesis could be elicited in both the T8+Mol+ and the T8+Mol− subset of cells. However, the mechanism of suppression was different in these two subsets. Suppression by the T8+Mol− subset of cells required the interaction with the T4+2H4+ suppressor inducer cells, whereas the T8+Mol+ subset of cells could suppress in the absence of the suppressor inducer cells. Moreover, recombinant interleukin-2 alone could augment this suppression by the T8+Mol+ subset, but did not induce suppression by the T8+Mol− subset. In contrast, NK and LAK activity was exclusively found in the T8+Mol+ subset of cells but not in the T8+Mol− subset of cells. These results suggest that the CD11 molecule is useful for distinguishing novel subsets of T8 cells." @default.
- W2023334038 created "2016-06-24" @default.
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- W2023334038 date "1988-02-01" @default.
- W2023334038 modified "2023-09-30" @default.
- W2023334038 title "CD11 molecule defines two types of suppressor cells within the T8+ population" @default.
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- W2023334038 doi "https://doi.org/10.1016/0008-8749(88)90103-7" @default.
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